Sodium Channel, Voltage-Gated, Type IX, alpha Subunit Proteine (SCN9A)

SCN9A encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Zusätzlich bieten wir Ihnen SCN9A Antikörper (97) und SCN9A Kits (11) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SCN9A 20274  
Ratte SCN9A SCN9A 78956 O08562
SCN9A 6335 Q15858
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Showing 5 out of 11 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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SCN9A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) ,

Human , ,
,

Weitere Proteine zu Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaktionspartnern

Cow (Bovine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaktionspartner

  1. TNF-alpha (zeige TNF Proteine) up-regulates NaV1.7 mRNA in both adrenal chromaffin cells and dorsal root ganglia (DRG) neurons, highlighting the peripheral nociceptive mechanism of TNF-alpha (zeige TNF Proteine)

  2. Findings suggest that the endothelin-1 (zeige EDN1 Proteine)-induced down-regulation of NaV1.7 (SCN9A) diminishes NaV1.7-related catecholamine secretion and dephosphorylation of tau.

  3. Nav1.7-Ca2 (zeige CA2 Proteine)+ influx-induced increased phosphorylations of extracellular signal-regulated kinase (ERK (zeige MAPK1 Proteine)) and p38 (zeige MAPK14 Proteine) attenuate tau phosphorylation via glycogen synthase kinase-3beta: priming of Nav1.7 gating by ERK (zeige MAPK1 Proteine) and p38 (zeige MAPK14 Proteine)

  4. constitutively phosphorylated/activated ERK (zeige MAPK1 Proteine) destabilizes Na(+) channel alpha-subunit (zeige POLG Proteine) mRNA via translational event, which negatively regulates steady-state level of alpha-subunit (zeige POLG Proteine) mRNA and cell surface expression of functional Na(+) channels.

  5. Na influx via scn9a converged on inhibitory phosphorylation of glycogen synthase kinase-3beta, decreasing tau phosphorylation

Mouse (Murine) Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaktionspartner

  1. the FGF13 (zeige FGF13 Proteine)/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals

  2. this paper shows that Nav1.7, by coupling with CRMP1 (zeige CRMP1 Proteine), mediates the axonal retrograde signaling of Sema3A (zeige SEMA3A Proteine) in axonal guidance

  3. Experiments show that integration of synaptic inputs over time by Nav1.7 is critical for body weight regulation and reveal a mechanism for synaptic control of circuits regulating long term homeostatic functions.

  4. Nav1.7 deletion has profound effects on gene expression, leading to an upregulation of enkephalin precursor Penk (zeige PENK Proteine) mRNA and met-enkephalin protein in sensory neurons.

  5. Global Nav1.7 knockouts showed no defects in mechanical sensitivity or overall movement yet were completely insensitive to painful tactile, thermal, and chemical stimuli and were anosmic.

  6. Sodium channel Nav1.7, encoded by SCN9A, is expressed in DRG neurons and regulates their excitability.

  7. a novel regulatory mechanism that utilizes CRMP2 (zeige DPYSL2 Proteine) SUMOylation to choreograph NaV1.7 trafficking.

  8. Behavioural deficits in Nav1.7/Nav1.8 (zeige SCN10A Proteine) knockout mice reflects a failure of action potential propagation in a mechanosensitive set of sensory neurons rather than a loss of primary transduction currents.

  9. Deleting SCN9A in both sensory and sympathetic neurons abolishes pain sensations.

  10. These results demonstrate increased expression levels of Nav1.7, Nav1.8 (zeige SCN10A Proteine), and perhaps Nav1.1 (zeige SCN1A Proteine) in the dorsal root ganglia in mice with a heterozygous mutation of the Nf1 (zeige NF1 Proteine) gene

Human Sodium Channel, Voltage-Gated, Type IX, alpha Subunit (SCN9A) Interaktionspartner

  1. the FGF13 (zeige FGF13 Proteine)/Nav1.7 complex is essential for sustaining the transmission of noxious heat signals

  2. This study showed that gain-of-function attributes at the channel level and differential effects of physiologically relevant thermal stimuli on the excitability of DRG neurons expressing mutant and WT Nav1.7 channels, suggesting a cellular mechanism for warmth-triggered pain episodes in Erythromelalgia patients.

  3. The four congenital insensitivity to pain families, while not closely related, belong to the same ethnic group and clan (zeige NLRC4 Proteine), and the SCN9A mutation may be specific, if not unique to this group

  4. A novel Nav1.9 (zeige SCN11A Proteine) mutation, p.Arg222His, was identified in patients with early-onset pain in distal extremities including joints and gastrointestinal disturbances, but was absent from an asymptomatic blood relative.

  5. Gain-of-function mutation of a voltage-gated sodium channel NaV1.7 associated with peripheral pain and impaired limb development

  6. Results indicate that Nav 1.7 promotes gastric cancer progression through MACC1 (zeige MACC1 Proteine)-mediated upregulation of NHE1 (zeige SLC9A1 Proteine).

  7. report the engineering of highly potent and selective inhibitors of the Nav1.7 channel based on tarantula ceratotoxin-1 (CcoTx1). We utilized a combination of directed evolution, saturation mutagenesis, chemical modification, and rational drug design to obtain higher potency and selectivity to the Nav1.7 channel

  8. Mutant cycle analysis with modified saxitoxins reveals specific interactions critical to attaining high-affinity inhibition of human NaV1.7.

  9. Postoperative pain was affected by SCN9A genetic variability in gynecological surgical patients.

  10. Patients with the SCN9A mutation with inherited erythromelalgia were characterized for the pain phenotype among individuals.

SCN9A Protein Überblick

Protein Überblick

This gene encodes a voltage-gated sodium channel which plays a significant role in nociception signaling. Mutations in this gene have been associated with primary erythermalgia, channelopathy-associated insensitivity to pain, and paroxysmal extreme pain disorder.

Genbezeichner und Symbole assoziert mit SCN9A

  • sodium channel, voltage-gated, type IX, alpha subunit (SCN9A)
  • sodium channel, voltage-gated, type IX, alpha (Scn9a)
  • DKFZp459G084 Protein
  • ETHA Protein
  • FEB3B Protein
  • GEFSP7 Protein
  • mKIAA4197 Protein
  • Nav1.7 Protein
  • NE-NA Protein
  • NENA Protein
  • PN1 Protein
  • Scn2a Protein
  • SCN9A Protein
  • SFNP Protein

Bezeichner auf Proteinebene für SCN9A

sodium channel, voltage-gated, type IX, alpha subunit , sodium channel protein type 9 subunit alpha-like , peripheral sodium channel 1 , sodium channel 25 , sodium channel protein type 9 subunit alpha , sodium channel protein type IX subunit alpha , sodium channel, voltage-gated, type IX, alpha polypeptide , voltage-gated sodium channel alpha subunit Nav1.7 , voltage-gated sodium channel subunit alpha Nav1.7 , sodium channel, voltage-gated, type 9, alpha polypeptide , hNE-Na , neuroendocrine sodium channel , nas , schwann cell sodium channel , sodium channel alpha-subunit

GENE ID SPEZIES
488381 Canis lupus familiaris
533065 Bos taurus
100016648 Monodelphis domestica
100172961 Pongo abelii
100385702 Callithrix jacchus
100482886 Ailuropoda melanoleuca
100516701 Sus scrofa
100583836 Nomascus leucogenys
20274 Mus musculus
78956 Rattus norvegicus
6335 Homo sapiens
100009210 Oryctolagus cuniculus
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