Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 6 Proteine (SLC9A6)

SLC9A6 encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. Zusätzlich bieten wir Ihnen SLC9A6 Antikörper (30) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Maus SLC9A6 SLC9A6 236794  
Ratte SLC9A6 SLC9A6 302863  
SLC9A6 10479 Q92581
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 56 bis 61 Tage
8.202,81 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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SLC9A6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,

Weitere Proteine zu Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 6 (SLC9A6) Interaktionspartnern

Mouse (Murine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 6 (SLC9A6) Interaktionspartner

  1. analysis of the heterozygous Slc9a6 KO female mice model of X-linked Christianson syndrome

  2. deletion of (370)Trp-Ser-Thr(372) leads to endoplasmic reticulum retention and loss of NHE6 function

  3. Loss of NHE6 results in overacidification of the endosomal compartment and attenuated TrkB (zeige NTRK2 Proteine) signaling.

  4. NHE6 may play a unique, previously unrecognized, role at glutamatergic synapses that are important for learning and memory

  5. Sodium-hydrogen exchanger 6 depletion leads to abnormal accumulation of GM2 (zeige CYB5D2 Proteine) ganglioside and unesterified cholesterol within late endosomes and lysosomes of neurons in selective brain regions.

  6. This review describes Nhe6 knockout mice, which partially mimic phenotypical features of patients suffering from mental disorders including motor hyperactivity and a lowered threshold for pharmacologically induced seizures.

  7. NHE6 is expressed in the inner ear

Human Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 6 (SLC9A6) Interaktionspartner

  1. We describe a large extended family with three affected males, four carrier females, one presumed carrier female and one obligate carrier female with a c.190G>T, p.E64X mutation known to cause a premature stop codon in SLC9A6

  2. Epileptic encephalopathy related to mutations in the SLC9A6 genes.

  3. Data show that co-expression with sodium-hydrogen antiporter NHE6 or treatment with the Na(+)/H(+) ionophore monensin shifted amyloid precursor protein (APP (zeige APP Proteine)) away from the trans-Golgi network into early and recycling endosomes in HEK293 cells.

  4. This study demonistrated that Genetic and phenotypic diversity of NHE6 mutations in Christianson syndrome.

  5. find interesting gene expression changes in endosomal NHE6 and NHE9 (zeige SLC9A9 Proteine) in postmortem autism brains.

  6. Data indicate SLC9A6 mutations and the clinical uniformity of male patients with Christianson syndrome in two familieis.

  7. We report on a 22year-old male patient with Christianson syndrome carrying the novel p.Gln306X mutation in SLC9A6

  8. The involvement of SLC9A6 mutations in 22 males initially suspected to have Angelman syndrome (zeige ube3a Proteine) (AS) but found on genetic testing not to have AS (AS-like cohort), and 104 male patients with X-linked mental retardation (XMR) (XMR cohort), was investigated.

  9. These observations suggest that NHE6 regulates clathrin-dependent endocytosis of transferrin (zeige Tf Proteine) via pH regulation.

  10. In mineralizing osteoblasts, slightly basic basal intracellular pH is maintained, and external acid load is dissipated, by high-capacity Na(+) /H(+) exchange via NHE1 and NHE6.

SLC9A6 Protein Überblick

Protein Überblick

This gene encodes a sodium-hydrogen exchanger that is amember of the solute carrier family 9. The encoded protein localizes to early and recycling endosomes and may be involved in regulating endosomal pH and volume. Defects in this gene are associated with X-linked syndromic mental retardation, Christianson type. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit SLC9A6

  • solute carrier family 9 (sodium/hydrogen exchanger), member 6 (Slc9a6)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 7 (SLC9A7)
  • solute carrier family 9, subfamily A (NHE7, cation proton antiporter 7), member 7 (SLC9A7)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 7 (slc9a7)
  • solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (Slc9a6)
  • solute carrier family 9, subfamily A (NHE6, cation proton antiporter 6), member 6 (SLC9A6)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 6 (SLC9A6)
  • sodium/hydrogen exchanger 6 (PGTG_07402)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 6 (LOC100223682)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 6 (slc9a6)
  • 3732426M05 Protein
  • 6430520C02Rik Protein
  • DKFZp459O1854 Protein
  • mKIAA0267 Protein
  • MRSA Protein
  • NHE6 Protein
  • nhe7 Protein
  • RGD1563582 Protein
  • slc9a6 Protein

Bezeichner auf Proteinebene für SLC9A6

solute carrier family 9 (sodium/hydrogen exchanger) , solute carrier family 9 (sodium/hydrogen exchanger), member 7 , sodium/hydrogen exchanger 7-like , sodium/hydrogen exchanger 6 , solute carrier family 9 (sodium/hydrogen exchanger), member 6 , sodium/hydrogen exchanger 6-like , Na(+)/H(+) exchanger 6

GENE ID SPEZIES
236794 Mus musculus
418676 Gallus gallus
522505 Bos taurus
609144 Canis lupus familiaris
710906 Macaca mulatta
100011742 Monodelphis domestica
100060383 Equus caballus
100151732 Xenopus (Silurana) tropicalis
100390494 Callithrix jacchus
100436764 Pongo abelii
100524182 Sus scrofa
302863 Rattus norvegicus
422241 Gallus gallus
473799 Pan troglodytes
481060 Canis lupus familiaris
533137 Bos taurus
10536554 Puccinia graminis f. sp. tritici CRL 75-36-700-3
100171878 Pongo abelii
100223682 Taeniopygia guttata
100470354 Ailuropoda melanoleuca
100554712 Anolis carolinensis
100588872 Nomascus leucogenys
10479 Homo sapiens
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