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Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. Zusätzlich bieten wir Ihnen ROBO4 Kits (8) und ROBO4 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal ROBO4 Primary Antibody für FACS, WB - ABIN4900077
Zhang, Prahst, Mathivet, Pibouin-Fragner, Zhang, Genet, Tong, Dubrac, Eichmann: The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. in Nature communications 2016
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Human Monoclonal ROBO4 Primary Antibody für CyTOF, FACS - ABIN4900078
Guijarro-Muñoz, Cuesta, Alvarez-Cienfuegos, Geng, Alvarez-Vallina, Sanz: The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. in Experimental cell research 2012
Show all 2 Pubmed References
Human Monoclonal ROBO4 Primary Antibody für FACS - ABIN4897148
Zhang, Fisher, Newey, Smythe, Tatton, Tsaknakis, Forde, Carpenter, Athanassopoulos, Hale, Ferguson, Tyler, Watt: The impact of proliferative potential of umbilical cord-derived endothelial progenitor cells and hypoxia on vascular tubule formation in vitro. in Stem cells and development 2009
Results show that hyperglycemia-induced upregulation of Robo4 in retinal endothelial cells is directly mediated by transcription factor SP1 (zeige SP1 Antikörper) which increases the transcription of Robo4 via an additional binding site in Robo4 promoter. SP1 (zeige PSG1 Antikörper)/Robo4 can regulate the migration, monolayer permeability and angiogenesis of retinal endothelial cells under hyperglycemic conditions.
there was a increase in Robo4 expression under hyperglycemic conditions, while there was a decrease under hypoxic and combined hypoxic and hyperglycemic conditions, suggesting Robo4 might play different roles in various stages of diabetic retinopathy
These results suggest that Slit2 (zeige SLIT3 Antikörper)/Robo1 (zeige ROBO1 Antikörper) binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 (zeige ROBO1 Antikörper) may function by interacting with CdGAP (zeige ARHGAP31 Antikörper) in HUVECs.
results indicate that AP-1 (zeige FOSB Antikörper) complexes regulate Robo4 gene expression in endothelial cells
BM Robo4 expression can serve as a new biomarker to predict clinical outcomes in AML (zeige RUNX1 Antikörper) patients and Robo4 may serve as a potential therapeutic target in patients with higher Robo4 expression.
Robo4 suppressed glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated activation of PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) and FAK (zeige PTK2 Antikörper) signaling pathways.
Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha (zeige HIF1A Antikörper) suggesting that Robo4 is positively regulated by HIF-1alpha (zeige HIF1A Antikörper) under normoxic and hypoxic conditions in microvascular endothelial cells in vitro.
Plasma Robo4 levels are increased, transiently, following cardiac surgery requiring CPB (zeige CPB1 Antikörper)
This study demonistrated that roundabout (zeige ROBO1 Antikörper) 4 regulates blood-tumor barrier permeability through the modulation of ZO-1 (zeige TJP1 Antikörper), Occludin (zeige OCLN Antikörper), and Claudin-5 (zeige CLDN5 Antikörper) expression.
Endothelial cell-specific DNA methylation (zeige HELLS Antikörper) pattern of the Robo4 proximal promoter is determined during cell differentiation and contributes to regulation of EC-specific Robo4 gene expression.
endothelial Robo4 signaling is important for suppressing breast cancer growth and metastasis, and it can be targeted (enhanced) by administrating a small molecular drug.
Robo4 vaccines induce antibodies that retard tumor growth.
Robo4 and Src family kinases are involved in the mechanisms of embryonic vascular defects caused by the Hrt/Hey deficiency.
These results clearly indicate that Robo4 plays a role in hematopoietic stem cells trafficking such as bone marrow homing and peripheral mobilization.
our results showed an important role of Robo4 in the regulation of cortical radial migration through Slit-dependent and -independent mechanisms
Data found that expression of Slit2 (zeige SLIT2 Antikörper) and SDF1 (zeige CXCL12 Antikörper) were dynamically regulated in mesenchymal stem cells and OBC-like populations following radiation, while Robo4 expression was restricted to endothelial cells.
augmenting the host Robo4/Slit2 system could provide a useful therapeutic approach to control pathological angiogenesis associated with HSV induced stromal keratitis
Robo4 specifically binds to UNC5B (zeige UNC5B Antikörper), a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.
Activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm.
enhanced growth of blood vessels in Robo4(-/-) endothelium is due to activation of vascular endothelial growth factor (VEGF)-R2 signaling through the Src and FAK kinases.
Sox7 (zeige SOX7 Antikörper) and Sox18 (zeige SOX18 Antikörper)-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature
robo4 is essential for coordinated symmetric and directed sprouting of intersomitic vessels.
Robo4 mediates attraction-signaling mechanisms through Rho GTPases in vertebrate vascular guidance
Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).
roundabout homolog 4
, roundabout homolog 4, magic roundabout
, Magic roundabout
, magic roundabout