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SP7 encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Zusätzlich bieten wir Ihnen SP7 Antikörper (37) und SP7 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
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Sp7 plays a critical role in limiting the level of signaling and the rate of bone growth
FGF and Wnt (zeige WNT2 ELISA Kits)/beta-Catenin (zeige CTNNB1 ELISA Kits) pathways act in part by directing transcription of osx to promote osteoblast differentiation at sites of bone formation.
Data show the endogenous sp7 gene expression in the otic placode and vesicle, and in forming skeletal structures in Tg(sp7:EGFP)b1212 line.
dissection of these interconnected epigenetic mechanisms that govern Sp7 gene activation reveals a hierarchical process where regulatory components mediating DNA demethylation play a leading role
SP7 gene promoter is robustly enriched in epigenetic repressive marks that may explain its poor transcriptional response to osteoblast differentiating media in umbilical cord derived mesenchymal stem cells.
Eight and five of the nine samples were negative for cell adhesion molecule 1 (zeige CADM1 ELISA Kits) and Osterix respectively. The other markers showed no statistical significance(CD151 (zeige CD151 ELISA Kits),ALP (zeige ALP ELISA Kits)). osteoblastic differentiation can occur in carcinoma cells and that cell adhesion molecule 1 (zeige CADM1 ELISA Kits) could be a useful marker for identifying this phenomenon in carcinoma tissues
The results suggest that Osterix plays an important role in increasing BMP- 4 (zeige BMP4 ELISA Kits)-induced Cx43 (zeige GJA1 ELISA Kits) activity.
The expression of specific targets Smad1 (zeige GARS ELISA Kits) and Osterix was significantly increased in the presence of Pi and restored by coincubation with Mg(2 (zeige MUC7 ELISA Kits)+). As miR (zeige MLXIP ELISA Kits)-30b, miR (zeige MLXIP ELISA Kits)-133a, and miR (zeige MLXIP ELISA Kits)-143 are negatively regulated by Pi and restored by Mg(2 (zeige MUC7 ELISA Kits)+) with a congruent modulation of their known targets Runx2 (zeige RUNX2 ELISA Kits), Smad1 (zeige GARS ELISA Kits), and Osterix, our results provide a potential mechanistic explanation of the observed upregulation of these master switches of o
Preameloblast-Derived Factors Mediate Osteoblast Differentiation of Human Bone Marrow Mesenchymal Stem Cells by Runx2 (zeige RUNX2 ELISA Kits)-Osterix-BSP (zeige KLK6 ELISA Kits) Signaling.
Osx (zeige MID1 ELISA Kits) might function as a potential regulator for the proliferation and odontoblastic differentiation of hDPCs.
Data suggest that beta-catenin (beta-cat) signaling upregulates the expression of osterix (OSX) in pre-osteoblastic and bone marrow stromal cells.
The 2 genes RUNX1 (zeige RUNX1 ELISA Kits) and SP7 resulted differently expressed in cells cultured on metallic supports if compared with the expression recorded for OIC
c-Src (zeige SRC ELISA Kits) signaling modulates osteoblast differentiation at least in part through phosphorylation of Osterix.
The data support a model in which Dlx recruitment of Sp7 to osteoblast enhancers underlies Sp7-directed osteoblast specification.
Mmp13 (zeige MMP13 ELISA Kits) is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (zeige PTH ELISA Kits), and Osterix through distal enhancers.
These results indicated that olfactory bulb development was not significantly impaired in the absence of Osx.
Wnt3a (zeige WNT3A ELISA Kits) induces Osx expression via p38 MAPK (zeige MAPK14 ELISA Kits) signaling in dental follicle cells. Wnt3a (zeige WNT3A ELISA Kits)-induced Osx expression was inhibited in the presence of p38 mitogen-activated protein kinase (zeige MAPK14 ELISA Kits) (MAPK (zeige MAPK1 ELISA Kits)) inhibitors (SB203580 and SB202190) at gene and protein levels, as assessed by real-time PCR and immunocytohistochemistry, respectively.
Transfection assay demonstrated that Osx was able to activate Bsp (zeige KLK6 ELISA Kits) promoter reporter in a dose-dependent manner. To define minimal region of Bsp (zeige KLK6 ELISA Kits) promoter activated by Osx, a series of deletion mutants of Bsp (zeige KLK6 ELISA Kits) promoter were generated, and the minimal region was narrowed down to the proximal 100 bp. Point-mutagenesis studies showed that one GC-rich (zeige RELB ELISA Kits) site was required for Bsp (zeige KLK6 ELISA Kits) promoter activation by Osx.
OSX served a key role in the development and progression of ALD (zeige ABCD1 ELISA Kits)-induced VSMC calcification. This observation may aid in the explanation of the role of OSX in the pathogenesis of vascular calcification
results suggest that expression of Sp7 during the early stage of Satb2 (zeige SATB2 ELISA Kits)-induced osteogenic differentiation of BMSCs is regulated by miR (zeige MLXIP ELISA Kits)-27a.
Fibrillin-2 (zeige FBN2 ELISA Kits) and periostin (zeige POSTN ELISA Kits) are target genes in Osterix-mediated osteoblast differentiation.
osterix is a downstream target of IGF1R (zeige IGF1R ELISA Kits) in chondrocytes.
cells expressing osterix are mesenchymal progenitors contributing to all relevant cell types during morphogenesis.
This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein is a bone specific transcription factor and is required for osteoblast differentiation and bone formation.
transcription factor Sp7
, transcription factor osterix
, Sp7 transcription factor
, transcription factor Sp7-like
, zinc finger protein osterix
, trans-acting transcription factor 7