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This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. Zusätzlich bieten wir Ihnen SRGAP2 Proteine (3) und SRGAP2 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SRGAP2 Primary Antibody für ELISA, ICC - ABIN4355968
Jin, Smith, Stark, Wells, Fawcett, Kulkarni, Metalnikov, ODonnell, Taylor, Taylor, Zougman, Woodgett, Langeberg, Scott, Pawson: Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. in Current biology : CB 2004
The extended F-BAR (F-BARx) domain of SRGAP2 (zeige SRGAP3 Antikörper) generates membrane protrusions when expressed in COS-7 cells, while most F-BARs induce the opposite effect: membrane invaginations. As a first step to understand this discrepancy, the F-BARx domain of SRGAP2 (zeige SRGAP3 Antikörper) was isolated and crystallized after co-expression with the carboxy domains of the protein. Diffraction data were reprocessed with a high-resolution cutoff of 2.2 A.
human-specific duplication of SRGAP2 (zeige SRGAP3 Antikörper) might have contributed to the emergence of unique traits of human neurons while preserving the excitation/inhibition balance
This study illustrated that the role of SRGAP2 (zeige SRGAP3 Antikörper) protein and its human-specific paralogs in human brain development and evolution.
interlocus gene conversions in SRGAP2 (zeige SRGAP3 Antikörper)
SRGAP2 (zeige SRGAP3 Antikörper) has been highly conserved over mammalian evolution, and human is the only lineage wherein gene duplications have occurred. Our analysis indicates that the duplications spread across 80 Mbp (zeige MBL2 Antikörper) of chromosome 1 at a time corresponding to the transition from Australopithecus to Homo.
Results uncover a new function for ancestral SRGAP2 (zeige SRGAP3 Antikörper) in promoting dendritic spine maturation and indicate that expression of a human-specific paralog of SRGAP2 (zeige SRGAP3 Antikörper) in mouse pyramidal neurons extends the phase of spine development and leads to an increased density of longer spines in vivo, a feature characterizing pyramidal neurons in the human neocortex
after Rac-dependent activation of FMNL1, srGAP2 mediates a potent mechanism to limit the duration of Rac action and inhibit formin activity during rapid actin dynamics.
srGAP2 (zeige SRGAP3 Antikörper) arginine methylation plays important roles in cell spreading and cell migration through influencing membrane protrusion.
FNBP2 gene was linked to IKBKE (zeige IKBKE Antikörper) and NORE1 (zeige RASSF5 Antikörper) genes on human chromosome 1q32.1. FNBP2 mRNA was expressed in melanoma, germ cell tumors, chondrosarcoma and retinoblastoma.
The inverse F-BAR domain protein srGAP2 (zeige SRGAP3 Antikörper) acts through srGAP3 (zeige SRGAP3 Antikörper) to modulate neuronal differentiation and neurite outgrowth of mouse neuroblastoma (zeige ARHGEF16 Antikörper) cells.
Data show that srGAP2 (zeige SRGAP3 Antikörper) is expressed in zones of neuronal differentiation in many different tissues of the central nervous system.
Study reports that srGAP2 (zeige SRGAP3 Antikörper) negatively regulates neuronal migration and induces neurite outgrowth and branching through the ability of its F-BAR domain to induce filopodia-like membrane protrusions resembling those induced by I-BAR domains.
This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogous loci on human chromosome 1, resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus.
SLIT-ROBO Rho GTPase-activating protein 2
, formin binding protein 2
, formin-binding protein 2
, rho GTPase-activating protein 34
, formin-binding protein 27