SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Proteine (SMARCB1)

The protein encoded by SMARCB1 is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. Zusätzlich bieten wir Ihnen SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Antikörper (134) und SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SMARCB1 6598 Q12824
SMARCB1 20587 Q9Z0H3
Ratte SMARCB1 SMARCB1 361825  
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Showing 7 out of 20 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 7 bis 8 Tage
235,20 €
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HOST_Escherichia coli (E. coli) Human His-SUMO Tag   50 μg Anmelden zum Anzeigen 15 bis 16 Tage
324,76 €
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Hefe Human His tag   50 μg Anmelden zum Anzeigen 12 bis 16 Tage
324,76 €
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HOST_Baculovirus infected Insect Cells Human His tag   20 μg Anmelden zum Anzeigen 6 bis 8 Tage
864,29 €
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SMARCB1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , ,
, , ,
Mouse (Murine)

Weitere Proteine zu SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Interaktionspartnern

Human SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Interaktionspartner

  1. Interactions have been indicated between SMARCB1/INI1 protein and key proteins in various pathways related to tumor proliferation and progression.

  2. The common loss of INI1 expression in rhabdoid and non-rhabdoid tumors will also open new therapeutic doors by developing targeted therapy strategies which may help to consolidate an initial treatment response to conventional radiochemotherapy.

  3. Biallelic alterations in the INI1 gene were identified in 4 of the 5 cases of atypical teratoid/rhabdoid tumors. Three of the 4 cases harbored 2 different mutations, presumably on different alleles (compound heterozygous mutations), and 1 case of which had a splice-site mutation.

  4. The epithelioid variant of schwannoma is rare, and loss of SMARCB1/INI1 expression has been observed in a subset of cases. Our aim was to further define the clinicopathologic features and to evaluate SMARCB1/INI1 deficiency in a large cohort of 65 epithelioid schwannomas diagnosed between 2002 and 2015

  5. SMARCB1 is required for the integrity of SWI (zeige SMARCA1 Proteine)/SNF (zeige SNRPA Proteine) complexes.

  6. INI1 loss occurs rarely in colorectal carcinoma, where it is associated with higher grade, larger tumor size, poorer survival, mismatch repair deficiency, and BRAFV600E mutation.

  7. SWI (zeige SMARCA1 Proteine)/SNF (zeige SNRPA Proteine) complexes lacking SMARCB1 are vital determinants of drug sensitivity, not just to TOP2A (zeige TOP2A Proteine)-targeted agents, but to the much broader range of cancer drugs effluxed by ABCB1 (zeige ABCB1 Proteine).

  8. SMARCB1-deficient sinonasal carcinoma represents an emerging poorly differentiated/undifferentiated sinonasal carcinoma.

  9. Deletions in INI1 gene is associated with Small cell undifferentiated hepatoblastomas.

  10. Our results confirm the pathogenic involvement of SMARCB1/INI1 in childhood chordoma

Mouse (Murine) SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Interaktionspartner

  1. The occurrence of intracranial rhabdoid tumours depends on control of Smarcb1 inactivation.

  2. These results support recent findings regarding the effectivity of EGFR (zeige EGFR Proteine) inhibitors in hindering the proliferation of human MRT cells and demonstrate that activation of EGFR (zeige EGFR Proteine) signaling in Rhabdoid tumors is SMARCB1 dependent.

  3. these findings uncover a novel role for Snf5 in oligodendrocyte generation and survival, and they offer evidence of the first genetically engineered mouse model for AT/RT in the CNS.

  4. This study show here that loss of Smarcb1 and Smarca4 (zeige SMARCA4 Proteine) leads to severe proliferation deficits of granule neuron precursors and a hypoplastic cerebellum.

  5. results show that Smarcb1 is required for transcriptional activation of Igfbp7 (zeige IGFBP7 Proteine) and show that re-introduction of Igfbp7 (zeige IGFBP7 Proteine) alone can hinder tumor development; results define a novel mechanism for Smarcb1-mediated tumorigenesis

  6. We find that inactivation of either Brg1 (zeige SMARCA4 Proteine) or Smarcb1 leads to disruptions of specific nucleosome patterning combined with a loss of overall nucleosome occupancy at a large number of promoters, regardless of their association with CpG islands.

  7. SNF5 is a key mediator of Hedgehog (zeige SHH Proteine) signaling and that aberrant activation of GLI1 (zeige GLI1 Proteine) is a previously undescribed targetable mechanism contributing to the growth of malignant rhabdoid tumor cells.

  8. Loss of the SNF5 tumor suppressor leads to elevated expression of the Polycomb (zeige CBX2 Proteine) gene EZH2 (zeige EZH2 Proteine).

  9. SNF5 knockdown inhibits p53 (zeige TP53 Proteine) translation by eIF4E (zeige EIF4E Proteine) and replacement of eIF4E (zeige EIF4E Proteine) in SNF5 knockdown cells restores p53 (zeige TP53 Proteine) expression and cell survival

  10. The loss of this protein, a core subunit of SWI (zeige SMARCA1 Proteine)/SNF (zeige SNRPA Proteine), results in highly penetrant cancer predisposition with 100% of mice developing mature CD8 (zeige CD8A Proteine)(+)T cell lymphoma or rare rhabdoid tumors with a median onset of only 11 weeks.

SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily B, Member 1 (SMARCB1) Protein Überblick

Protein Überblick

The protein encoded by this gene is part of a complex that relieves repressive chromatin structures, allowing the transcriptional machinery to access its targets more effectively. The encoded nuclear protein may also bind to and enhance the DNA joining activity of HIV-1 integrase. This gene has been found to be a tumor suppressor, and mutations in it have been associated with malignant rhabdoid tumors. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit SMARCB1

  • matrix metallopeptidase 11 (stromelysin 3) (MMP11)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (SMARCB1)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (Smarcb1)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 (smarcb1)
  • SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1b (smarcb1b)
  • AU020204 Protein
  • Baf47 Protein
  • fc51b01 Protein
  • hSNFS Protein
  • Ini1 Protein
  • MRD15 Protein
  • RDT Protein
  • RTPS1 Protein
  • Sfh1p Protein
  • smarcb1 Protein
  • Snf5 Protein
  • SNF5/INI1 Protein
  • SNF5L1 Protein
  • Snr1 Protein
  • wu:fc51b01 Protein

Bezeichner auf Proteinebene für SMARCB1

SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1 , SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1 , matrix metalloproteinase 11 (stromelysin 3) , BAF47 , BRG1-associated factor 47 , SNF5 homolog , hSNF5 , integrase interactor 1 protein , malignant rhabdoid tumor suppressor , sucrose nonfermenting, yeast, homolog-like 1 , mSNF5 , SWI/SNF-related matrix associated protein

GENE ID SPEZIES
769489 Gallus gallus
537412 Bos taurus
6598 Homo sapiens
20587 Mus musculus
443934 Xenopus laevis
486407 Canis lupus familiaris
361825 Rattus norvegicus
30731 Danio rerio
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