Ras Homolog Gene Family, Member J Proteine (RHOJ)

RHOJ encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). Zusätzlich bieten wir Ihnen Ras Homolog Gene Family, Member J Antikörper (57) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RHOJ 57381 Q9H4E5
Ratte RHOJ RHOJ 299145  
RHOJ 80837 Q9ER71
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 10 bis 12 Tage
$785.40
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RHOJ Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , ,
, ,
Mouse (Murine)

Weitere Proteine zu Ras Homolog Gene Family, Member J (RHOJ) Interaktionspartnern

Human Ras Homolog Gene Family, Member J (RHOJ) Interaktionspartner

  1. Short-term treatment of nascent melanoma tumors with PAK inhibitors that block RhoJ signaling halts the growth of BRAF (zeige BRAF Proteine) mutant melanoma tumors in vivo and induces apoptosis in melanoma cells in vitro via a BAD-dependent mechanism. As up to 50% of BRAF (zeige BRAF Proteine) mutant human melanomas express high levels of RhoJ, these studies nominate the RhoJ-BAD signaling network as a therapeutic vulnerability for fledgling BRAF (zeige BRAF Proteine) mutant human tumor

  2. These results identify amino acids within the N terminus and a loop region distal to the nucleotide binding pocket of TCL capable of allosterically regulating nucleotide exchange and thus influence membrane association of the protein.

  3. FMNL3 interacts with Cdc42 and RhoJ, two Rho family GTPases known to be required for lumen formation. FMNL3 and RhoJ are concentrated at the early apical surface, or AMIS, and regulate the formation of radiating actin cables from this site.

  4. RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. Studies give insight into the molecular function of RhoJ in regulating cell motility.

  5. These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects.

  6. These observations identify RHOJ as a melanoma linchpin determinant that regulates both actin cytoskeletal dynamics and chemoresistance by activating PAK1 (zeige PAK1 Proteine).

  7. Arhgef15 acts as an endothelial cell-specific GEF to mediate VEGF-induced Cdc42 activation and potentiate RhoJ inactivation, thereby promoting actin polymerization and cell motility.

  8. we identified RhoJ and its effector PAK1 (zeige PAK1 Proteine), as key modulators of melanoma cell sensitivity to DNA damage

  9. Our study supports a novel role for the Rho family member RhoJ in ednothelial cell morphogenesis and in particular in lumen formation

  10. RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers.

Mouse (Murine) Ras Homolog Gene Family, Member J (RHOJ) Interaktionspartner

  1. RhoJ-knockout mice showed reduced tumour growth and diminished tumour vessel density, identifying a role for RhoJ in mediating tumour angiogenesis. Studies give insight into the molecular function of RhoJ in regulating cell motility.

  2. These results identify RhoJ blockade as a selective and effective therapeutic strategy for targeting tumor vasculature with minimal side effects.

  3. RhoJ is endothelial-expressed in vivo, activated by vascular endothelial growth factor, localizes to focal adhesions, regulates endothelial cell migration and tube formation, and modulates actomyosin contractility and focal adhesion numbers.

  4. The results strongly suggest that TCL/TC10betaL regulates adipocyte differentiation by controlling mitotic clonal expansion and this regulatory effect is closely linked to C/EBPbeta (zeige CEBPB Proteine) and C/EBPdelta (zeige CEBPD Proteine) expression.

  5. TCL/TC10betaL has a crucial role in the early stage of adipocyte differentiation, is probably linked to the PPARgamma (zeige PPARG Proteine) pathway, and up-regulates epression of genes associated with adipogenesis.

  6. Insulin (zeige INS Proteine) induces phosphatidylinositol 3-phosphate formation through TC10 (zeige RHOQ Proteine) activation.

Ras Homolog Gene Family, Member J (RHOJ) Protein Überblick

Protein Überblick

This gene encodes one of the many small GTP-binding proteins in the Rho family shown to be associated with focal adhesions in endothelial cells (PMID: 21148427, 22103495). The encoded protein is activated by vascular endothelial growth factor and may regulate angiogenesis.

Genbezeichner und Symbole assoziert mit RHOJ

  • ras homolog family member J (RHOJ)
  • ras homolog family member J L homeolog (rhoj.L)
  • ras homolog family member J (rhoj)
  • ras homolog family member J (Rhoj)
  • 1110005O19Rik Protein
  • Arhj Protein
  • AW210585 Protein
  • MGC83410 Protein
  • RASL7B Protein
  • RHOJ Protein
  • si:dkey-100h21.1 Protein
  • TC10B Protein
  • TC10L Protein
  • TCL Protein

Bezeichner auf Proteinebene für RHOJ

ras homolog gene family, member J , TC10-like Rho GTPase , rho-related GTP-binding protein RhoJ , RAS-like, family 7, member B , ras-like protein family member 7B , tc10-like GTP-binding protein , tc10-like GTP-binding protein TCL

GENE ID SPEZIES
423513 Gallus gallus
444554 Xenopus laevis
452960 Pan troglodytes
540619 Bos taurus
556371 Danio rerio
612985 Canis lupus familiaris
705603 Macaca mulatta
100125013 Xenopus (Silurana) tropicalis
100155474 Sus scrofa
100350942 Oryctolagus cuniculus
57381 Homo sapiens
299145 Rattus norvegicus
80837 Mus musculus
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