Speckle-Type POZ Protein (SPOP) ELISA Kits

SPOP encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. Zusätzlich bieten wir Ihnen Speckle-Type POZ Protein Antikörper (58) und Speckle-Type POZ Protein Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

list all ELISA KIts Gen GeneID UniProt
SPOP 8405 O43791
SPOP 20747 Q6ZWS8
SPOP 287643  
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Top Speckle-Type POZ Protein ELISA Kits auf antikoerper-online.de

Showing 10 out of 20 products:

Katalog Nr. Reaktivität Sensitivität Bereich Bilder Menge Anbieter Lieferzeit Preis Details
Maus 0.094 ng/mL 0.156-10 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$638.00
Details
Human 0.469 ng/mL 0.781-50 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$638.00
Details
Schwein 0.469 ng/mL 0.781-50 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Meerschweinchen 0.094 ng/mL 0.156-10 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Huhn 0.469 ng/mL 0.781-50 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Kaninchen 0.375 ng/mL 0.625-40 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Affe 0.469 ng/mL 0.781-50 ng/mL   96 Tests Anmelden zum Anzeigen 12 bis 14 Tage
$715.00
Details
Ratte
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Hund
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$707.14
Details
Rind (Kuh)
  96 Tests Anmelden zum Anzeigen 15 bis 18 Tage
$1,029.60
Details

Weitere ELISA Kits für Speckle-Type POZ Protein Interaktionspartner

Xenopus laevis Speckle-Type POZ Protein (SPOP) Interaktionspartner

  1. Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (zeige GLI1 ELISA Kits)/Ci proteins in the Hh pathway.

Human Speckle-Type POZ Protein (SPOP) Interaktionspartner

  1. methylation status of SPOP promoter can be used as a novel epigenetic biomarker and a therapeutic target in colorectal cancer.

  2. these data highlight SPOP as an important regulator of luminal epithelial cell proliferation and c-MYC (zeige MYC ELISA Kits) expression in prostate physiology, identify c-MYC (zeige MYC ELISA Kits) as a novel bona fide SPOP substrate, and help explain the frequent inactivation of SPOP in human prostate adenocarcinoma.

  3. Results elucidate the tumor-suppressor role of SPOP in prostate cancer in which it acts as a negative regulator of BET protein stability and also provide a molecular mechanism for resistance to BET inhibitors in individuals with prostate cancer bearing SPOP mutations.

  4. SPOP mutation in endometrial cancer increased degradation of BRD2 (zeige BRD2 ELISA Kits), BRD3 (zeige BRD3 ELISA Kits) and BRD4 (zeige BRD4 ELISA Kits) proteins. SPOP mutation in prostate cancer increased expression of BRD2 (zeige BRD2 ELISA Kits), BRD3 (zeige BRD3 ELISA Kits) and BRD4 (zeige BRD4 ELISA Kits) proteins.

  5. Prostate cancer-derived SPOP mutants failed to interact with Cdc20 (zeige CDC20 ELISA Kits) to promote its degradation. As a result, SPOP-deficient prostate cancer cells with elevated Cdc20 (zeige CDC20 ELISA Kits) expression became resistant to a pharmacological Cdc20 (zeige CDC20 ELISA Kits) inhibitor.

  6. While wild-type SPOP localizes to liquid nuclear speckles, self-association-deficient SPOP mutants have a diffuse distribution in the nucleus. SPOP oligomerizes through its BTB and BACK domains.

  7. SPOP mutation activates both PI3K (zeige PIK3CA ELISA Kits)/mTOR (zeige FRAP1 ELISA Kits) and androgen receptor (zeige AR ELISA Kits) signaling, effectively uncoupling the normal negative feedback between these two pathways.

