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Sirtuin 2 Proteine (SIRT2)

SIRT2 encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Zusätzlich bieten wir Ihnen Sirtuin 2 Antikörper (124) und Sirtuin 2 Kits (23) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SIRT2 22933 Q8IXJ6
SIRT2 64383 Q8VDQ8
SIRT2 361532 Q5RJQ4
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Showing 10 out of 20 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Human His tag 10 μg Anmelden zum Anzeigen 11 bis 15 Tage
303,81 €
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HOST_Escherichia coli (E. coli) Human His tag 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
488,89 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.811,11 €
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Hefe Pongo abelii His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.818,10 €
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Hefe Zebrafisch His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.896,67 €
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Hefe Macaca fascicularis His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.924,60 €
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HOST_Escherichia coli (E. coli) Ratte His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
883,81 €
Details

SIRT2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine) ,
,
Rat (Rattus) ,

Am meisten referenzierte Sirtuin 2 Proteine

  1. Human SIRT2 Protein expressed in Escherichia coli (E. coli) - ABIN667280 : North, Marshall, Borra, Denu, Verdin: The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase. in Molecular cell 2003 (PubMed)
    Zeige alle 2 Referenzen für ABIN667280

Weitere Proteine zu Sirtuin 2 (SIRT2) Interaktionspartnern

Fruit Fly (Drosophila melanogaster) Sirtuin 2 (SIRT2) Interaktionspartner

  1. Sirt2 has an role in the regulation of mitochondrial energy metabolism.

Arabidopsis thaliana Sirtuin 2 (SIRT2) Interaktionspartner

  1. SRT2 is important in fine-tuning mitochondrial energy metabolism.

  2. AtSRT2 is a deacetylase that negatively regulates the plant basal defense and PR1 (zeige TMEM37 Proteine) expression.

Human Sirtuin 2 (SIRT2) Interaktionspartner

  1. Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  2. the tissue from lymph node metastases appears to have a significant upregulation of SIRT2 relative to primary tumors across the nuclear, cytoplasmic, and whole cell data.

  3. Data show that SIRT2 interacts with multiple intracellular trafficking proteins and showed that majority of its interactions are of transient nature. Also, It confirms its colocalization with ER-Golgi intermediate compartment.

  4. The levels of SPOP (zeige SPOP Proteine) significantly decreased, while the levels of SIRT2 significantly increased in non-small cell lung cancer (NSCLC) cell lines, compared to normal bronchial epithelial cell line and NSCLC specimens, compared to the paired non-tumor lung tissue.

  5. SIRT2 is a promising marker of cellular senescence at least in cells with wild type p53 (zeige TP53 Proteine) status.

  6. The results suggest that Sirt2 plays a crucial role in neuronal differentiation via the ERK (zeige EPHB2 Proteine)-CREB (zeige CREB1 Proteine) signaling pathway.

  7. Reduced SIRT2 expression during tumorigenesis failed to repress cyclindependent kinase 4 expression, which eventually led to accelerated cell proliferation.

  8. Sirt-2 is recruited to NF-kappaB (zeige NFKB1 Proteine) target gene promoter via interaction with core histones.

  9. Study demonstrate that PRL (zeige PRL Proteine) is necessary for the survival of (retinal pigment epithelium) RPE (zeige RPE Proteine) under normal and advancing age conditions and, identified SIRT2 and TRPM2 (zeige CLU Proteine) as molecular targets for the antioxidant and antiapoptotic actions of PRL (zeige PRL Proteine) in the RPE (zeige RPE Proteine).

  10. 4-oxo-2-nonenal reacts with histone lysine residues to form a new histone modification, gamma-oxononanoylation (Kgon). human Sirt2 catalyzes the removal of histone Kgon.

Cow (Bovine) Sirtuin 2 (SIRT2) Interaktionspartner

  1. The results indicate that the variations in the class I sirtuin (zeige SIRT1 Proteine) genes and their corresponding genotypes may be considered as molecular markers for economic traits in cattle breeding.

  2. An association analysis showed that the two loci of SIRT2 were significantly correlated with some body size traits and the H2H2 (-CT-CT (zeige CALCA Proteine)-) diplotypes performed better than other combinations.

  3. Data suggest that the silent information regulator 2 (SIRT2) gene may be a candidate gene for marker-assisted selection in the development of breeding programs for Qinchuan cattle.

