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The protein encoded by SMAD5 is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. Zusätzlich bieten wir Ihnen SMAD5 Antikörper (111) und SMAD5 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.
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TGFbeta1a regulates zebrafish posterior lateral line formation via Smad5 mediated pathway.
Alk3 and Alk3b, as well as SMAD5, are essential cellular mediators of BMP signaling in zebrfish.
Data show that interplay of Smad1 (zeige SMAD1 Proteine)/5 and MAP kinase (zeige MAPK1 Proteine) signaling system (ERK (zeige MAPK1 Proteine) signalling) is essential for haemogenic endothelium-based haematopoietic stem cell emergence.
this study uncovers that smad1 (zeige SMAD1 Proteine) and smad9 (zeige SMAD9 Proteine) act redundantly to each other downstream of smad5 to mediate ventral specification and to regulate embryonic myelopoiesis.
Functional investigation of a subset of these genes, fgf10a (zeige FGF10 Proteine), tgfb2 (zeige TGFB2 Proteine), pax9 (zeige PAX9 Proteine), and smad5 revealed their necessity in zebrafish palatogenesis.
maternally supplied Smad5 is already required to mediate ventral specification prior to zygotic Bmp2 (zeige BMP4 Proteine)/7 signaling to establish the initial dorsoventral asymmetry
Data show that patterning of the eye primordia in Smad5-deficient embryos starts during blastula and early gastrula stages.
that specificity of BMP signaling output, with respect to hematopoiesis, can be explained by differential functions of Smad1 (zeige SMAD1 Proteine) and Smad5.
Data show that Smad5 expression is ubiquitous during testis development but becomes cell-specific in the adult.
the BMP-2 (zeige BMP2 Proteine)/Smad1 (zeige GARS Proteine)/5/RUNX2 (zeige RUNX2 Proteine) signaling pathway participates in the silicon-mediated induction of COL-1 and osteocalcin (zeige BGLAP Proteine) synth
miR (zeige MLXIP Proteine)-23a and miR (zeige MLXIP Proteine)-27a target SMAD5 and regulate apoptosis in human granulosa cells via the FasL (zeige FASL Proteine)-Fas (zeige FAS Proteine) pathway
Our findings suggest that suppression of miR (zeige MLXIP Proteine)-222-3p activity promoted osteogenic differentiation hBMSCs through regulating Smad5-RUNX2 (zeige RUNX2 Proteine) signaling axis.
Overexpression of the BMP4 (zeige BMP4 Proteine)/SMAD4 (zeige SMAD4 Proteine)/SMAD5 signaling pathway could predict poor clinical outcome in skull base chordomas, suggesting activation of this pathway is involved in chordoma pathogenesis.
The polycomb group protein L3MBTL1 (zeige L3MBTL1 Proteine) represses a SMAD5-mediated hematopoietic transcriptional program in human pluripotent stem cells.
adult human Sertoli cells assumed similar morphological features, stable global gene expression profiles and numerous proteins, and activation of AKT (zeige AKT1 Proteine) and SMAD1 (zeige GARS Proteine)/5 during long-period culture.
balance between Smad1 (zeige GARS Proteine)/5- and Smad2 (zeige SMAD2 Proteine)/3-dependent signaling defines the outcome of the effect of TGF-beta (zeige TGFB1 Proteine) on atherosclerosis where Smad1 (zeige GARS Proteine)/5 is responsible for proatherogenic effects
among the 15 SNPs, rs3206634 was significantly associated with KD in a recessive model (odds ratio = 2.31, p = 0.019), whereas there was no association between any of the 15 SNPs and CALs (zeige CA8 Proteine).
Our results indicated that KGN promoted the type-I collagen synthesis of dermal fibroblasts in vitro and in the dermis of mice through activation of the smad4 (zeige SMAD4 Proteine)/smad5 pathway.
Inhibiting Smurf1 (zeige SMURF1 Proteine) mediated ubiquitination of Smad1 (zeige GARS Proteine)/5.
