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Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Proteine (SLC12A3)

SLC12A3 encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. Zusätzlich bieten wir Ihnen Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Antikörper (66) und Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SLC12A3 6559 P55017
Ratte SLC12A3 SLC12A3 54300 P55018
SLC12A3 20497 P59158
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
426,67 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 16 Days
748,00 €
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HOST_Escherichia coli (E. coli) Human Unkonjugiert   100 μg Anmelden zum Anzeigen 7 bis 14 Tage
595,83 €
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SLC12A3 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) ,
,

Weitere Proteine zu Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) Interaktionspartnern

Human Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) Interaktionspartner

  1. Data show that WNK lysine deficient protein kinase 3 protein (WNK3) interacts with NCC and increases the Na-Cl cotransporter (NCC) expression on the cell membrane and in cytoplasm together.

  2. variants of the SLC12A3 gene confer susceptibility to the abnormal serum LDL-c level in the Mongolian population.

  3. A significant association of the SLC12A3 rs11643718 and ELMO1 (zeige ELMO1 Proteine) rs741301 (Single nucleotide Polymorphism) SNPs with diabetic nephropathy in south Indians.

  4. This paper identified a novel SLC12A3 allele in Gitelman syndrome that activates a cryptic exon flanked by interspersed repeats deep in intron 12.

  5. SLC12A3 gene homozygous mutation is associated with Gitelman syndrome.

  6. SNPs in the SLC12A3 gene confer susceptibility to hypertension in the Mongolian population.

  7. Compared with patients with 1 mutant SLC12A3 allele, patients with 2 mutant SLC12A3 alleles had more severe hypomagnesemia, but did not have more severe hypokalemia.

  8. the results of this study support that the SLC12A3 gene is a susceptibility gene for hypertension in the Mongolian population.

  9. Suggest NCC1 (zeige CCL13 Proteine)/2 is a fully functional thiazide-sensitive NaCl-transporting protein in the kidney.

  10. Low SLC12A3 urine levels were associated with Gitelman syndrome.

Mouse (Murine) Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) Interaktionspartner

  1. Potassium depletion stimulates NCC via phosphorylation and inactivation of the KLHL3 (zeige KLHL3 Proteine) and promoting increased blood pressure.

  2. the increased NCC expression and activation is present in CMA which is highly associated with the enhanced WNK4 (zeige WNK4 Proteine)-SPAK (zeige STK39 Proteine) signal pathway using WNK4 (zeige WNK4 Proteine)-/- and SPAK (zeige STK39 Proteine)-/- mice.

  3. The Role of Epithelial Sodium Channel ENaC (zeige SCNN1A Proteine) and the Apical Cl-/HCO3- Exchanger Pendrin (zeige SLC26A4 Proteine) in Compensatory Salt Reabsorption in the Setting of Na-Cl Cotransporter (NCC) Inactivation.

  4. This study identifies NCC as an IL18 (zeige IL18 Proteine)-binding protein that collaborates with IL18r in cell signaling, inflammatory molecule expression, and experimental atherogenesis.

  5. Slc12a3 mRNA and protein expression levels were upregulated in kidneys of db/db (zeige LEPR Proteine) mice from 6, 12, and 26 weeks at the age.

  6. SPAK (zeige STK39 Proteine)-kinase-deficient mice, which are unable to activate NCC by phosphorylation, use multiple common compensatory mechanisms to blunt natriuresis and chloriuresis and to protect against a major drop in blood pressure.

  7. NCC inhibition stimulates duodenal Ca(2 (zeige CA2 Proteine)+) absorption as well as osteoblast differentiation and bone Ca(2 (zeige CA2 Proteine)+) storage, possibly through a FAK (zeige PTK2 Proteine)/ERK (zeige EPHB2 Proteine) dependent mechanism

  8. P2Y2 (zeige P2RY2 Proteine)-mediated increase of cytoplasmic Ca(2 (zeige CA2 Proteine)+) concentration down-regulates the expression of NCC.

  9. Estradiol, progesterone, and prolactin (zeige PRL Proteine) increase renal NaCl cotransporter phosphorylation and activity.

  10. SPAK (zeige STK39 Proteine) is an important mediator of the increased NCC activation by phosphorylation that occurs in the distal convoluted tubule in response to a low-K(+) diet, but other low-potassium-activated kinases are likely to be involved.

Solute Carrier Family 12 (Sodium/Chloride Transporters), Member 3 (SLC12A3) Protein Überblick

Protein Überblick

This gene encodes a renal thiazide-sensitive sodium-chloride cotransporter that is important for electrolyte homeostasis. This cotransporter mediates sodium and chloride reabsorption in the distal convoluted tubule. Mutations in this gene cause Gitelman syndrome, a disease similar to Bartter's syndrome, that is characterized by hypokalemic alkalosis combined with hypomagnesemia, low urinary calcium, and increased renin activity associated with normal blood pressure. This cotransporter is the target for thiazide diuretics that are used for treating high blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SLC12A3

  • solute carrier family 12 (sodium/chloride transporters), member 3 (SLC12A3)
  • thiazide-sensitive sodium chloride cotransporter (NCCT)
  • solute carrier family 12 (sodium/chloride transporters), member 3, gene 2 (slc12a3.2)
  • solute carrier family 12 (sodium/chloride transporter), member 3 (SLC12A3)
  • solute carrier family 12 (sodium/chloride transporter), member 3 (Slc12a3)
  • solute carrier family 12, member 3 (Slc12a3)
  • AI035291 Protein
  • DKFZp469N2315 Protein
  • NCC Protein
  • NCCT Protein
  • slc12a3 Protein
  • TSC Protein

Bezeichner auf Proteinebene für SLC12A3

solute carrier family 12 (sodium/chloride transporters), member 3 , thiazide-sensitive sodium chloride cotransporter , solute carrier family 12 (sodium/chloride transporters), member 3, gene 2 , solute carrier family 12 member 3-like , Na-Cl cotransporter , Na-Cl symporter , NaCl electroneutral thiazide-sensitive cotransporter , solute carrier family 12 member 3 , thiazide-sensitive Na-Cl cotransporter , thiazide-sensitive sodium-chloride cotransporter , solute carrier family 12, member 3 , sodium chloride cotransporter

GENE ID SPEZIES
415692 Gallus gallus
454108 Pan troglodytes
703090 Macaca mulatta
100009348 Oryctolagus cuniculus
100038063 Xenopus (Silurana) tropicalis
100051953 Equus caballus
100172399 Pongo abelii
100409101 Callithrix jacchus
100468795 Ailuropoda melanoleuca
100015656 Monodelphis domestica
6559 Homo sapiens
54300 Rattus norvegicus
478118 Canis lupus familiaris
404171 Bos taurus
20497 Mus musculus
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