anti-Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) Antikörper

RPE65 encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. Zusätzlich bieten wir Ihnen RPE65 Kits (11) und RPE65 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
RPE65 6121 Q16518
RPE65 19892  
RPE65 89826  
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Top anti-RPE65 Antikörper auf antikoerper-online.de

Showing 10 out of 65 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Huhn Maus Unkonjugiert CyTOF, FACS, ICC, IF, IHC, IHC (fro), IHC (p), WB RPE65 detected in bovine and human samples. Lane 1: bovine RPE membrane, lane 2: recombinant human RPE transfected COS7 cell lysate. Immunohistochemical staining of RPE65 in mouse retina tissue using ABIN151819. 0.2 mL Anmelden zum Anzeigen 7 bis 9 Tage
$473.81
Details
Ratte Ziege Unkonjugiert ELISA, WB ABIN238680 (0.5µg/ml) staining of Rat Retina lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$326.89
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Huhn Maus Biotin ICC, IF, IHC (fro), IHC (p), WB   0.2 mL Anmelden zum Anzeigen 7 bis 9 Tage
$538.13
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Rind (Kuh) Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$610.50
Details
Huhn Maus Alexa Fluor 647 FACS, ICC, IF, IHC (fro), IHC (p), WB   0.2 mL Anmelden zum Anzeigen 7 bis 9 Tage
$500.06
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Hund Ziege Unkonjugiert WB   0.1 mg Anmelden zum Anzeigen 10 bis 12 Tage
$375.38
Details
Huhn Maus HRP IHC (fro), IHC (p), WB   0.2 mL Anmelden zum Anzeigen 7 bis 9 Tage
$538.13
Details
Ratte Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using RPE65 antibody. 100 μL Anmelden zum Anzeigen 16 Days
$323.13
Details
Rind (Kuh) Maus Unkonjugiert ICC, IHC (fro), IF, ELISA, WB   100 μL Anmelden zum Anzeigen 7 bis 9 Tage
$881.83
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RPE65 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-RPE65 Antikörper

  1. Chicken Monoclonal RPE65 Primary Antibody für CyTOF, FACS - ABIN151819 : Jacobson, Aleman, Cideciyan, Heon, Golczak, Beltran, Sumaroka, Schwartz, Roman, Windsor, Wilson, Aguirre, Stone, Palczewski: Human cone photoreceptor dependence on RPE65 isomerase. in Proceedings of the National Academy of Sciences of the United States of America 2007 (PubMed)
    Show all 45 Pubmed References

  2. Chicken Monoclonal RPE65 Primary Antibody für IHC (fro), IHC (p) - ABIN314162 : Jiang, Ke, Sun, Han, Kaplan, Shao: Reactivation of uveitogenic T cells by retinal astrocytes derived from experimental autoimmune uveitis-prone B10RIII mice. in Investigative ophthalmology & visual science 2008 (PubMed)
    Show all 10 Pubmed References

  3. Chicken Monoclonal RPE65 Primary Antibody für ICC, IF - ABIN314161 : Lall, Ferrell, Nagar, Fleisher, McGahan: Iron regulates L-cystine uptake and glutathione levels in lens epithelial and retinal pigment epithelial cells by its effect on cytosolic aconitase. in Investigative ophthalmology & visual science 2008 (PubMed)
    Show all 10 Pubmed References

  4. Chicken Monoclonal RPE65 Primary Antibody für FACS, ICC - ABIN4889975 : Lyzogubov, Bora, Wu, Horn, de Roque, Rudolf, Atkinson, Bora: The Complement Regulatory Protein CD46 Deficient Mouse Spontaneously Develops Dry-Type Age-Related Macular Degeneration-Like Phenotype. in The American journal of pathology 2016 (PubMed)

  5. Rat (Rattus) Polyclonal RPE65 Primary Antibody für ELISA, WB - ABIN4351025 : Rolling, Le Meur, Stieger, Smith, Weber, Deschamps, Nivard, Mendes-Madeira, Provost, Péréon, Cherel, Ali, Hamel, Moullier, Rolling et al.: Gene therapeutic prospects in early onset of severe retinal dystrophy: restoration of vision in RPE65 Briard dogs using an AAV serotype 4 vector that specifically targets the retinal pigmented ... in Bulletin et mémoires de l'Académie royale de médecine de Belgique 2007 (PubMed)

Weitere Antikörper gegen RPE65 Interaktionspartner

Human Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) Interaktionspartner

  1. By using whole-exome sequencing analysis, three RPE65 mutations were identified in two Japanese patients with leber congenital amaurosis (LCA (zeige CLTA Antikörper)). This approach would be useful for identification of disease-causing mutations of LCA (zeige CLTA Antikörper).

