Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 5 Proteine (SLC6A5)

SLC6A5 encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. Zusätzlich bieten wir Ihnen SLC6A5 Antikörper (17) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC6A5 104245  
SLC6A5 9152 Q9Y345
Ratte SLC6A5 SLC6A5 171148 P58295
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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SLC6A5 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)
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Human ,
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Weitere Proteine zu Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 5 (SLC6A5) Interaktionspartnern

Mouse (Murine) Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 5 (SLC6A5) Interaktionspartner

  1. that the deletion of VIAAT in GlyT2-Cre expressing neurons also strongly affects GABAergic transmission

  2. Results suggest that the excessive GAT-1 and GlyT-1 (zeige GLYT1 Proteine)/2 heterotransporter-mediated Glu (zeige GCG Proteine) release, in the spinal cord of SOD1 (zeige SOD1 Proteine)(G93A) mice, is due to the heterotransporter over-expression at the nerve terminal membrane, promoted by the excessive Glu (zeige GCG Proteine) exocytosis

  3. Report that in the presence of a GlyT2 mechanism-based toxicity, reversible inhibitors might allow a tolerable balance between efficacy and toxicity.

  4. These alterations in the activities and expression profiles of the GlyTs suggest that the contributions of GlyT1 (zeige GLYT1 Proteine) and GlyT2 to the regulation of extracellular glycine concentrations at glycinergic synapses changes during development.

  5. Data show that the GlyT2 protein is undetectable in homozygous mutants, indicating a null allele.

  6. In the first postnatal week, loss of the glycine transporter 2 is neither compensated by glycine de-novo synthesis nor by up-regulation of the GABAergic transmission in GlyT2(-/-) mice.

  7. These data indicate that the C-terminal PDZ-ligand motif of GlyT2 plays an important role in transporter trafficking to and/or stabilization at synaptic sites.

  8. Glyt2-mediated release of glycine from axon terminals involves exocytosis triggered by intraterminal mitochondrial Ca2 (zeige CA2 Proteine)+ ions.

  9. our results demonstrate the central role played by GlyT2 in determining inhibitory phenotype and therefore in the physiology and pathology of inhibitory circuits.

Human Solute Carrier Family 6 (Neurotransmitter Transporter, Glycine), Member 5 (SLC6A5) Interaktionspartner

  1. analysis of the human SLC6A5 (zeige SLC6A2 Proteine) gene mutation associated with hyperekplexia

  2. Report that in the presence of a GlyT2 mechanism-based toxicity, reversible inhibitors might allow a tolerable balance between efficacy and toxicity.

  3. Constitutive endocytosis and turnover of the neuronal glycine transporter GlyT2 is dependent on ubiquitination of a C-terminal lysine cluster.

  4. A novel dominant hyperekplexia mutation Y705C alters trafficking and biochemical properties of the presynaptic glycine transporter GlyT2.

  5. This study firmly establishes the combination of missense, nonsense, frameshift, and splice site mutations in the GlyT2 gene as the second major cause of startle disease.

  6. A transgenic cell line is studied in which green fluorescent protein (GFP) is expressed under the control of the promoter for the glycine transporter GlyT2 during zebrafish development.

  7. Inspiratory-modulated neurons with pacemaker properties are present in the preBotzinger complex of newborn transgenic mice and express the glycine tranporter (GlyT)2 protein.

  8. SLC6A5 (zeige SLC6A2 Proteine) mutations result in defective subcellular GlyT2 localization, decreased glycine uptake or both, with selected mutations affecting predicted glycine and Na+ binding sites.

  9. results are consistent with GLYT2 being a disease gene in human hyperekplexia

  10. SLC6A5 (zeige SLC6A2 Proteine) gene is associated with schizophrenia.

SLC6A5 Protein Überblick

Protein Überblick

This gene encodes a sodium- and chloride-dependent glycine neurotransmitter transporter. This integral membrane glycoprotein is responsible for the clearance of extracellular glycine during glycine-mediated neurotransmission. This protein is found in glycinergic axons and maintains a high presynaptic pool of neurotransmitter at glycinergic synapses. Mutations in this gene cause hyperekplexia\; a heterogenous neurological disorder characterized by exaggerated startle responses and neonatal apnea.

Genbezeichner und Symbole assoziert mit SLC6A5

  • solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (SLC6A5)
  • solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (LOC100339626)
  • solute carrier family 6 (neurotransmitter transporter, glycine), member 5 (Slc6a5)
  • solute carrier family 6 (neurotransmitter transporter), member 5 (SLC6A5)
  • solute carrier family 6 (neurotransmitter transporter), member 5 (Slc6a5)
  • GLYT-2 Protein
  • GLYT2 Protein
  • HKPX3 Protein
  • NET1 Protein
  • prestin Protein
  • SLC6A5 Protein

Bezeichner auf Proteinebene für SLC6A5

solute carrier family 6 (neurotransmitter transporter, glycine), member 5 , sodium- and chloride-dependent glycine transporter 2-like , glyT-2 , glycine transporter 2 , sodium- and chloride-dependent glycine transporter 2 , solute carrier family 6 member 5

GENE ID SPEZIES
422974 Gallus gallus
466470 Pan troglodytes
612095 Canis lupus familiaris
704703 Macaca mulatta
100339626 Oryctolagus cuniculus
100431924 Pongo abelii
100585180 Nomascus leucogenys
104245 Mus musculus
9152 Homo sapiens
171148 Rattus norvegicus
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