anti-Recombination Activating Gene 1 (RAG1) Antikörper

The protein encoded by RAG1 is involved in activation of immunoglobulin V-D-J recombination. Zusätzlich bieten wir Ihnen RAG1 Kits (25) und RAG1 Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
RAG1 84600  
RAG1 5896 P15918
RAG1 19373 P15919
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Top anti-RAG1 Antikörper auf antikoerper-online.de

Showing 10 out of 42 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Pferd Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Maus Unkonjugiert ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Western blot analysis using RAG1 mAb against human RAG1 recombinant protein. (Expected MW is 31.6 kDa) 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$430.10
Details
Maus Kaninchen Unkonjugiert ChIP, WB Western Blot: RAG1 Antibody [NBP1-74190] - Mouse Liver Lysate 1ug/ml Gel Concentration 6-18% 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$556.31
Details
Human Maus Unkonjugiert WB Western blot analysis of Rag-1. Lysate from Jurkat cells was probed with anti- Rag-1 (clone G189-1417) at concentrations of 2.0, 1.0, and 0.5 myg/ml. The antibody identifies Rag-1 as a ~110 kDa band. 0.1 mg Anmelden zum Anzeigen 6 bis 8 Tage
$222.54
Details
Huhn Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Alexa Fluor 594 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Maus Unkonjugiert ELISA, WB ELISA: RAG1 Antibody (1D9) [NBP2-37449] - Red: Control Antigen (100ng); Purple: Antigen (10ng); Green: Antigen (50ng); Blue: Antigen (100ng); Western Blot: RAG1 Antibody (1D9) [NBP2-37449] - Western blot analysis using RAG1 mAb against HEK293 (1) and RAG1 (AA: 818-868)-hIgGFc transfected HEK293 (2) cell lysate. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$514.63
Details
Human Kaninchen Alexa Fluor 555 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen Alexa Fluor 488 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details
Human Kaninchen Cy7 IF (p)   100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$405.90
Details

RAG1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-RAG1 Antikörper

  1. Human Monoclonal RAG1 Primary Antibody für WB - ABIN967402 : Chun, Schatz, Oettinger, Jaenisch, Baltimore: The recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. in Cell 1991 (PubMed)
    Show all 6 Pubmed References

  2. Human Monoclonal RAG1 Primary Antibody für ELISA, WB - ABIN1098121 : Chen, Xiao, Zhang, Li, Liu, Zhao, Ma, Luo, Qiu, Huang, Korteweg, Gu: Transcription factors E2A, FOXO1 and FOXP1 regulate recombination activating gene expression in cancer cells. in PLoS ONE 2011 (PubMed)
    Show all 2 Pubmed References

  3. Mouse (Murine) Polyclonal RAG1 Primary Antibody für ChIP, WB - ABIN4893588 : Zhou, Yu, Chang, Zhang, Zhou, Cammas, Sun: TRIM28 mediates chromatin modifications at the TCRα enhancer and regulates the development of T and natural killer T cells. in Proceedings of the National Academy of Sciences of the United States of America 2012 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen RAG1 Interaktionspartner

Pig (Porcine) Recombination Activating Gene 1 (RAG1) Interaktionspartner

  1. Results confirm that Rag-1 is necessary for the generation of lymphocytes in pigs, and Rag-1-deficient piglets exhibit a T and B cell deficient severe combined immune deficiency(T-B-SCID (zeige PRKDC Antikörper)) phenotype similar to that of rodents and humans.

  2. Piglets with biallelic mutations in either RAG1 or RAG2 (zeige RAG2 Antikörper) exhibit hypoplasia of immune organs, fail to perform V(D)J rearrangement, and lose mature B and T cells.

Human Recombination Activating Gene 1 (RAG1) Interaktionspartner

  1. We report two siblings with SCID (zeige PRKDC Antikörper) and an atypical phenotype of osteopetrosis (OP (zeige CSF1 Antikörper)). A biallelic microdeletion encompassing the 5' region of TRAF6 (zeige TRAF6 Antikörper), RAG1 and RAG2 (zeige RAG2 Antikörper) genes was identified. TRAF6 (zeige TRAF6 Antikörper), a tumor necrosis factor (zeige TNF Antikörper) receptor-associated family member, plays an important role in T cell signaling and in RANKL (zeige TNFSF11 Antikörper)-dependent osteoclast differentiation and activation but its role in human OP has not been previously reported

  2. The show that DNA damage caused by RAG1 activity in pre-B cells was able to downmodulate RAG1 expression and activity, confirming the existence of a negative feedback regulatory mechanism.

  3. Our findings suggest that mutations in RAG1, specifically the p.R474C variant, can be associated with relatively mild clinical symptoms or delayed occurrence of T cell and B cell deficiencies but may predispose to progressive multifocal leukoencephalopathy.

  4. This study compares T-cell development of patients with RAG1-dependent immune deficiencies, and elucidates important differences that help to explain the wide range of immunologic phenotypes that result from different mutations within the same gene of various patients.

  5. Agammaglobulinemia associated to nasal polyposis due to a hypomorphic RAG1 mutation

  6. mutation c.256_257delAA in RAG1 gene seems to occur quite frequently in the Polish patients with severe combined immunodeficiency (zeige PRKDC Antikörper) and may result in classical OS as well as in severe combined immunodeficiency (zeige PRKDC Antikörper) without clinical and laboratory features of OS when occurred in homozygous state

  7. study reported 4 patients with RAG1 deficiency: classic severe combined immune deficiency (SCID (zeige PRKDC Antikörper)) was seen in 2 patients, Omenn syndrome was observed in 1 patient and atypical SCID (zeige PRKDC Antikörper) was seen in one patient

  8. Study reports that RAG1 associates with chromatin at thousands of active promoters and enhancers in the genome of developing lymphocytes. The mouse and human genomes appear to have responded by reducing the abundance of "cryptic" recombination signals near RAG1 binding sites.