Mouse (Murine) Sirtuin 2 (SIRT2) Interaktionspartner

  1. Genetic manipulation of sirtuin 2 levels in vitro and in vivo modulates the levels of alpha-synuclein acetylation, its aggregation, and autophagy.

  2. QKI (zeige QKI Proteine) directly plays a crucial role in the post-transcriptional regulation and expression of Sirt2 to facilitate oligodendrocyte differentiation.

  3. Sirt2-knockout mice were less susceptible to the development of hepatic fibrosis induced by carbon tetrachloride or thioacetamide.

  4. Results suggest a role for Hdac5 (zeige HDAC5 Proteine) and Sirt2 in neuronal adaptations induced by chronic stress and antidepressant treatment and highlight the therapeutic potential of these targets in the treatment of depression

  5. Sirt2 deletion results in radiation-induced alteration of the mouse brain proteome.

  6. Sirt2 expression has a transitory effect in M. tuberculosis infection

  7. we postulate that Sirt2 mediates myelin-dependent neuronal dysfunction during the early phase after ischemic stroke

  8. The study reports the formation of a multiprotein complex at the G2-to-M transition in vitro and in vivo. Group IVA cytosolic phospholipase A2 (cPLA2-alpha (zeige PLA2G4A Proteine)) acts as a bridge in this complex to promote binding of SIRT2 to cyclin A (zeige CCNA2 Proteine)-Cdk2 (zeige CDK2 Proteine).

  9. Lipopolysaccharide-induced increases in microglia NOS and cytokine mRNA were attenuated in the cells with SIRT2 silencing-produced decreases in the SIRT2 level. This suggests that SIRT2 is required for lipopolysaccharide-induced microglial activation

  10. Disruption of the SIRT2-beta-catenin (zeige CTNNB1 Proteine) interaction represents an endogenous therapeutic target to prevent transformation and preserve the integrity of aging cells against exogenous stressors such as reactive oxygen species.

Sirtuin 2 (SIRT2) Protein Überblick

Protein Überblick

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined\; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Several transcript variants are resulted from alternative splicing of this gene.

Genbezeichner und Symbole assoziert mit Sirtuin 2 Proteine (SIRT2)

  • CG5085 gene product from transcript CG5085-RA (Sirt2)
  • sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) (SIRT2)
  • sirtuin 2 (sir2)
  • sirtuin 2 (SIRT2)
  • NAD-dependent deacetylase sirtuin 2 homolog (Sirt2)
  • sirtuin 2 (SRT2)
  • sirtuin 2 (silent mating type information regulation 2, homolog) 2 (S. cerevisiae) (sirt2)
  • sirtuin 2 (Sirt2)
  • 5730427M03Rik Protein
  • AtSRT2 Protein
  • BmSirt2 Protein
  • CG5085 Protein
  • D.mel2 Protein
  • Dmel\\CG5085 Protein
  • dSIRT2 Protein
  • SIR2 Protein
  • Sir2l Protein
  • SIR2L2 Protein
  • Sirt2 Protein
  • sirtuin 2 Protein
  • T2K12.8 Protein
  • wu:fb57d05 Protein
  • zgc:55966 Protein
  • zgc:77003 Protein

Bezeichner auf Proteinebene für Sirtuin 2 Proteine (SIRT2)

CG5085-PA , Sirt2-PA , sirtuin (silent mating type information regulation 2 homolog) 2 (S. cerevisiae) , sirtuin 2 , NAD-dependent deacetylase SIRT2 , NAD-dependent deacetylase sirtuin-2 , histone NADC , silent information regulator 2 , nicotinamide adenine dinucleotide-dependent histone deacetylase , NAD-dependent deacetylase sirtuin 2 homolog , NAD-dependent protein deacetylase sirtuin-2 , SIR2-like protein 2 , regulatory protein SIR2 homolog 2 , sir2-related protein type 2 , sirtuin type 2 , sirtuin-like protein 2 , mSIR2L2 , silent mating type information regulation 2, (S.cerevisiae, homolog)-like; sirtuin 2 , 5E5 antigen

GENE ID SPEZIES
42414 Drosophila melanogaster
456013 Pan troglodytes
495688 Xenopus laevis
548628 Gallus gallus
612558 Canis lupus familiaris
692483 Bombyx mori
830782 Arabidopsis thaliana
100380582 Salmo salar
22933 Homo sapiens
100125964 Sus scrofa
504463 Bos taurus
64383 Mus musculus
361532 Rattus norvegicus
100172430 Pongo abelii
322309 Danio rerio
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