We discovered that Smad1 (zeige SMAD1 Proteine)/5/4-Amhr2 (zeige AMHR2 Proteine)-cre KO females have malformed oviducts that subsequently develop oviductal diverticuli. In addition, uteri from Smad1 (zeige SMAD1 Proteine)/5/4-Amhr2 (zeige AMHR2 Proteine)-cre KO females exhibit multiple defects in stroma, epithelium, and smooth muscle layers and fail to assemble a closed uterine lumen upon embryo implantation, with defective uterine decidualization that led to pregnancy loss at early to mid-gestation.
these studies characterize an accessory TGF-beta (zeige TGFB1 Proteine)-stimulated BMP R-Smad (zeige SMAD1 Proteine) signaling mechanism in interstitial cells of the developing lung.
Thyroid-specific Smad1 (zeige SMAD1 Proteine) and Smad5 double-knockout (Smad1 (zeige SMAD1 Proteine)/5(dKO)) mice displayed growth retardation, hypothyroidism and defective follicular architecture.
Smad1 (zeige SMAD1 Proteine) and Smad5 have overlapping functions to govern hepcidin (zeige HAMP Proteine) transcription. Moreover, erythropoietin (zeige EPO Proteine) and erythroferrone target Smad1 (zeige SMAD1 Proteine)/5 signaling and require Smad1 (zeige SMAD1 Proteine)/5 to suppress hepcidin (zeige HAMP Proteine) expression.
miR (zeige MLXIP Proteine)-106b-5p and miR-17-5p are novel Smad5 regulators.
BetA can enhance in vivo osteogenic potentials of BMP2 (zeige BMP2 Proteine), possibly via stimulating Smad 1 (zeige SMAD1 Proteine)/5/8 and p38 (zeige CRK Proteine) pathways, and combination of both agents can be considered as a therapeutic strategy for bone diseases.
Data show that in R-Smad (zeige SMAD1 Proteine) proteins Smad1 (zeige SMAD1 Proteine);Smad5 knockout embryonic stem cells (mESCs), the bone morphogenetic proteins (BMP)-SMAD (zeige SMAD1 Proteine) signaling is dispensable for self-renewal.
Data show that R-Smad Proteins SMAD1 and SMAD5, which transduce bone morphogenetic protein (BMP) signals, recognize enhancer regions together with Kruppel-like factors KLF4 and KLF5 in naive embryonic stem cell (mESCs).
The crystal structure of Smad5-MH1 (zeige SCN5A Proteine) domain in complex with a composite DNA sequence demonstrates that the MH1 (zeige SCN5A Proteine) domain is targeted to a binding site with modular binding modes, and the length of the DNA spacer affects the MH1 (zeige SCN5A Proteine) assembly.
The findings demonstrate for the first time that KMUP-1 can promote osteoblast maturation and differentiation in vitro via BMP-2 (zeige BMP2 Proteine)/Smad1 (zeige SMAD1 Proteine)/5/8 and Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathways.
a detailed computational model for TGF-beta (zeige TGFB1 Proteine) signalling that incorporates elements of previous models together with crosstalking between Smad1 (zeige SMAD1 Proteine)/5/8 and Smad2 (zeige SMAD2 Proteine)/3 channels through a negative feedback loop dependent on Smad7 (zeige SMAD7 Proteine).
The protein encoded by this gene is involved in the TGF-beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by BMP type 1 receptor kinase. Three transcript variants encoding the same protein have been found for this gene.
mothers against decapentaplegic homolog 5
, SMA- and MAD-related protein 5
, SMAD 5
, SMAD family member 5
, mothers against DPP homolog 5
, MAD, mothers against decapentaplegic homolog 5
, SMAD, mothers against DPP homolog 5
, mothers against decapentaplegic, drosophila, homolog of, 5
, MAD homolog 5
, Smad 5
, Mothers against decapentaplegic homolog 5