anti-Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) Antikörper

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. Zusätzlich bieten wir Ihnen ROBO4 Kits (8) und ROBO4 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ROBO4 74144 Q8C310
ROBO4 54538 Q8WZ75
ROBO4 300518 Q80W87
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Showing 10 out of 129 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus PE FACS Detection of ROBO4 in Human ROBO4 Transfectants by Flow Cytometry. Human ROBO4 transfectants were stained with Mouse Anti-Human ROBO4 PE-conjugated Monoclonal Antibody. Detection of ROBO4 in Human ROBO4 Transfectants by Flow Cytometry. Human ROBO4 transfectants were stained with Mouse Anti-Human ROBO4 PE-conjugated Monoclonal Antibody. 100 Tests Anmelden zum Anzeigen 3 bis 4 Tage
305,00 €
Details
Human Maus Unkonjugiert FACS, WB Detection of ROBO4 in HUVEC Human Cells by Flow Cytometry. Human umbilical vein endothelial cells were stained with Mouse Anti-Human ROBO4 Monoclonal Antibody. Detection of ROBO4 in HUVEC Human Cells by Flow Cytometry. Human umbilical vein endothelial cells were stained with Mouse Anti-Human ROBO4 Monoclonal Antibody. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
250,00 €
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Mouse intestine cells probed with Rabbit Anti-Robo4 Polyclonal Antibody, FITC Conjugated (ABIN714866-FITC) (green) at 1:50 for 60 minutes compared to control cells (red). Rat brain lysate probed with Anti Robo4 Polyclonal Antibody, Unconjugated  at 1:3000 for 90 min at 37˚C. Predicted band 108kD. Observed band size: 171kD 100 μL Anmelden zum Anzeigen 9 bis 12 Tage
304,36 €
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Human Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
360,85 €
Details
Human Ziege Biotin FACS, WB   50 μg Anmelden zum Anzeigen 3 bis 4 Tage
380,00 €
Details
Human Kaninchen Unkonjugiert ELISA   100 μg Anmelden zum Anzeigen 18 bis 20 Tage
250,00 €
Details
Human Kaninchen Unkonjugiert IHC (p), IHC, WB Detection of ROBO4 in HUVEC lysate using ABIN189711. Detection of ROBO4 in human placental epithelial cells and trophoblasts using ABIN189711. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
291,00 €
Details
Human Kaninchen Unkonjugiert IHC (p), IHC, WB Detection of ROBO4 in HUVEC lysate using ABIN189709. Detection of ROBO4 in endothelium and trophoblasts of the placenta using ABIN189709. 0.1 mL Anmelden zum Anzeigen 2 bis 4 Tage
291,00 €
Details
Human Kaninchen Alexa Fluor 594 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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Human Kaninchen Alexa Fluor 350 IF (p)   100 μL Anmelden zum Anzeigen 18 bis 22 Tage
414,64 €
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ROBO4 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-ROBO4 Antikörper

  1. Human Polyclonal ROBO4 Primary Antibody für ELISA - ABIN1999429 : Huminiecki, Gorn, Suchting, Poulsom, Bicknell: Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. in Genomics 2002 (PubMed)
    Zeige alle 2 Referenzen für 1999429

  2. Human Polyclonal ROBO4 Primary Antibody für FACS, WB - ABIN4900077 : Zhang, Prahst, Mathivet, Pibouin-Fragner, Zhang, Genet, Tong, Dubrac, Eichmann: The Robo4 cytoplasmic domain is dispensable for vascular permeability and neovascularization. in Nature communications 2016 (PubMed)
    Zeige alle 2 Referenzen für 4900077

  3. Human Monoclonal ROBO4 Primary Antibody für FACS - ABIN4897148 : Zhang, Fisher, Newey, Smythe, Tatton, Tsaknakis, Forde, Carpenter, Athanassopoulos, Hale, Ferguson, Tyler, Watt: The impact of proliferative potential of umbilical cord-derived endothelial progenitor cells and hypoxia on vascular tubule formation in vitro. in Stem cells and development 2009 (PubMed)

  4. Human Monoclonal ROBO4 Primary Antibody für FACS, WB - ABIN4900079 : Guijarro-Muñoz, Cuesta, Alvarez-Cienfuegos, Geng, Alvarez-Vallina, Sanz: The axonal repellent Slit2 inhibits pericyte migration: potential implications in angiogenesis. in Experimental cell research 2012 (PubMed)

Weitere Antikörper gegen ROBO4 Interaktionspartner

Zebrafish Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) Interaktionspartner

  1. Sox7 (zeige SOX7 Antikörper) and Sox18 (zeige SOX18 Antikörper)-mediated transcriptional regulation of Robo4 is important in the developing embryonic vasculature

  2. robo4 is essential for coordinated symmetric and directed sprouting of intersomitic vessels.

  3. Robo4 mediates attraction-signaling mechanisms through Rho GTPases in vertebrate vascular guidance

Mouse (Murine) Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) Interaktionspartner

  1. endothelial Robo4 signaling is important for suppressing breast cancer growth and metastasis, and it can be targeted (enhanced) by administrating a small molecular drug.

  2. Robo4 vaccines induce antibodies that retard tumor growth.

  3. Robo4 and Src family kinases are involved in the mechanisms of embryonic vascular defects caused by the Hrt/Hey deficiency.

