Sirtuin 2 Proteine (SIRT2)

SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 2 Antikörper (127) und Sirtuin 2 Kits (29) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIRT2 22933 Q8IXJ6
SIRT2 64383 Q8VDQ8
SIRT2 361532 Q5RJQ4
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
Escherichia coli (E. coli) Human His tag 10 μg Anmelden zum Anzeigen 15 bis 19 Tage
Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Pongo abelii His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Hefe Macaca fascicularis His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
Escherichia coli (E. coli) Ratte His tag   100 μg Anmelden zum Anzeigen 15 bis 18 Tage

SIRT2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine) ,
Rat (Rattus) ,

Weitere Proteine zu Sirtuin 2 (SIRT2) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Sirtuin 2 (SIRT2) Interaktionspartner

  1. Sirt2 has an role in the regulation of mitochondrial energy metabolism.

Arabidopsis thaliana Sirtuin 2 (SIRT2) Interaktionspartner

  1. SRT2 is important in fine-tuning mitochondrial energy metabolism.

  2. AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 (zeige TMEM37 Proteine) expression.

Human Sirtuin 2 (SIRT2) Interaktionspartner

  1. The SIRT2 functions as a mitochondrial sirtuin (zeige SIRT1 Proteine), as well as a regulator of autophagy/mitophagy to maintain mitochondrial biology, thus facilitating cell survival.

  2. increased expression of SRF that was observed in the aged heart may affect SIRT2 gene expression and contribute to altered metabolic status in senescence

  3. SIRT2 and RIPK1 (zeige RIPK1 Proteine) were localized to the syncytiotrophoblast, villous leukocytes and vasculature in all preterm placentas. A significant reduction in SIRT2 protein expression in both preeclampsia and fetal growth restricted placentas was identified. Immunofluorescence identified both SIRT2 and RIPK1 (zeige RIPK1 Proteine) in the cytotrophoblast cytoplasm.

  4. mutations in sirtuin2 increase the stability of the conserved catalytic sirtuin (zeige SIRT1 Proteine) domain, thereby increasing the catalytic efficiency of the mutant enzymes.

  5. targeting SIRT2 may be a rational strategy for diminishing Slug abundance and its associated malignant traits in basal-like breast cancer.

  6. BEX4 (zeige BEX4 Proteine) overexpression causes an imbalance between TUB (zeige TUB Proteine) acetylation and deacetylation by SIRT2 inhibition and induces oncogenic aneuploidy transformation.

  7. SIRT2 maintains cellular iron levels by binding to and deacetylating nuclear factor erythroid-derived 2 (zeige NFE2 Proteine)-related factor 2 (NRF2 (zeige GABPA Proteine)) on lysines 506 and 508, leading to a reduction in total and nuclear NRF2 (zeige GABPA Proteine) levels.

  8. Identify the miR (zeige MLXIP Proteine)-200c-SIRT2 axis as a key regulator of metabolic reprogramming (Warburg-like effect), via regulation of glycolytic enzymes, during human induced pluripotency and pluripotent stem cell function.

  9. Four novel heterozygous DNA sequence variants and five SNPs of sirt2 protein were found in both acute myocardial infarction patients and control with similar frequencies.

  10. These results indicate overlapping and distinct functions of HDAC6 (zeige HDAC6 Proteine) and SIRT2.

Cow (Bovine) Sirtuin 2 (SIRT2) Interaktionspartner

  1. The results indicate that the variations in the class I sirtuin (zeige SIRT1 Proteine) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (zeige CALCA Proteine)-) diplotypes performed better than other combinations.

  3. Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.

Mouse (Murine) Sirtuin 2 (SIRT2) Interaktionspartner

  1. AMPK (zeige PRKAA1 Proteine) and Sirt2 control compensatory glucose uptake in metabolically arrested mitochondria.

  2. SIRT2 promotes AMPK (zeige PRKAA1 Proteine) activation by deacetylating the kinase LKB1 (zeige STK11 Proteine). Loss of SIRT2 reduces AMPK (zeige PRKAA1 Proteine) activation, promotes aging-related and Ang II (zeige AGT Proteine)-induced cardiac hypertrophy, and blunts metformin-mediated cardioprotective effects.

  3. found a decreased ratio of dopaminergic neurons in primary midbrain cultures treated with the SIRT2 inhibitor AK-7 (zeige AK7 Proteine)

  4. mitochondrial dysfunction triggers LKB1 (zeige STK11 Proteine)-mediated AMPK (zeige PRKAA1 Proteine) activation, which stimulates Sirt2 phosphorylation, leading to activation of mTOR (zeige FRAP1 Proteine)-RAPTOR (zeige RPTOR Proteine) and Glut1 (zeige SLC2A1 Proteine)-mediated glucose uptake.

  5. SIRT-2 regulates microvascular inflammation in obese mice with sepsis.

  6. Loss of SIRT2 expression is associated with breast Cancer.

  7. Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  8. QKI (zeige QKI Proteine) directly plays a crucial role in the post-transcriptional regulation and expression of Sirt2 to facilitate oligodendrocyte differentiation.

  9. Sirt2-knockout mice were less susceptible to the development of hepatic fibrosis induced by carbon tetrachloride or thioacetamide.

  10. Results suggest a role for Hdac5 (zeige HDAC5 Proteine) and Sirt2 in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression

Sirtuin 2 (SIRT2) Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

Genbezeichner und Symbole assoziert mit Sirtuin 2 Proteine (SIRT2)

  • Sirtuin 2 (Sirt2)
  • sirtuin 2 (SIRT2)
  • sirtuin 2 S homeolog (sirt2.S)
  • NAD-dependent deacetylase sirtuin 2 homolog (Sirt2)
  • sirtuin 2 (SRT2)
  • sirtuin 2 (sirt2)
  • sirtuin 2 (Sirt2)
  • sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) (sirt2)
  • 5730427M03Rik Protein
  • AtSRT2 Protein
  • BmSirt2 Protein
  • CG5085 Protein
  • D.mel2 Protein
  • Dmel\\CG5085 Protein
  • dSIRT2 Protein
  • SIR2 Protein
  • Sir2l Protein
  • SIR2L2 Protein
  • Sirt2 Protein
  • sirtuin 2 Protein
  • T2K12.8 Protein
  • wu:fb57d05 Protein
  • zgc:55966 Protein
  • zgc:77003 Protein

Bezeichner auf Proteinebene für Sirtuin 2 Proteine (SIRT2)

CG5085-PA , Sirt2-PA , sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin 2 , NAD-dependent deacetylase SIRT2 , NAD-dependent deacetylase sirtuin-2 , histone NADC , silent information regulator 2 , nicotinamide adenine dinucleotide-dependent histone deacetylase , NAD-dependent deacetylase sirtuin 2 homolog , NAD-dependent protein deacetylase sirtuin-2 , SIR2-like protein 2 , regulatory protein SIR2 homolog 2 , sir2-related protein type 2 , sirtuin type 2 , sirtuin-like protein 2 , mSIR2L2 , silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2 , 5E5 antigen

42414 Drosophila melanogaster
456013 Pan troglodytes
495688 Xenopus laevis
548628 Gallus gallus
612558 Canis lupus familiaris
692483 Bombyx mori
830782 Arabidopsis thaliana
100380582 Salmo salar
22933 Homo sapiens
100125964 Sus scrofa
504463 Bos taurus
64383 Mus musculus
361532 Rattus norvegicus
100172430 Pongo abelii
322309 Danio rerio
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