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SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Proteine (SMARCB1)

The protein encoded by SMARCB1 is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. Zusätzlich bieten wir Ihnen SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Antikörper (133) und SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SMARCB1 6598 Q12824
SMARCB1 20587 Q9Z0H3
Ratte SMARCB1 SMARCB1 361825  
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Showing 7 out of 20 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Anmelden zum Anzeigen 15 bis 16 Tage
324,76 €
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Hefe Human His tag   50 μg Anmelden zum Anzeigen 12 bis 16 Tage
324,76 €
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HOST_Baculovirus infected Insect Cells Human His tag   20 μg Anmelden zum Anzeigen 6 bis 8 Tage
864,29 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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SMARCB1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, , ,
Mouse (Murine)

Weitere Proteine zu SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Interaktionspartnern

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Interaktionspartner

  1. Rpt1 domain of INI1 may participate in ubiquitin recognition or binding with ubiquitin or ubiquitin related proteins.

  2. Here, the authors first confirmed that SWIRM domain of BAF155 is responsible for its interaction with BAF47 and then narrowed down the SWIRM-binding region in BAF47 to the Repeat 1 (RPT1) domain.

  3. Our results suggest a general role of miR (zeige MLXIP Proteine)-206,-381, and 671-5p in SMARCB1 gene silencing of epithelioid sarcomas(ES) , extraskeletal myxoid chondrosarcomas , malignant peripheral nerve sheath tumors and synovial sarcomas . In the future, miR (zeige MLXIP Proteine)-765 could possibly be a diagnostic tool for ES because of its 97% specificity and 80% sensitivity.

  4. We conclude that in the context of 22q11-12 regional alterations present in SMARCB1-deleted tumors, simultaneous EWSR1 (zeige EWSR1 Proteine) involvement may be misinterpreted as equivalent to EWSR1 (zeige EWSR1 Proteine) rearrangement. A detailed clinicopathologic correlation and supplementing the EWSR1 (zeige EWSR1 Proteine) FISH assay with complementary methodology is mandatory for correct diagnosis

  5. SNF5 is indispensable for CRIF1 (zeige GADD45GIP1 Proteine)-enhanced p53 (zeige TP53 Proteine) activity and its function in the suppression of cell cycle arrest in human cancer cells.

  6. INI1 re-expression suppresses cell proliferation and MYC (zeige MYC Proteine)-potentiated transformation.

  7. Interfering INI1 or the INI1-SAP18 (zeige SAP18 Proteine) interaction leads to the impairment of these processes.

  8. For the first time, we performed analysis of DNA methylation (zeige HELLS Proteine) in SMARCB1/INI1-deficient sinonasal carcinomas, reporting on significantly higher methylation of RASSF1 (zeige RASSF1 Proteine) gene in this neoplasm.

  9. reporting involvement of the SWI (zeige SMARCA1 Proteine)/SNF (zeige SNRPA Proteine) complex in the dedifferentiation process of a variety of epithelial neoplasms in different organs, including the urinary tract, and association with aggressive clinical course

  10. Case Report: renal cell carcinoma (zeige MOK Proteine) with Xp11.2 translocation, TFE3 (zeige TFE3 Proteine) rearrangement and SMARCB1 inactivation in end stage renal disease patient.

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Interaktionspartner

  1. The occurrence of intracranial rhabdoid tumours depends on control of Smarcb1 inactivation.

  2. These results support recent findings regarding the effectivity of EGFR (zeige EGFR Proteine) inhibitors in hindering the proliferation of human MRT cells and demonstrate that activation of EGFR (zeige EGFR Proteine) signaling in Rhabdoid tumors is SMARCB1 dependent.

  3. these findings uncover a novel role for Snf5 in oligodendrocyte generation and survival, and they offer evidence of the first genetically engineered mouse model for AT/RT in the CNS.

  4. This study show here that loss of Smarcb1 and Smarca4 (zeige SMARCA4 Proteine) leads to severe proliferation deficits of granule neuron precursors and a hypoplastic cerebellum.

  5. results show that Smarcb1 is required for transcriptional activation of Igfbp7 (zeige IGFBP7 Proteine) and show that re-introduction of Igfbp7 (zeige IGFBP7 Proteine) alone can hinder tumor development; results define a novel mechanism for Smarcb1-mediated tumorigenesis

  6. We find that inactivation of either Brg1 (zeige SMARCA4 Proteine) or Smarcb1 leads to disruptions of specific nucleosome patterning combined with a loss of overall nucleosome occupancy at a large number of promoters, regardless of their association with CpG islands.

  7. SNF5 is a key mediator of Hedgehog (zeige SHH Proteine) signaling and that aberrant activation of GLI1 (zeige GLI1 Proteine) is a previously undescribed targetable mechanism contributing to the growth of malignant rhabdoid tumor cells.

  8. Loss of the SNF5 tumor suppressor leads to elevated expression of the Polycomb (zeige CBX2 Proteine) gene EZH2 (zeige EZH2 Proteine).

  9. SNF5 knockdown inhibits p53 (zeige TP53 Proteine) translation by eIF4E (zeige EIF4E Proteine) and replacement of eIF4E (zeige EIF4E Proteine) in SNF5 knockdown cells restores p53 (zeige TP53 Proteine) expression and cell survival

  10. The loss of this protein, a core subunit of SWI (zeige SMARCA1 Proteine)/SNF (zeige SNRPA Proteine), results in highly penetrant cancer predisposition with 100% of mice developing mature CD8 (zeige CD8A Proteine)(+)T cell lymphoma or rare rhabdoid tumors with a median onset of only 11 weeks.

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Protein Überblick

Protein Überblick

The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SMARCB1

  • matrix metallopeptidase 11 (stromelysin 3) (MMP11)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (Smarcb1)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (smarcb1)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b (smarcb1b)
  • AU020204 Protein
  • Baf47 Protein
  • fc51b01 Protein
  • hSNFS Protein
  • Ini1 Protein
  • MRD15 Protein
  • RDT Protein
  • RTPS1 Protein
  • Sfh1p Protein
  • smarcb1 Protein
  • Snf5 Protein
  • SNF5/INI1 Protein
  • SNF5L1 Protein
  • Snr1 Protein
  • wu:fc51b01 Protein

Bezeichner auf Proteinebene für SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 , matrix metalloproteinase 11 (stromelysin 3) , BAF47 , BRG1-associated factor 47 , SNF5 homolog , hSNF5 , integrase interactor 1 protein , malignant rhabdoid tumor suppressor , sucrose nonfermenting, yeast, homolog-like 1 , mSNF5 , SWI/SNF-related matrix associated protein

GENE ID SPEZIES
769489 Gallus gallus
537412 Bos taurus
6598 Homo sapiens
20587 Mus musculus
443934 Xenopus laevis
486407 Canis lupus familiaris
361825 Rattus norvegicus
30731 Danio rerio
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