Signal Peptide Peptidase-Like 2A Proteine (SPPL2A)

SPPL2A encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. Zusätzlich bieten wir Ihnen SPPL2A Antikörper (24) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
Ratte SPPL2A SPPL2A 311401  
SPPL2A 84888 Q8TCT8
SPPL2A 66552 Q9JJF9
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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SPPL2A Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine) ,
,

Weitere Proteine zu Signal Peptide Peptidase-Like 2A (SPPL2A) Interaktionspartnern

Human Signal Peptide Peptidase-Like 2A (SPPL2A) Interaktionspartner

  1. Study propose that elements within the transmembrane segment and the luminal juxtamembrane domain facilitate intramembrane proteolysis of CD74 (zeige CD74 Proteine) by SPPL2a.

  2. In human B cells, SPPL2a is indispensable for turnover of CD74 (zeige CD74 Proteine) N-terminal fragment. A human 15q21.2 microdeletion leads to loss of SPPL2a transcript and protein.

  3. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).

  4. Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes.

  5. SPP, SPPL2a, -2b, -2c, and -3 probably cleave type II-oriented substrate peptides as shown by consensus analysis

  6. ADAM10 (zeige ADAM10 Proteine) and SPPL2a were identified as two proteases implicated in FasL (zeige FASL Proteine) processing and release of the FasL (zeige FASL Proteine) intracellular domain, which has been shown to be important for retrograde FasL (zeige FASL Proteine) signaling

  7. SPPL2a and SPPL2b (zeige SPPL2B Proteine) mediate the intramembrane cleavage, whereas neither SPP nor SPPL3 is capable of processing the Bri2 (zeige ITM2B Proteine) N-terminal fragment.

Mouse (Murine) Signal Peptide Peptidase-Like 2A (SPPL2A) Interaktionspartner

  1. Study propose that elements within the transmembrane segment and the luminal juxtamembrane domain facilitate intramembrane proteolysis of CD74 (zeige CD74 Proteine) by SPPL2a.

  2. SPPL2a-mediated processing of CD74 (zeige CD74 Proteine) NTF (zeige TNF Proteine) is indispensable to maintain appropriate levels of tonic BCR (zeige BCR Proteine) signaling to promote B cell maturation (zeige TNFRSF17 Proteine).

  3. Regulated intramembrane proteolysis of the frontotemporal lobar degeneration risk factor, TMEM106B, by signal peptide peptidase-like 2a (SPPL2a).

  4. in vivo SPPL2a, but not SPPL2b (zeige SPPL2B Proteine), exhibit a physiologically relevant contribution to CD74 (zeige CD74 Proteine) proteolysis in B and dendritic cells

  5. intramembrane proteolysis by SPPL2A is essential for maintaining cellular homeostasis of ameloblasts.

  6. Sppl2a is required for B cell and dendritic cells development and survival.

  7. Sppl2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain.

  8. B cell survival and dendritic cells function requires SPPL2A.

  9. Data show that endogenous SPPL2a - in agreement with overexpression studies - is localised in membranes of lysosomes/late endosomes.

SPPL2A Protein Überblick

Protein Überblick

This gene encodes a member of the GXGD family of aspartic proteases, which are transmembrane proteins with two conserved catalytic motifs localized within the membrane-spanning regions, as well as a member of the signal peptide peptidase-like protease (SPPL) family. This protein is expressed in all major adult human tissues and localizes to late endosomal compartments and lysosomal membranes. A pseudogene of this gene also lies on chromosome 15.

Genbezeichner und Symbole assoziert mit SPPL2A

  • signal peptide peptidase-like 2A (Sppl2a)
  • signal peptide peptidase-like 2A (RCJMB04_13a21)
  • signal peptide peptidase-like 2A (LOC453430)
  • signal peptide peptidase-like 2A (sppl2a)
  • signal peptide peptidase-like 2A (LOC100231183)
  • signal peptide peptidase-like 2A (LOC100348259)
  • Signal peptide peptidase-like 2A (psl2)
  • signal peptide peptidase like 2A (SPPL2A)
  • signal peptide peptidase like 2A (Sppl2a)
  • 2010106G01Rik Protein
  • C130089K23Rik Protein
  • IMP3 Protein
  • LOC453430 Protein
  • LOC100231183 Protein
  • PSL2 Protein
  • RGD1563001 Protein
  • SPPL2A Protein

Bezeichner auf Proteinebene für SPPL2A

signal peptide peptidase-like 2A , Signal peptide peptidase-like 2A , IMP-3 , SPP-like 2A , intramembrane cleaving protease , intramembrane protease 3 , presenilin-like protein 2 , SPP-like 2A protein , protein SPPL2a

GENE ID SPEZIES
311401 Rattus norvegicus
415450 Gallus gallus
453430 Pan troglodytes
100135083 Xenopus (Silurana) tropicalis
100231183 Taeniopygia guttata
100348259 Oryctolagus cuniculus
100380541 Salmo salar
84888 Homo sapiens
66552 Mus musculus
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