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The protein encoded by RNF139 is a multi-membrane spanning protein containing a RING-H2 finger. Zusätzlich bieten wir Ihnen Ring Finger Protein 139 Proteine (4) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 57 products:
Human Polyclonal RNF139 Primary Antibody für ELISA, WB - ABIN564886
Brauweiler, Lorick, Lee, Tsai, Chan, Weissman, Drabkin, Gemmill: RING-dependent tumor suppression and G2/M arrest induced by the TRC8 hereditary kidney cancer gene. in Oncogene 2007
Show all 4 Pubmed References
Human Monoclonal RNF139 Primary Antibody für IHC (p), ELISA - ABIN564887
Adams, Simms, Abdelhamed, Dawe, Szymanska, Logan, Wheway, Pitt, Gull, Knowles, Blair, Cross, Sayer, Johnson: A meckelin-filamin A interaction mediates ciliogenesis. in Human molecular genetics 2012
interaction with Bag1 (zeige BAG1 Antikörper) then shifts hERG (zeige KCNH2 Antikörper) degradation to the membrane-anchored E3 ligase TRC8 and its E2-conjugating enzyme Ube2g2 (zeige UBE2G2 Antikörper), as determined by siRNA screening
TRC8 and TMEM129 are endoplasmic reticulum-associated degradation ubiquitin E3 ligases for viral and cellular targeting of MHC class I. (Review)
TRC8 suppresses tumorigenesis through targeting heme oxygenase-1 (zeige HMOX1 Antikörper) for ubiquitination and degradation.
TRC8 function may provide a regulatory link between the lipid and protein biosynthetic pathways.
TRC8 modulation of sterol response element binding protein activity comprises a novel regulatory link between growth control and the cholesterol/lipid homeostasis pathway.
The presence of diploid and tetraploid tumor cells with and without TRC8 deletions on the nontranslocated chromosome suggest that loss of the remaining normal allele of TRC8 may contribute to tumor development at later stages.
TRC8 is a novel sterol-sensing endoplasmic reticulum membrane protein (zeige SLC39A6 Antikörper) that hinders SREBP-2 (zeige SREBF2 Antikörper) processing through interaction with SREBP-2 (zeige SREBF2 Antikörper) and SCAP (zeige SH2D2A Antikörper), regulating its own turnover rate by means of its E3 ubiquitin ligase (zeige MUL1 Antikörper) activity
Data show that the TRC8 E3 ligase is required for MHC I dislocation from the ER and identify a new complex associated with mammalian ERAD.
The protein encoded by this gene is a multi-membrane spanning protein containing a RING-H2 finger. This protein is located in the endoplasmic reticulum, and has been shown to possess ubiquitin ligase activity. This gene was found to be interrupted by a t(3:8) translocation in a family with hereditary renal and non-medulary thyroid cancer. Studies of the Drosophila counterpart suggested that this protein may interact with tumor suppressor protein VHL, as well as with COPS5/JAB1, a protein responsible for the degradation of tumor suppressor CDKN1B/P27KIP.
E3 ubiquitin-protein ligase RNF139
, multiple membrane spanning receptor TRC8
, patched related protein translocated in renal cancer
, translocation in renal carcinoma on chromosome 8 protein
, RING finger protein 139
, ring finger protein 139 S homeolog