Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Proteine (SLC9A3R2)

SLC9A3R2 encodes a member of the NHERF family of PDZ scaffolding proteins. Zusätzlich bieten wir Ihnen Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Antikörper (58) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC9A3R2 65962 Q9JHL1
SLC9A3R2 9351 Q15599
SLC9A3R2 116501 Q920G2
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Showing 5 out of 6 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
649,52 €
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Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.711,59 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.772,70 €
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SLC9A3R2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human
,
Rat (Rattus)

Weitere Proteine zu Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Interaktionspartnern

Zebrafish Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Interaktionspartner

  1. Results strongly support an important role for NHERF1 in the regulation of Planar Cell Polarity signaling and the development of functional motile cilia.

Cow (Bovine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Interaktionspartner

  1. the essential role of NHERF2 in endothelial cell adhesion/migration and angiogenesis. [NHERF2]

Pig (Porcine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Interaktionspartner

  1. Analysis showed that SLC9A3R2 gene has the closest genetic relationship with the SLC9A3R2 gene of human; it is structured in 7 exons and 6 introns; tissue expression analysis indicated that SLC9A3R2 gene is differentially expressed in different tissues.

Mouse (Murine) Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Interaktionspartner

  1. Knockdown of NHERF2 decreased colon cancer progression. NHERF2 deletion attenuated Stat3 (zeige STAT3 Proteine) activation and CD24 (zeige CD24 Proteine) expression in colon cancer cells.

  2. NHERF2 is differentially distributed to lipid rafts in brush border membrane fractions of NHE3 (zeige SLC9A3 Proteine).

  3. involvement of NHERF2 in multiple apical regulatory processes and interactions with luminal contents

  4. NHERF2 is necessary for multiple aspects of acute regulation of NHE3 (zeige SLC9A3 Proteine) in intact mouse small intestine

  5. It was concluded that NHERF2 plays important roles in tethering NHE3 (zeige SLC9A3 Proteine) to a position near the terminal web and in second messenger inhibition of NHE3 (zeige SLC9A3 Proteine) in a signal- and segment-specific fashion.

  6. Lysophosphatidic acid (LPA) is a potent stimulant of NHE3 (zeige SLC9A3 Proteine) and fluid absorption in the intestine, signaling through LPA(5 (zeige LPAR5 Proteine)). Regulation by LPA(5 (zeige LPAR5 Proteine)) depends on its interaction with NHERF2.

  7. demonstration of the significance of SGK1 (zeige SGK1 Proteine) and NHERF2 as TRPV5 (zeige TRPV5 Proteine) modulators which are likely to participate in the regulation of calcium homeostasis by 1,25(OH)2D3

  8. the function of SIP-1/NHERF2 as an SRY (zeige SRY Proteine) cofactor during testis determination is conserved between human and mouse

  9. analysis of NHERF (zeige SLC9A3R1 Proteine) recognition by ERM (zeige ETV5 Proteine) proteins

  10. NHERF-2 and mGluR5 (zeige GRM5 Proteine) exhibit overlapping patterns of expression in mouse brain, where their association prolongs intracellular calcium mobilization by mGluR5 (zeige GRM5 Proteine) and promotes mGluR5 (zeige GRM5 Proteine)-mediated toxicity.

Human Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Interaktionspartner

  1. Moreover, the S303D mutation enhances the in vivo dynamics of the E3KARP tail alone, whereas in vitro the interaction of E3KARP with active ezrin (zeige EZR Proteine) is unaffected by S303D

  2. Lysophosphatidic acid stimulation of NHE3 (zeige SLC9A3 Proteine) exocytosis in polarized epithelial cells occurs with release from NHERF2 via ERK (zeige EPHB2 Proteine)-PLC (zeige HSPG2 Proteine)-PKCdelta (zeige PKCd Proteine) signaling.

  3. Data indicate that the tails promote different microvillar localizations for EBP50 (zeige SLC9A3R1 Proteine) and E3KARP, which localized along the full length and to the base of microvilli, respectively.

  4. Crystal structure of NHERF2 PDZ1 domain complex with C-terminal LPA2 (zeige LPAR2 Proteine) sequence. The PDZ1-LPA2 (zeige LPAR2 Proteine) binding specificity is achieved by hydrogen bonds and hydrophobic contacts with the last four LPA2 (zeige LPAR2 Proteine) residues contributing to specific interactions.

  5. NHERF2 domain was functionally significant in NHE3 (zeige SLC9A3 Proteine) regulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility of NHE3 (zeige SLC9A3 Proteine)

  6. functional regulation of C3aR (zeige C3AR1 Proteine) by NHERFs in human mast cells

  7. AnxA2 (zeige ANXA2 Proteine) and NHERF2 form a scaffold complex that links adjacent Tir molecules at the plasma membrane forming a lattice that could be involved in retention and dissemination of other effectors at the bacterial attachment site.

  8. NHERF-2 is a negative regulator of endothelial proliferation and may have important roles in endothelial homeostasis and vascular modeling.

  9. CaMKII (zeige CAMK2G Proteine) inhibition of NHE3 (zeige SLC9A3 Proteine) reguires NHEF2.

  10. Data show that both NHERF2 and NHERF1 (zeige SLC9A3R1 Proteine) are involved in setting NHE3 (zeige SLC9A3 Proteine) activity.

Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 (SLC9A3R2) Protein Überblick

Protein Überblick

This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit SLC9A3R2

  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1 (slc9a3r1)
  • solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 (SLC9A3R2)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 (SLC9A3R2)
  • solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 (Slc9a3r2)
  • solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2 (Slc9a3r2)
  • 0610011L07Rik Protein
  • 1200011K07Rik Protein
  • 2010007A20Rik Protein
  • cb895 Protein
  • E3KARP Protein
  • NHE3RF2 Protein
  • NHERF-2 Protein
  • NHERF2 Protein
  • OCTS2 Protein
  • SIP-1 Protein
  • SIP1 Protein
  • slc9a3r2 Protein
  • Sryip1 Protein
  • TKA-1 Protein
  • wu:fd20a02 Protein
  • zgc:55541 Protein
  • zgc:77629 Protein

Bezeichner auf Proteinebene für SLC9A3R2

Na(+)/H(+) exchange regulatory cofactor NHE-RF1 , nherf1 , solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulatory factor 2 , solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 2 , Na(+)/H(+) exchange regulatory cofactor NHE-RF2 , solute carrier family 9 isoform 3 regulator 2 , NHE3 kinase A regulatory protein E3KARP , SRY-interacting protein 1 , Sry interacting protein 1 , sodium-hydrogen exchanger regulatory factor 2 , sodium/hydrogen exchanger , solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2 , solute carrier family 9 isoform 3 regulator 2, isoform A; sodium/hydrogen exchanger , solute carrier family 9 isoform A3 regulatory factor 2 , tyrosine kinase activator protein 1 , NHE3 regulatory factor 2 , sodium/hydrogen exchanger 3 kinase A regulatory protein , NHERF-2 , SIP-1 , TKA-1 , PDZ domain containing protein NHERF-2 , PDZ domain-containing protein NHERF-2

GENE ID SPEZIES
327272 Danio rerio
416550 Gallus gallus
479884 Canis lupus familiaris
694658 Macaca mulatta
768005 Bos taurus
100192448 Sus scrofa
65962 Mus musculus
9351 Homo sapiens
116501 Rattus norvegicus
100008813 Oryctolagus cuniculus
Ausgewählte Anbieter für Solute Carrier Family 9 (Sodium/hydrogen Exchanger), Member 3 Regulator 2 Proteine (SLC9A3R2)
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