Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteine (KCNH2)

KCNH2 encodes a voltage-activated potassium channel belonging to the eag family. Zusätzlich bieten wir Ihnen Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Antikörper (94) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
KCNH2 3757 Q12809
KCNH2 16511  
Ratte KCNH2 KCNH2 117018 O08962
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Top Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteine auf antikoerper-online.de

Showing 4 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Wheat germ Human Unkonjugiert   2 μg Anmelden zum Anzeigen 7 bis 8 Tage
406,59 €
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KCNH2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,
Mouse (Murine)
,

Weitere Proteine zu Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaktionspartnern

Zebrafish Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaktionspartner

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. The data support the conclusion that zerg-2 and zerg-3 are apparent orthologues of different human genes encoding potassium ion channels, but that their functions have switched compared to the respective human proteins.

  3. role for ERG in leukocytes, where inhibition or translational knockdown of ERG resulted in significant attenuation of the inflammatory response to an infectious stimulus

  4. Mutations in kcnh2 recapitulate the human long QT syndrome (LQTS) phenotype as manifested by prolongation of action potentials and prolonged QT interval in the first animal genetic model of human LQTS type 2.

  5. The reg mutation in the voltage sensor of the ether-a-go-go-related gene gene K+ channel (zeige KCNC4 Proteine) causes premature zERG channel activation & defective inactivation, resulting in shortened action-potential duration & accelerated cardiac repolarization

Human Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaktionspartner

  1. atypical sequence of the pore helix of hERG may play a key role in determining how anionic lipids influence its gating

  2. Besides a prolonged cardiac repolarization phase, LQT2 patients display increased GLP-1 (zeige GCG Proteine), GIP (zeige GIP Proteine), and insulin (zeige INS Proteine) secretion and defective glucagon (zeige GCG Proteine) secretion, causing decreased plasma glucose and thus increased risk of hypoglycemia.

  3. BIMU8 is a potent blocker of hERG, NaV1.5 (zeige SCN5A Proteine) and CaV1.2 (zeige CACNA1C Proteine) cardiac ion channels, inducing cardiac arrhythmias.

  4. The K897T polymorphism in the hERG1 gene has been reported as an important modifier of the IKr current, probably leading to QT interval prolongation-as it is observed in the LQT2 syndrome.

  5. Stabilization of the Activated hERG Channel Voltage Sensor by Depolarization Involves the S4-S5 Linker

  6. Study determined the structure of hERG using cryo-electron microscopy; the voltage sensors are depolarized, and the inner helical gate is open; an unusual geometry of the "central cavity" within hERG's ion conduction pathway; hERG contains a subtle difference in the structure of its selectivity filter compared to all other K+ channels so far analyzed.

  7. S1 region mutations would reduce both the action potential repolarizing current passed by Kv11.1 channels in cardiac myocytes, as well as the current passed in response to premature depolarizations that normally helps protect against the formation of ectopic beats.

  8. hERG mediated by proteases such as calpain may contribute to ischemia-associated QT prolongation and sudden cardiac death

  9. the two tyrosine residues in the Kv11.1 S4S5 linker play critical but distinct roles in the slow deactivation phenotype, which is a hallmark of Kv11.1 channels.

  10. Authors found that expression of HERG K(+) channels in MDS (zeige PAFAH1B1 Proteine) patients was significantly higher than controls and was lower than AML (zeige RUNX1 Proteine).

Rabbit Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaktionspartner

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. In transgenic long QT syndrome rabbits, Kv11.1 channel activation shortens the cardiac activation potential duration.

Mouse (Murine) Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaktionspartner

  1. Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 (zeige NKX2-5 Proteine) regulates the gene encoding Kcnh2 channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 (zeige NKX2-5 Proteine) dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies

  2. Report altered protein trafficking/function of mouse ERG K(+) channel clones.

  3. Enhancement of HERG protein expression through Hsp90 (zeige HSP90 Proteine) inhibition of CHIP binding might be a novel therapeutic strategy for long QT syndrome 2 caused by trafficking abnormalities of HERG proteins.

  4. The findings of this study suggested that MERG1a may not modulate Murf1 (zeige TRIM63 Proteine) expression through the AKT (zeige AKT1 Proteine)/FOXO (zeige FOXO3 Proteine) pathway.

  5. Data indicate presence of KCNH2 in left/right atria & indicate functional interaction between KCNH2 & KCNA5 (zeige KCNA5 Proteine). Kinetic analyses confirm KCNH2 as "rapid" and KCNA5 (zeige KCNA5 Proteine) as "ultra rapid" potassium channels.

  6. Knockdown of mERG1 transcripts with small interfering RNA (siRNA) dramatically reduced I (Kr) amplitude, confirming the molecular link of mERG1 and I (Kr) in HL-1 (zeige ASGR1 Proteine) cells.

  7. The LQT2 missense mutations G601S and N470D hERG exhibited altered protein trafficking in mouse cardiomyocytes.

  8. ERG1 B is necessary for I(Kr) expression in the surface membrane of adult myocytes. Knockout of ERG1 B predisposes mice to episodic sinus bradycardia.

  9. erg1 gene expression pattern in the developing embryo.

  10. MERG1A is developmentally regulated, and it might play a role in early mouse embryogenic development.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Protein Überblick

Protein Überblick

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.

Genbezeichner und Symbole assoziert mit KCNH2

  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (kcnh2)
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2)
  • potassium voltage-gated channel subfamily H member 2-like (LOC100858122)
  • potassium voltage-gated channel subfamily H member 2-like (LOC100523293)
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (Kcnh2)
  • potassium voltage-gated channel, subfamily H (eag-related), member 6 (KCNH6)
  • AI326795 Protein
  • cerg Protein
  • derg Protein
  • ERG Protein
  • erg1 Protein
  • gp-erg Protein
  • HERG Protein
  • HERG1 Protein
  • KCNH2 Protein
  • Kv11.1 Protein
  • LQT Protein
  • Lqt2 Protein
  • M-erg Protein
  • Merg1 Protein
  • merg1a Protein
  • merg1b Protein
  • SQT1 Protein

Bezeichner auf Proteinebene für KCNH2

bre , breakdance , erg K+ channel , reg , reggae , silent ventricle , unm s213 , zerg , potassium voltage-gated channel, subfamily H (eag-related), member 2 , potassium voltage-gated channel subfamily H member 2-like , ERG-1 , H-ERG , eag homolog , eag-related protein 1 , ether-a-go-go-related gene potassium channel 1 , ether-a-go-go-related potassium channel protein , ether-a-go-go-related protein 1 , hERG-1 , potassium voltage-gated channel subfamily H member 2 , voltage-gated potassium channel subunit Kv11.1 , c-ERG , eag related protein 1 , ether-a-go-go related gene potassium channel 1 , potassium channel protein ERG , ERG1 , RERG , ra-erg , ventricular ERG K+ channel subunit , voltage-gated potassium channel 11.1 , voltage-gated potassium channel, subfamily H, member 2 , MERG , ether a go-go related , r-ERG , Ether-a-go-go-related gene potassium channel 1 , Potassium voltage-gated channel subfamily H member 2 , HERG protein

GENE ID SPEZIES
405763 Danio rerio
463894 Pan troglodytes
100064000 Equus caballus
100413935 Callithrix jacchus
100447585 Pongo abelii
100858122 Gallus gallus
100523293 Sus scrofa
3757 Homo sapiens
403761 Canis lupus familiaris
100009242 Oryctolagus cuniculus
16511 Mus musculus
117018 Rattus norvegicus
397334 Sus scrofa
100135563 Cavia porcellus
414871 Gallus gallus
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