  4. These results clearly indicate that Robo4 plays a role in hematopoietic stem cells trafficking such as bone marrow homing and peripheral mobilization.

  5. our results showed an important role of Robo4 in the regulation of cortical radial migration through Slit-dependent and -independent mechanisms

  6. Data found that expression of Slit2 (zeige SLIT2 Antikörper) and SDF1 (zeige CXCL12 Antikörper) were dynamically regulated in mesenchymal stem cells and OBC-like populations following radiation, while Robo4 expression was restricted to endothelial cells.

  7. augmenting the host Robo4/Slit2 system could provide a useful therapeutic approach to control pathological angiogenesis associated with HSV induced stromal keratitis

  8. Robo4 specifically binds to UNC5B (zeige UNC5B Antikörper), a vascular Netrin receptor, revealing unexpected interactions between two endothelial guidance receptors.

  9. Activating with the soluble ligand Slit an endothelium-specific, Robo4-dependent signaling pathway that strengthens the vascular barrier, diminishing deleterious aspects of the host's response to the pathogen-induced cytokine storm.

  10. enhanced growth of blood vessels in Robo4(-/-) endothelium is due to activation of vascular endothelial growth factor (VEGF)-R2 signaling through the Src and FAK kinases.

Human Roundabout, Axon Guidance Receptor, Homolog 4 (Drosophila) (ROBO4) Interaktionspartner

  1. Results show that hyperglycemia-induced upregulation of Robo4 in retinal endothelial cells is directly mediated by transcription factor SP1 (zeige SP1 Antikörper) which increases the transcription of Robo4 via an additional binding site in Robo4 promoter. SP1 (zeige PSG1 Antikörper)/Robo4 can regulate the migration, monolayer permeability and angiogenesis of retinal endothelial cells under hyperglycemic conditions.

  2. there was a increase in Robo4 expression under hyperglycemic conditions, while there was a decrease under hypoxic and combined hypoxic and hyperglycemic conditions, suggesting Robo4 might play different roles in various stages of diabetic retinopathy

  3. These results suggest that Slit2 (zeige SLIT3 Antikörper)/Robo1 (zeige ROBO1 Antikörper) binding exerts an effect on cell migration, which is negatively regulated by Robo4, and Robo1 (zeige ROBO1 Antikörper) may function by interacting with CdGAP (zeige ARHGAP31 Antikörper) in HUVECs.

  4. results indicate that AP-1 (zeige FOSB Antikörper) complexes regulate Robo4 gene expression in endothelial cells

  5. BM Robo4 expression can serve as a new biomarker to predict clinical outcomes in AML (zeige RUNX1 Antikörper) patients and Robo4 may serve as a potential therapeutic target in patients with higher Robo4 expression.

  6. Robo4 suppressed glioma-induced endothelial cell proliferation, migration and tube formation in vitro by inhibiting VEGR2-mediated activation of PI3K (zeige PIK3CA Antikörper)/AKT (zeige AKT1 Antikörper) and FAK (zeige PTK2 Antikörper) signaling pathways.

  7. Increased or decreased expression of Robo4 by stimulation or knockdown of HIF-1alpha (zeige HIF1A Antikörper) suggesting that Robo4 is positively regulated by HIF-1alpha (zeige HIF1A Antikörper) under normoxic and hypoxic conditions in microvascular endothelial cells in vitro.

  8. Plasma Robo4 levels are increased, transiently, following cardiac surgery requiring CPB (zeige CPB1 Antikörper)

  9. This study demonistrated that roundabout (zeige ROBO1 Antikörper) 4 regulates blood-tumor barrier permeability through the modulation of ZO-1 (zeige TJP1 Antikörper), Occludin (zeige OCLN Antikörper), and Claudin-5 (zeige CLDN5 Antikörper) expression.

  10. Endothelial cell-specific DNA methylation (zeige HELLS Antikörper) pattern of the Robo4 proximal promoter is determined during cell differentiation and contributes to regulation of EC-specific Robo4 gene expression.

ROBO4 Antigen-Profil

Protein Überblick

Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins (By similarity).

Genbezeichner und Symbole assoziert mit ROBO4

  • roundabout homolog 4 (robo4) Antikörper
  • roundabout homolog 4 (Drosophila) (Robo4) Antikörper
  • roundabout homolog 4, magic roundabout (Drosophila) (ROBO4) Antikörper
  • roundabout, axon guidance receptor, homolog 4 (Drosophila) (ROBO4) Antikörper
  • roundabout, axon guidance receptor, homolog 4 (Drosophila) (Robo4) Antikörper
  • 1200012D01Rik Antikörper
  • AI593217 Antikörper
  • ECSM4 Antikörper
  • MRB Antikörper
  • sc:d0823 Antikörper
  • wu:fa16f09 Antikörper

Bezeichner auf Proteinebene für ROBO4

roundabout homolog 4 , magic roundabout , Magic roundabout , roundabout homolog 4, magic roundabout

GENE ID SPEZIES
259253 Danio rerio
560765 Danio rerio
74144 Mus musculus
783785 Bos taurus
54538 Homo sapiens
489306 Canis lupus familiaris
100524821 Sus scrofa
300518 Rattus norvegicus
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