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The protein encoded by PPM1A is a member of the PP2C family of Ser/Thr protein phosphatases. Zusätzlich bieten wir Ihnen Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Antikörper (111) und Protein Phosphatase, Mg2+/Mn2+ Dependent, 1A Proteine (18) und viele weitere Produktgruppen zu diesem Protein an.
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Human PPM1A ELISA Kit für Sandwich ELISA - ABIN422937
Kim, Sohn, Zhao, Sokolove, Lindstrom, Yoo, Lee, Reveille, Taurog, Robinson: Role of protein phosphatase magnesium-dependent 1A and anti-protein phosphatase magnesium-dependent 1A autoantibodies in ankylosing spondylitis. in Arthritis & rheumatology (Hoboken, N.J.) 2014
findings demonstrate a novel regulatory circuit in which STING and TBK1 (zeige TBK1 ELISA Kits) reciprocally regulate each other to enable efficient antiviral signaling activation, and PPM1A dephosphorylates STING and TBK1 (zeige TBK1 ELISA Kits)
the studies presented here position PPM1A as a new player in the wound healing-inflammation-angiogenesis axis in mouse, reveal its crucial role in homeostasis on injury, and highlight its potential as a therapeutic mediator in pathologic conditions
a nuclear envelope-localized mechanism of inactivating TGF-beta (zeige TGFB1 ELISA Kits) signaling in which MAN1 (zeige LEMD3 ELISA Kits) competes with transcription factors for binding to Smad2 (zeige SMAD2 ELISA Kits) and Smad3 (zeige SMAD3 ELISA Kits) and facilitates their dephosphorylation by PPM1A.
Although a non-myristoylated mutation (G2A) of PPM1A and PPM1B (zeige PPM1B ELISA Kits) prevented membrane association, this relocalization did not likely cause the decreased activity towards AMPKalpha (zeige GRK4 ELISA Kits).
we found that PPM1A mRNA is synthesized at the beginning of the maturation process and remains elevated in the mature oocytes, promoting the accumulation of PPM1A protein
Protein phosphatase PPM1A regulates the nuclear export of Smad2 (zeige SMAD2 ELISA Kits)/3 through targeting nuclear exporter RanBP3 (zeige RANBP3 ELISA Kits).
Ppm1a, through suppressing Smad2 (zeige SMAD2 ELISA Kits) signaling, plays a critical role in re-epithelialization during wound healing
Molecular cloning and expression analysis of MPP alpha-2, a novel transcript detected in a differential screen of pituitary libraries (MPPalpha 2)
Protein phosphatase 1alpha is required for lung growth and morphogenesis.
These data suggest that PPM1A, which had previously been shown to play a role in the antiviral response to Herpes Simplex virus infection, also governs the antibacterial response of macrophages to bacteria, or at least to Mycobacterium tuberculosis infection
establish PPM1A as a novel repressor of the SMAD3 (zeige SMAD3 ELISA Kits) pathway in renal fibrosis
Report a tumor-suppressive function of PPM1A and an independent relationship to Smad4 (zeige SMAD4 ELISA Kits) in pancreatic ductal adenocarcinoma.
hydrogen/deuterium exchange-mass spectrometry and molecular dynamics to characterize conformational changes in PP2Calpha between the active and inactive states
In a nested case control study of ischemic stroke, there was an epigenome-wide association for cg04985020 (PPM1A; P=1.78x10(-07)) with vascular recurrence in patients treated with aspirin.
The TGF-beta (zeige TGFB1 ELISA Kits)/Smad (zeige SMAD1 ELISA Kits) signaling system decreases its activity through strong negative regulation. We provide evidence for a new negative feedback loop through PPM1A upregulation.
Loss of PPM1A is associated with the development of tumor invasion in bladder cancer patients.
PPM1A is a RelA (zeige NFkBP65 ELISA Kits) phosphatase that regulates NF-kappaB (zeige NFKB1 ELISA Kits) activity and that PPM1A has tumor suppressor-like activity.
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase dephosphorylates, and negatively regulates the activities of, MAP kinases and MAP kinase kinases. It has been shown to inhibit the activation of p38 and JNK kinase cascades induced by environmental stresses. This phosphatase can also dephosphorylate cyclin-dependent kinases, and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. Three alternatively spliced transcript variants encoding distinct isoforms have been described.
, protein phosphatase 1A
, protein phosphatase 2C isoform alpha
, protein phosphatase IA
, protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
, Protein phosphatase type 1A (formely 2C) Mg-dependent alpha isoform
, Protein phosphatase type 1A (formely 2C), Mg-dependent, alpha isoform
, protein phosphatase 1A, magnesium dependent, alpha isoform
, protein phosphatase 2C alpha
, protein phosphatase type 2C alpha 2
, protein phosphatase 1A, magnesium dependent, alpha