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SLC6A15 encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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Cow (Bovine) Polyclonal SLC6A15 Primary Antibody für WB - ABIN2781658
Takanaga, Mackenzie, Peng, Hediger: Characterization of a branched-chain amino-acid transporter SBAT1 (SLC6A15) that is expressed in human brain. in Biochemical and biophysical research communications 2005
Our study demonstrates a role for reduced Slc6a15, a neutral amino acid transporter (zeige SLC6A19 Antikörper), in nucleus accumbens (NAc (zeige NLRP1 Antikörper)) in depression and stress susceptibility. The reduction of Slc6a15 occurs selectively in the NAc (zeige NLRP1 Antikörper) D2-neurons. Genetic reduction of Slc6a15 induces susceptibility to a subthreshold stress, while genetic overexpression in D2-neurons prevents social avoidance after chronic social defeat stress.
Slc6a15 plays a role in modulating emotional behavior, possibly mediated by its impact on glutamatergic neurotransmission.
SLC6A15 regulates the activity of the brain glutamatergic system through the proline-glutamate (zeige GRIN1 Antikörper) biosynthesis pathway, affecting hippocampal neurochemistry and consequently behavior.
The structure and function of B0AT2 are reported.
Slc6a15 knockout mice demonstrate only modest alterations in rotarod performance with aging and lack reproducible alterations in other motor, memory, anxiety or olfactory tests
We observed an association between the SLC6A15 rs1545843 and resting-state brain function of the corpus callosum, cingulum and the frontal, parietal, and temporal lobes in MDD patients, which may be involved in the pathogenesis of Major Depressive Disorder. There was no interaction between rs1545843 genotypes and disease status.
This study provides the first evidence that, at least among Han Chinese patients with PD, AA genotype at rs1545843 in the SLC6A15 gene.
an association between the risk allele of the SLC6A15 gene rs1545843 and the White Matter Tracts integrity of the PHC (zeige SLC25A3 Antikörper) in Major Depressive Disorder patients, which is known to play an important role in the neural circuit involved in emotion processing.
The SLC6A15 gene plays a role in adrenocorticotropic hormone (ACTH) and cortisol secretion during cognitive impairments in unipolar depression.
The data from human genetics(SLC6A15), expression studies, brain imaging, and animal models suggest a pathophysiological mechanism for MD that may be accessible to drug targeting.
SBAT1-mediated transport of BCAA (zeige ARID4B Antikörper), particularly leucine, may be an important source of amino nitrogen for neurotransmitter synthesis in glutamatergic and GABAergic neurons.
The substrate profile of the NTT4 (zeige SLC6A17 Antikörper)/XT1 (zeige XYLT1 Antikörper)-dependent activity is similar to that of the closely related B(0)AT2 (zeige AGTR2 Antikörper)/SBAT1 (SLC6A15), including a submillimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine (zeige GFPT1 Antikörper).
This gene encodes a member of the solute carrier family 6 protein family which transports neutral amino acids. The encoded protein is thought to play a role in neuronal amino acid transport (PMID: 16185194) and may be associated with major depression (PMID: 21521612). Multiple transcript variants encoding different isoforms have been found for this gene.
solute carrier family 6 (neutral amino acid transporter), member 15
, solute carrier family 6, member 15
, hypothetical protein
, Sodium- and chloride-dependent neurotransmitter transporter NTT73
, Solute carrier family 6 member 15
, Transporter v7-3
, sodium-dependent neutral amino acid transporter B(0)AT2
, orphan sodium- and chloride-dependent neurotransmitter transporter NTT73-like
, B0AT2 protein
, orphan sodium- and chloride-dependent neurotransmitter transporter NTT73
, orphan transporter v7-3
, sodium- and chloride-dependent neurotransmitter transporter NTT73
, solute carrier family 6 member 15
, transporter v7-3
, homolog of rat orphan transporter v7-3
, sodium-coupled branched-chain amino-acid transporter 1
, sodium/chloride dependent neurotransmitter transporter Homo sapiens orphan neurotransmitter transporter NTT7
, solute carrier family 6 (neurotransmitter transporter), member 15