Ras Association Domain-Containing Protein 6 Proteine (RASSF6)

RASSF6 encodes a member of the Ras-association domain family (RASSF). Zusätzlich bieten wir Ihnen RASSF6 Antikörper (59) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
RASSF6 166824 Q6ZTQ3
RASSF6 73246 Q80UQ2
RASSF6 305251 Q4QR82
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,924.17
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RASSF6 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human

Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Ras Association Domain-Containing Protein 6 (RASSF6) Interaktionspartnern

Human Ras Association Domain-Containing Protein 6 (RASSF6) Interaktionspartner

  1. RASSF6 and RASSF10 were frequently hypermethylated in the samples at the time of diagnosis of adult acute lymphoblastic leukemia patients

  2. Overexpression or silencing of RASSF6 could partially reverse the effects of the overexpression or repression of miR (zeige MLXIP Proteine)-181a-5p on GC progress caused by activation of the MAKP pathway in vitro and in vivo.

  3. Results suggest that down-regulation of RASSF2 (zeige RASSF2 Proteine), and RASSF6 is a tumor-specific phenomenon and their inactivation through CpG island methylation may play important roles in gastric cardia carcinogenesis.

  4. Mechanistic investigation shows that RASSF6 triggers p21(Cip1/Waf1 (zeige CDKN1A Proteine)) accumulation to induce G 1 cell cycle arrest and promote apoptosis upon exposure to pro-apoptotic agents, and both of these mechanisms appear to be mediated by activated JNK (zeige MAPK8 Proteine) signaling.

  5. RASSF6 expression is an independent biomarker of an unfavorable prognosis in patients with pancreatic ductal adenocarcinoma.

  6. RASSF6 exhibits promoter hypermethylation in metastatic melanoma and inhibits invasion in melanoma cells.RASSF6 exhibits the highest frequency of inactivation in melanoma and in melanoma brain metastases.

  7. downregulation of RASSF6 in highly metastatic nasopharyngeal carcinoma cells contributed to their treatment resistance

  8. RASSF6-induced apoptosis partially depends on p53 (zeige TP53 Proteine). RASSF6 binds MDM2 (zeige MDM2 Proteine) and facilitates its ubiquitination. RASSF6 depletion blocks the increase of p53 (zeige TP53 Proteine) in response to UV exposure and up-regulation of p53 (zeige TP53 Proteine) target genes.

  9. The RASSF gene family members RASSF5 (zeige RASSF5 Proteine), RASSF6 and RASSF7 show frequent DNA methylation (zeige HELLS Proteine) in neuroblastoma (zeige ARHGEF16 Proteine).

  10. Decreased expression of RASSF6 is associated with gastric cancer.

Mouse (Murine) Ras Association Domain-Containing Protein 6 (RASSF6) Interaktionspartner

  1. RASSF6 expression in adipocytes is down-regulated by interaction with macrophages.

  2. Demonstrates properties of a Ras effector and tumor suppressor but exhibits biological properties that are unique and distinct from those of other family members.

RASSF6 Protein Überblick

Protein Überblick

This gene encodes a member of the Ras-association domain family (RASSF). Members of this family form the core of a highly conserved tumor suppressor network, the Salvador-Warts-Hippo (SWH) pathway. The protein encoded by this gene is a Ras effector protein that induces apoptosis. A genomic region containing this gene has been linked to susceptibility to viral bronchiolitis. Alternative splicing results in multiple transcript variants and protein isoforms.

Genbezeichner und Symbole assoziert mit RASSF6

  • Ras association domain family member 6 (RASSF6)
  • Ras association (RalGDS/AF-6) domain family member 6 (Rassf6)
  • Ras association (RalGDS/AF-6) domain family 6 (rassf6)
  • Ras association domain family member 6 (Rassf6)
  • 1600016B17Rik Protein
  • im:7154480 Protein
  • si:dz57f23.2 Protein
  • zgc:136957 Protein

Bezeichner auf Proteinebene für RASSF6

Ras association (RalGDS/AF-6) domain family 6 , putative RAS binding protein , ras association domain-containing protein 6

GENE ID SPEZIES
166824 Homo sapiens
73246 Mus musculus
751594 Danio rerio
305251 Rattus norvegicus
Ausgewählte Anbieter für RASSF6 Proteine (RASSF6)
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