  8. SPOP-containing complex regulates SETD2 stability and H3K36me3-coupled alternative splicing.

  9. The levels of SPOP significantly decreased, while the levels of SIRT2 (zeige SIRT2 ELISA Kits) significantly increased in non-small cell lung cancer (NSCLC) cell lines, compared to normal bronchial epithelial cell line and NSCLC specimens, compared to the paired non-tumor lung tissue.

  10. hese findings reveal novel molecular events underlying the regulation of INF2 (zeige INF2 ELISA Kits) function and localization, and provided insights in understanding the relationship between SPOP mutations and dysregulation of mitochondrial dynamics in prostate cancer.

Mouse (Murine) Speckle-Type POZ Protein (SPOP) Interaktionspartner

  1. Results demonstrate a negative role of Spop in the level and activity of Gli3 (zeige GLI3 ELISA Kits), Shh (zeige SHH ELISA Kits) signaling and ventral spinal cord patterning.

  2. Speckle-type pox virus and zinc finger (POZ) protein (SPOP) regulates endometrial stromal cell decidualization in mice and that hormones regulate the expression of SPOP. This study suggests that ubiquitination may be involved in embryonic implantation.

  3. These results implicate SPOP as a novel participant in DNA double strand break repair and suggest that SPOP mutation drives prostate tumorigenesis in part through genomic instability.

  4. miR (zeige MLXIP ELISA Kits)-145 has a role in post-transcriptional regulation of SPOP expression in selected tissues.

  5. Dzip1-dependent stabilization of Spop/HIB is evolutionarily conserved and essential for proper regulation of Gli (zeige GLI1 ELISA Kits)/Ci proteins in the Hh pathway.

  6. similar S/T-rich motifs are present in Gli (zeige GLI1 ELISA Kits) proteins as well as in numerous HIB-interacting proteins and mediate Gli (zeige GLI1 ELISA Kits) degradation by SPOP

  7. MacroH2A1.2 (zeige H2AFY ELISA Kits) binds the nuclear protein (zeige HEMGN ELISA Kits) Spop.

  8. Interaction of endogenous PDX-1 (zeige PDX1 ELISA Kits) and PCIF1 in MIN6 insulinoma (zeige RPS15 ELISA Kits) cells, is demonstarted.

Speckle-Type POZ Protein (SPOP) Antigen-Profil

Beschreibung des Gens

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.

Genbezeichner und Symbole assoziert mit SPOP

  • speckle type POZ protein (spop) Antikörper
  • speckle type BTB/POZ protein (SPOP) Antikörper
  • Speckle-type POZ protein (Bm1_45730) Antikörper
  • speckle-type POZ protein (spop) Antikörper
  • speckle type POZ protein S homeolog (spop.S) Antikörper
  • speckle-type POZ protein (Spop) Antikörper
  • speckle type BTB/POZ protein (Spop) Antikörper
  • AI315626 Antikörper
  • BTBD32 Antikörper
  • Pcif1 Antikörper
  • spop Antikörper
  • TEF2 Antikörper
  • zgc:64140 Antikörper

Bezeichner auf Proteinebene für SPOP

speckle-type POZ protein , Speckle-type POZ protein , speckle-type POZ protein-like , HIB homolog 1 , SPOP1 , speckle-type POZ protein B , roadkill homolog 1 , PDX-1 C-terminal-interacting factor 1

GENE ID SPEZIES
394599 Xenopus (Silurana) tropicalis
455106 Pan troglodytes
699711 Macaca mulatta
6104034 Brugia malayi
100390371 Callithrix jacchus
100021911 Monodelphis domestica
100056116 Equus caballus
100195374 Salmo salar
100544737 Meleagris gallopavo
100587478 Nomascus leucogenys
100005514 Danio rerio
779391 Xenopus laevis
425528 Gallus gallus
8405 Homo sapiens
480548 Canis lupus familiaris
530618 Bos taurus
20747 Mus musculus
287643 Rattus norvegicus
100343929 Oryctolagus cuniculus
100713182 Cavia porcellus
101111300 Ovis aries
100173908 Pongo abelii
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