  2. RPE65 variants are the most prevalent causes of Leber congenital amaurosis in Denmark.

  3. Hypomorphic mutations of RPE65 are associated with mild disease in childhood with preservation of good visual acuity into adulthood; they may in rare cases be associated with a flecked retina appearance similar to fundus albipunctatus.

  4. Influx of T lymphocytes was associated with retinal pigment epithelium and choroidal thinning and diminished expression of RPE65 mRNA, an essential enzyme of the visual cycle.

  5. These data also help define minimal requirements of chromophore for photoreceptor survival in vivo and may be useful in assessing a beneficial therapeutic dose for RPE65 gene therapy in humans.

  6. three Leber congenital amaurosis -associated RPE65 mutants (R91W, Y249C and R515W) undergo rapid proteasomal degradation mediated by the 26 S proteasome non-ATPase (zeige DNAH8 Antikörper) regulatory subunit 13.

  7. Studies indicate that patients with retinol isomerase RPE65R91W mutation have useful cone-mediated vision in the first decade of life, suggesting partial activity of the mutant RPE65R91W protein.

  8. Data show that 4-phenylbutyrate (PBA) displayed a significant synergistic effect on the low temperature-mediated rescue of the mutant isomerase activity of RPE65.

  9. Expressions of MDSC, FOXP3 (zeige FOXP3 Antikörper)+TILs, and CTLA-4 (zeige CTLA4 Antikörper) are relative stable after nCRT

  10. We showed that miR (zeige MLXIP Antikörper)-410 directly regulates predicted target genes OTX2 (zeige OTX2 Antikörper) and RPE65.

Mouse (Murine) Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) Interaktionspartner

  1. these observations suggest that D477G acts as a dominant-negative mutant of RPE65 that delays chromophore regeneration.

  2. The Leu450Met variant of RPE65 is expressed in C57BL/6 and in many genetically modified mice. It confers significant resistance to light induced retinal degeneration (LIRD).

  3. Influx of T lymphocytes was associated with retinal pigment epithelium and choroidal thinning and diminished expression of RPE65 mRNA, an essential enzyme of the visual cycle.

  4. the RPE65 protein expression was abnormal

  5. These data also help define minimal requirements of chromophore for photoreceptor survival in vivo and may be useful in assessing a beneficial therapeutic dose for RPE65 gene therapy in humans.

  6. properties of disease causing RPE65 with regard to molecular pathogenic mechanism

  7. The rd12 lesion is in Rpe65. The rd12 mutant phenotype inherits in a semidominant manner. The effects of the mutant mRNA on visual function may result from inefficient binding to ribosomes for translation.

  8. Despite the previously reported upregulation of Cspg5 (zeige CSPG5 Antikörper) during retinal degeneration in Rpe65/ mice, no protective effect or any involvement of Cspg5 (zeige CSPG5 Antikörper) in disease progression was identified.

  9. To recapitulate this event in vivo, we examined tumor formation in NOG (zeige NOG Antikörper) mice after subcutaneous injection of iPSCs with or without an iPSC-derived RPE (zeige RPE Antikörper) sheet (2.5 x 10(5) RPE (zeige RPE Antikörper) cells).

  10. Cone-opsin (zeige RHO Antikörper) trafficking defects were replicated in Rpe65-/- Rho-/- retina-retinal pigment epithelium cultures.

Fruit Fly (Drosophila melanogaster) Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) Interaktionspartner

  1. study identifies NinaB as a key component for visual pigment production and provides evidence that chromophore in opsin (zeige RHO Antikörper)-deficient photoreceptors can elicit retinal degeneration

  2. Data show that carotenoid-isomerooxygenase activity of NinaB is more generally found in insects, and provide physiological evidence that carotenoids such as 11-cis (zeige CISH Antikörper)-retinal can promote visual pigment biogenesis in the dark.

Cow (Bovine) Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) Interaktionspartner

  1. Data indicate that Structural differences between delipidated and nondelipidated RPE65 uncovered key residues involved in substrate uptake and processing.

  2. oxidative stress during the visual cycle results in cleavage of RPE65

  3. the enzymatic activity of native RPE65 strongly depends on its membrane binding and phospholipid environment

  4. Rpe65 isomerase associates with membranes through an electrostatic interaction with acidic phospholipid headgroups.

  5. retinoid binding role for RPE65

  6. Quenching of protein fluorescence is used to demonstrate quantitatively that RPE65 functions by binding to and mobilizing the highly hydrophobic all-trans-retinyl esters, allowing them to enter the visual cycle.

  7. Rpe65 converts an all-trans-retinyl ester to 11-cis (zeige CISH Antikörper)-retinol and has been identified as retinoid isomerase. Mutations in RPE65 are associated with Leber hereditary optic atrophy

  8. Data show that RPE65 is a moderately specific retinoid binding protein directed at long chain all-trans-retinyl esters.

