Protein tyrosine Phosphatase, Non-Receptor Type 14 Proteine (PTPN14)

The protein encoded by PTPN14 is a member of the protein tyrosine phosphatase (PTP) family. Zusätzlich bieten wir Ihnen PTPN14 Antikörper (41) und PTPN14 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PTPN14 5784 Q15678
PTPN14 19250 Q62130
PTPN14 305064  
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Showing 3 out of 3 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_Escherichia coli (E. coli) Ratte T7 tag,His tag   100 μg Anmelden zum Anzeigen 13 bis 17 Tage
612,38 €
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PTPN14 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human

Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Protein tyrosine Phosphatase, Non-Receptor Type 14 (PTPN14) Interaktionspartnern

Human Protein tyrosine Phosphatase, Non-Receptor Type 14 (PTPN14) Interaktionspartner

  1. study determined that high-risk E7 proteins target the proteolysis of the cellular protein tyrosine phosphatase (zeige ACP1 Proteine) PTPN14 and find that this activity is correlated with the retinoblastoma-independent transforming activity of E7

  2. PTPN14 is classified as a potential tumor suppressor protein (zeige TP53 Proteine), and is very susceptible to HPV E7-induced proteasome-mediated degradation.

  3. The Hippo signaling pathway was significantly associated with ER-negative breast cancer (pathway level P = 0.02). Gene-based analyses revealed that CDH1 (zeige CDH1 Proteine) was responsible for the pathway association (P < 0.01),corrected P = 0.02). rs142697907 in PTPN14 was associated with ER-positive breast cancer and rs2456773 in CDK1 (zeige CDK1 Proteine) with ER-negativity in case-only analysis after gene-level correction

  4. PTPN14, a Pez mammalian homolog, is degraded by overexpressed Su(dx) or Su(dx) homologue WWP1 (zeige WWP1 Proteine) in mammalian cells.

  5. PTPN14 and PTEN were identified as direct and functional targets of miR (zeige MLXIP Proteine)-21.

  6. Findings indicate a pathway involving protein-tyrosine phosphatase (zeige ACP1 Proteine) D2 PTPD2 (PTPN14) and the lipid second messenger phosphatidic acid that promotes ERBB2 (zeige ERBB2 Proteine) receptor function.

  7. results indicate a potential regulatory role of PTPN14 in the Hippo pathway and demonstrate another layer of regulation in the YAP (zeige YAP1 Proteine) oncogenic function

  8. Data demonstrate that PTPN14 downregulation can phenocopy YAP (zeige YAP1 Proteine) activation in mammary epithelial cells and synergize with YAP (zeige YAP1 Proteine) to induce oncogenic transformation.

  9. Data show that p130 (zeige RBL2 Proteine) Crk-associated substrate (zeige BCAR1 Proteine) is a direct substrate of PTPN14 and that PTPN14 specifically regulates p130Cas (zeige BCAR1 Proteine) phosphorylation at tyrosine residue 128 in colorectal cancer cells.

  10. YAP (zeige YAP1 Proteine) is a direct substrate of PTPN14. Results indicate a potential regulatory role of PTPN14 on YAP (zeige YAP1 Proteine) and demonstrate a novel mechanism in YAP (zeige YAP1 Proteine) regulation.

Mouse (Murine) Protein tyrosine Phosphatase, Non-Receptor Type 14 (PTPN14) Interaktionspartner

  1. The tyrosine phosphatase PTPN14 (Pez) inhibits metastasis by altering protein trafficking.

  2. PTPN14 has a role in angiogenesis and/or arteriovenous fate, acting via EphrinB2 (zeige EFNB2 Proteine) and ACVRL1/activin receptor-like kinase 1 (zeige ACVRL1 Proteine)

PTPN14 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an N-terminal noncatalytic domain similar to that of band 4.1 superfamily cytoskeleton-associated proteins, which suggested the membrane or cytoskeleton localization of this protein. It appears to regulate lymphatic development in mammals, and a loss of function mutation has been found in a kindred with a lymphedema-choanal atresia.

Genbezeichner und Symbole assoziert mit PTPN14

  • protein tyrosine phosphatase, non-receptor type 14 (PTPN14)
  • protein tyrosine phosphatase, non-receptor type 14 (Ptpn14)
  • C130080N23Rik Protein
  • OTTMUSG00000022087 Protein
  • PEZ Protein
  • PTP36 Protein

Bezeichner auf Proteinebene für PTPN14

cytoskeletal-associated protein tyrosine phosphatase , protein-tyrosine phosphatase pez , tyrosine-protein phosphatase non-receptor type 14 , protein-tyrosine phosphatase PTP36

GENE ID SPEZIES
5784 Homo sapiens
19250 Mus musculus
305064 Rattus norvegicus
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