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The protein encoded by RAB2A belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. Zusätzlich bieten wir Ihnen RAB2A, Member RAS Oncogene Family Antikörper (78) und viele weitere Produktgruppen zu diesem Protein an.
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Human RAB2A Protein expressed in Escherichia coli (E. coli) - ABIN667923
Opdam, Kamps, Croes, van Bokhoven, Ginsel, Fransen: Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells. in European journal of cell biology 2000
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RAB2A variance has effect on the structure and function of the PFC (zeige CFP Proteine) and related cognitive functions.
This study demonstrated that RAB2A mutation showing the highest statistical significance in Autism and Schizophrenia.
The immunohistochemistry-based validation using tissue microarray slides in oral squamous cell carcinoma revealed overexpression of the RAB2A and PRDX1 (zeige PRDX1 Proteine) gene in 80 and 68 % of the tested clinical cases, respectively.
Pin1 (zeige PIN1 Proteine)/Rab2A/Erk (zeige EPHB2 Proteine) drives BCSC expansion and tumorigenicity, suggesting potential drug targets.
As a result of the translocations, RAB2A-PLAG1 (zeige PLAG1 Proteine), the constitutively active promoter of the partner gene drives the ectopic expression of PLAG1 (zeige PLAG1 Proteine).
first X-ray crystal structure of RicA to 2.7 A resolution and have quantified the affinity of RicA binding to human Rab2 in its GDP-bound and nucleotide-free forms
The authors identified a specific interaction between the human small GTPase Rab2 and a Brucella spp. protein named RicA.
The results of this study provided that RAB2A and SLC38A1, were associated with the density of calbindin (zeige CALB1 Proteine)-positive neurons and the number of perineuronal oligodendrocytes in psychiatric disorders.
Rab2 interacts directly with atypical protein kinase C (zeige PRKCZ Proteine) iota (zeige PRKCI Proteine)/lambda and inhibits aPKCiota/lambda-dependent GADPH (zeige GAPDH Proteine) phosphorylation
These data demonstrate that Rab2 and Rab6 differentially influence anterograde transport and signaling of GPCRs.
An unprecedented direction of RAB2A-mediated vesicular transport in spermatids during acrosomal biogenesis, from the trans-side of the Golgi apparatus to the nuclear envelope.
Symbiotic bacteria directed selective cargo sorting in Paneth cells to promote symbiosis through Nod2 and LRRK2 (zeige LRRK2 Proteine). Deficiency of Nod2, LRRK2 (zeige LRRK2 Proteine) or Rab2a or depletion of commensals resulted in lysosomal degradation of lysozyme (zeige LYZ Proteine).
Rab2A is a pivotal switch protein that promotes either secretion or endoplasmic reticulum-associated degradation of (pro)insulin (zeige INS Proteine) in insulin (zeige INS Proteine)-secreting cells.
CSFV proliferation was promoted by GBF1 and Rab2 overexpression using a lentiviral system. Hence, Golgi function is important for CSFV multiplication, and GBF1 and Rab2 participate in CSFV proliferation.
The protein encoded by this gene belongs to the Rab family, members of which are small molecular weight guanosine triphosphatases (GTPases) that contain highly conserved domains involved in GTP binding and hydrolysis. The Rabs are membrane-bound proteins, involved in vesicular fusion and trafficking. This protein is a resident of pre-Golgi intermediates, and is required for protein transport from the endoplasmic reticulum (ER) to the Golgi complex. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
RAB2, member RAS oncogene family
, ras-related protein Rab-2A
, RAB2A, member RAS oncogene family
, GTP-binding protein
, small GTP binding protein RAB2A
, GTP-binding protein (rab2)
, tubulovesicle-membrane-associated GTP-binding protein