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RIN3 is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases (see RAB5A\; MIM 179512) (Kajiho et al., 2003 [PubMed 12972505]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen RIN3 Antikörper (16) und viele weitere Produktgruppen zu diesem Protein an.
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RIN3 may contribute to Paget's disease of bone susceptibility by affecting osteoclast function.
discovered novel interaction candidates for CD2AP (zeige Cd2ap Proteine) and characterized subtle yet significant differences in the recognition preferences of its three SH3 domains for c-CBL (zeige CBL Proteine), ALIX (zeige PDCD6IP Proteine), and RIN3
The study reports a novel association between a variant within RIN3 and lower limb-bone mineral density and note its previous association with risk of Paget's disease.
RIN3 is a negative regulator of mast cell responses to SCF (zeige KITLG Proteine)
RIN3 specifically acts as a GEF (zeige SLC2A4RG Proteine) for Rab31 (zeige RAB31 Proteine).
RIN3 biochemically characterized as the stimulator and stabilizer for GTP (zeige AK3 Proteine)-Rab5 (zeige RAB5A Proteine) plays an important role in the transport pathway from plasma membrane to early endosomes
Tyrosine-phosphorylation signals are involved in the RIN3 activation and translocation to early endocytic vesicles.
RIN3 is a member of the RIN family of Ras interaction-interference proteins, which are binding partners to the RAB5 small GTPases (see RAB5A\; MIM 179512) (Kajiho et al., 2003
ras and Rab interactor 3
, Ras and Rab interactor 3
, ras and Rab interactor 3-like
, RAB5 interacting protein 3
, ras interaction/interference protein 3
, Ras interaction/interference protein 3