  9. investigation of metal ions required for the isomerohydrolase activity of RPE65 using the conversion of all-trans-[3H]retinol to 11-cis (zeige CISH Antikörper)-[3H]retinol as the measure for isomerohydrolase activity

  10. LRAT (zeige LRAT Antikörper) is not required for isomerase activity beyond synthesis of retinyl-ester substrate, and the association of Rpe65 with membranes is neither dependent upon LRAT (zeige LRAT Antikörper) nor the result of S-palmitoylation

Zebrafish Retinal Pigment Epithelium-Specific Protein 65kDa (RPE65) Interaktionspartner

RPE65 Antigen-Profil

Protein Überblick

This gene encodes a protein which is located in the retinal pigment epithelium and is involved in the production of 11-cis retinal and in visual pigment regeneration. There are two forms of this protein, a soluble form called sRPE65, and a palmitoylated, membrane-bound form known as mRPE65. mRPE65 serves as the palmitoyl donor for lecithin retinol acyl transferase (LRAT), the enzyme that catalyzes the vitamin A to all trans retinol step of the chromophore regeneration process. Both mRPE65 and sRPE65 also serve as regulatory proteins, with the ratio and concentrations of these molecules playing a role in the inhibition of 11-cis retinal synthesis. Mutations in this gene have been associated with Leber congenital amaurosis type 2 (LCA2) and retinitis pigmentosa.

Genbezeichner und Symbole assoziert mit RPE65

  • RPE65, retinoid isomerohydrolase (RPE65) Antikörper
  • retinal pigment epithelium 65 (Rpe65) Antikörper
  • neither inactivation nor afterpotential B (ninaB) Antikörper
  • RPE65, retinoid isomerohydrolase (Rpe65) Antikörper
  • retinal pigment epithelium-specific protein 65kDa S homeolog (rpe65.S) Antikörper
  • retinal pigment epithelium-specific protein 65kDa L homeolog (rpe65.L) Antikörper
  • RPE65 homolog (rpe65) Antikörper
  • retinal pigment epithelium-specific protein 65kDa (rpe65) Antikörper
  • retinal pigment epithelium-specific protein 65c (rpe65c) Antikörper
  • 65kDa Antikörper
  • A930029L06Rik Antikörper
  • anon-WO0148162.1 Antikörper
  • anon-WO0148163.1 Antikörper
  • beta-diox Antikörper
  • CG9347 Antikörper
  • DmelCG9347 Antikörper
  • DRPE65 Antikörper
  • LCA2 Antikörper
  • MGC52887 Antikörper
  • MGC85437 Antikörper
  • MGC154296 Antikörper
  • Mord1 Antikörper
  • mRPE65 Antikörper
  • rd12 Antikörper
  • RP20 Antikörper
  • RPE56c Antikörper
  • rpe65 Antikörper
  • si:ch211-198n5.12 Antikörper
  • sRPE65 Antikörper

Bezeichner auf Proteinebene für RPE65

RBP-binding membrane protein , all-trans-retinyl-palmitate hydrolase , p63 , retinal pigment epithelium-specific 65 kDa protein , retinitis pigmentosa 20 (autosomal recessive) , retinoid isomerohydrolase , retinol isomerase , modifier of retinal degeneration 1 , retinal pigment epithelium, 65 kDa , neither inactivation nor afterpotential B , CG9347-PA , ninaB-PA , beta-carotene dioxygenase , retinal pigment epithelium 65-like , retinal pigment epithelium-specific protein (65kD) , retinal pigment epithelium-specific protein 65kDa , retinal pigment epithelium abundant protein RPE65 , rpe65 gene for retinal pigment epithelium-specific protein , RPE65 homolog , retinoid isomerohydrolase-like , All-trans-retinyl ester 13-cis isomerohydrolase C , All-trans-retinylester 11-cis isomerohydrolase C , Retinal pigment epithelium-specific 65 kDa protein homolog C , retinal Mueller cells isomerohydrolase

GENE ID SPEZIES
6121 Homo sapiens
19892 Mus musculus
41678 Drosophila melanogaster
89826 Rattus norvegicus
282043 Bos taurus
379961 Xenopus laevis
395700 Gallus gallus
403803 Canis lupus familiaris
447613 Xenopus laevis
701764 Macaca mulatta
744567 Pan troglodytes
778842 Ciona intestinalis
100145692 Xenopus (Silurana) tropicalis
100397525 Callithrix jacchus
100453879 Pongo abelii
100516743 Sus scrofa
100588685 Nomascus leucogenys
100004076 Danio rerio
100219959 Taeniopygia guttata
100352270 Oryctolagus cuniculus
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