  9. These findings provide insight into the role of this poorly understood region of Rag1 and support the role of Rag1 in a post-cleavage stage of recombination

  10. Expression of recombinase RAG-1 in diabetic patients was detected primarily in alphabetaTCR+CD40 (zeige CD40 Antikörper)+ lymphocytes.

Mouse (Murine) Recombination Activating Gene 1 (RAG1) Interaktionspartner

  1. This study demonstrated that the lymphocyte-deficient Rag1 animals demonstrated a significantly lower rate of aneurysm formation and rupture.

  2. This work provides important mechanistic insight into how spatiotemporal expression of the Rag genes is tightly controlled during B lymphocyte (zeige AKAP17A Antikörper) development to prevent mistimed dsDNA breaks and their deleterious consequences.

  3. a novel RAG1/2-mediated insertion pathway distinct from DNA transposition and trans-V(D)J recombination that destabilizes the genome and shares features with reported oncogenic DNA insertions.

  4. loss of the BH3-only (zeige BBC3 Antikörper) protein BIM (zeige BCL2L11 Antikörper) accelerated lymphoma development in p53 (zeige TP53 Antikörper)-deficient mice. This process was negated by concomitant loss of RAG1/2-mediated antigen receptor gene rearrangement.

  5. Nonamer binding domain (NBD) of RAG1 plays a central role in the recognition of recombination signal sequence.

  6. Overall, these findings suggest that the V(D)J recombination-activating gene 1, RAG1, may play a role in long-term memory consolidation.

  7. propose that pre-B cells toggle between pre-BCR (zeige BCR Antikörper) signals and a RAG1 DNA double-strand break-dependent checkpoint to maintain genome stability while iteratively assembling Igl chain genes

  8. Study reports that RAG1 associates with chromatin at thousands of active promoters and enhancers in the genome of developing lymphocytes. The mouse and human genomes appear to have responded by reducing the abundance of "cryptic" recombination signals near RAG1 binding sites.

  9. The non-core region of RAG1 facilitates chromosomal V(D)J recombination in a ubiquitylation-dependent pathway.

  10. Based on our results, we propose that interaction of RAG2 (zeige RAG2 Antikörper) with RAG1 induces cooperative interactions of multiple binding sites, induced through conformational changes at the RAG1 interdomain boundary

Zebrafish Recombination Activating Gene 1 (RAG1) Interaktionspartner

  1. Differential gene expression following TLR stimulation in rag1-/- mutant zebrafish tissues and morphological descriptions of lymphocyte-like cell populations

  2. first report of any rag1(-/-) mutant vertebrate mounting a protective secondary immune response to a bacterial pathogen

  3. target-selected inactivation of the rag1 gene

  4. Rag1 has a role in developing zebrafish cortex-medullary regionalization

  5. by embryonic day 4, rag1 transcripts are seen in the pancreas

  6. Recombination signal sequences are recognized by rag1 protein.

  7. Rag1 expression is restricted to a subpopulation of zebrafish olfactory neurons projecting to the lateral olfactory bulb; Rag11 catalytic activity is not essential for axon targeting

  8. This report describes the leukocyte populations in a unique model, recombination activation gene 1-/- mutant zebrafish (rag1 mutants).

RAG1 Antigen-Profil

Protein Überblick

The protein encoded by this gene is involved in activation of immunoglobulin V-D-J recombination. The encoded protein is involved in recognition of the DNA substrate, but stable binding and cleavage activity also requires RAG2. Defects in this gene can be the cause of several diseases.

Genbezeichner und Symbole assoziert mit RAG1

  • recombination activating 1 (Rag1) Antikörper
  • recombination activating 1 (RAG1) Antikörper
  • recombination activating gene 1 (RAG1) Antikörper
  • recombination activating gene 1 (rag1) Antikörper
  • recombination activating gene 1 (Rag1) Antikörper
  • recombination activating 1 (rag1) Antikörper
  • recombination activating gene 1 S homeolog (rag1.S) Antikörper
  • rag-1 Antikörper
  • rag1 Antikörper
  • rag1a Antikörper
  • RNF74 Antikörper

Bezeichner auf Proteinebene für RAG1

V(D)J recombination-activating protein 1 , recombination activation protein 1 , recombination activating gene 1 , recombination activating protein 1 , recombination-activating gene 1 , recombinase activating protein , V(D)J recombination-activating protein 1-like , RING finger protein 74 , recombinase activating gene 1 , etID309719.25 , recombinase , recombination activating protein

GENE ID SPEZIES
84600 Rattus norvegicus
466489 Pan troglodytes
483420 Canis lupus familiaris
506302 Bos taurus
619389 Monodelphis domestica
697322 Macaca mulatta
100049810 Equus caballus
100077097 Ornithorhynchus anatinus
100145555 Xenopus (Silurana) tropicalis
100395720 Callithrix jacchus
100447109 Pongo abelii
100595879 Nomascus leucogenys
397506 Sus scrofa
5896 Homo sapiens
19373 Mus musculus
423164 Gallus gallus
100328950 Oryctolagus cuniculus
30663 Danio rerio
100136833 Oncorhynchus mykiss
100337558 Xenopus laevis
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