Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteine (KCNH2)

KCNH2 encodes a voltage-activated potassium channel belonging to the eag family. Zusätzlich bieten wir Ihnen Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Antikörper (94) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
KCNH2 3757 Q12809
KCNH2 16511  
Ratte KCNH2 KCNH2 117018 O08962
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Top Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 Proteine auf antikoerper-online.de

Showing 4 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$5,442.50
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
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Wheat germ Human Unkonjugiert   2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$491.43
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KCNH2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
, ,
Mouse (Murine)
,

Weitere Proteine zu Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaktionspartnern

Human Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaktionspartner

  1. In HEK293 cells, CO inhibited wild-type, but not C723S mutant, Kv11.1 K(+) currents. Inhibition was prevented by an antioxidant, mitochondrial inhibitors, or inhibition of NO formation.

  2. data provide novel information about hypoxia-mediated hERG dysfunction and may have biological and clinical implications in hypoxia-associated diseases.

  3. Relative expression of Kv11.1 C-terminal isoforms can be regulated by modified U1 snRNA.

  4. Expression and functions of hERG are regulated by specific miRNAs.

  5. The present study shows clinical and genetic aspects of p.His492Tyr carriers and demonstrated two major findings; (1) KCNH2 p.His492Tyr variant presented symptomatic Romano-Ward syndrome in the presence of another LQTS-related gene mutation, in contrast, (2) heterozygous carriers had mild QT prolongation while additional triggers can be "latent" form of p.His492Tyr

  6. Homozygous carriers of CYP2B6 (zeige CYP2B6 Proteine)*6 allele may be at increased risk for EFV-induced QT interval prolongation via inhibition of hERG.

  7. ER-located J-protein chaperones were identified as key regulators for the iogenesis and physiological function of ERG (zeige ERG Proteine) K+ channels. They regulate two distinct aspects of K+ channel (zeige KCNC4 Proteine) biogenesis, the stabilization and assembly of channel subunits.

  8. atypical sequence of the pore helix of hERG may play a key role in determining how anionic lipids influence its gating

  9. Besides a prolonged cardiac repolarization phase, LQT2 patients display increased GLP-1 (zeige GCG Proteine), GIP (zeige GIP Proteine), and insulin (zeige INS Proteine) secretion and defective glucagon (zeige GCG Proteine) secretion, causing decreased plasma glucose and thus increased risk of hypoglycemia.

  10. BIMU8 is a potent blocker of hERG, NaV1.5 (zeige SCN5A Proteine) and CaV1.2 (zeige CACNA1C Proteine) cardiac ion channels, inducing cardiac arrhythmias.

Zebrafish Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaktionspartner

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. The data support the conclusion that zerg-2 and zerg-3 are apparent orthologues of different human genes encoding potassium ion channels, but that their functions have switched compared to the respective human proteins.

  3. role for ERG in leukocytes, where inhibition or translational knockdown of ERG resulted in significant attenuation of the inflammatory response to an infectious stimulus

  4. Mutations in kcnh2 recapitulate the human long QT syndrome (LQTS) phenotype as manifested by prolongation of action potentials and prolonged QT interval in the first animal genetic model of human LQTS type 2.

  5. The reg mutation in the voltage sensor of the ether-a-go-go-related gene gene K+ channel (zeige KCNC4 Proteine) causes premature zERG channel activation & defective inactivation, resulting in shortened action-potential duration & accelerated cardiac repolarization

Guinea Pig Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaktionspartner

  1. data suggest that CO induces arrhythmias in guinea pig cardiac myocytes via the ONOO(-)-mediated inhibition of Kv11.1 (zeige KCNV2 Proteine) K(+) channels

Mouse (Murine) Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaktionspartner

  1. Using a combination of mouse genetics, biochemistry, molecular and cell biology, we demonstrate that Nkx2-5 (zeige NKX2-5 Proteine) regulates the gene encoding Kcnh2 channel and others, shedding light on potential mechanisms generating electrical abnormalities observed in patients bearing NKX2-5 (zeige NKX2-5 Proteine) dysfunction and opening opportunities to the study of novel therapeutic targets for anti-arrhythmogenic therapies

  2. Report altered protein trafficking/function of mouse ERG K(+) channel clones.

  3. Enhancement of HERG protein expression through Hsp90 (zeige HSP90 Proteine) inhibition of CHIP binding might be a novel therapeutic strategy for long QT syndrome 2 caused by trafficking abnormalities of HERG proteins.

  4. The findings of this study suggested that MERG1a may not modulate Murf1 (zeige TRIM63 Proteine) expression through the AKT (zeige AKT1 Proteine)/FOXO (zeige FOXO3 Proteine) pathway.

  5. Data indicate presence of KCNH2 in left/right atria & indicate functional interaction between KCNH2 & KCNA5 (zeige KCNA5 Proteine). Kinetic analyses confirm KCNH2 as "rapid" and KCNA5 (zeige KCNA5 Proteine) as "ultra rapid" potassium channels.

  6. Knockdown of mERG1 transcripts with small interfering RNA (siRNA) dramatically reduced I (Kr) amplitude, confirming the molecular link of mERG1 and I (Kr) in HL-1 (zeige ASGR1 Proteine) cells.

  7. The LQT2 missense mutations G601S and N470D hERG exhibited altered protein trafficking in mouse cardiomyocytes.

  8. ERG1 B is necessary for I(Kr) expression in the surface membrane of adult myocytes. Knockout of ERG1 B predisposes mice to episodic sinus bradycardia.

  9. erg1 gene expression pattern in the developing embryo.

  10. MERG1A is developmentally regulated, and it might play a role in early mouse embryogenic development.

Rabbit Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Interaktionspartner

  1. RNF207 is an important regulator of action potential duration, likely via effects on HERG trafficking and localization in a heat shock protein-dependent manner.

  2. In transgenic long QT syndrome rabbits, Kv11.1 channel activation shortens the cardiac activation potential duration.

Potassium Voltage-Gated Channel, Subfamily H (Eag-Related), Member 2 (KCNH2) Protein Überblick

Protein Überblick

This gene encodes a voltage-activated potassium channel belonging to the eag family. It shares sequence similarity with the Drosophila ether-a-go-go (eag) gene. Mutations in this gene can cause long QT syndrome type 2 (LQT2). Transcript variants encoding distinct isoforms have been identified.

Genbezeichner und Symbole assoziert mit KCNH2

  • potassium voltage-gated channel subfamily H member 2 (KCNH2)
  • potassium voltage-gated channel, subfamily H (eag-related), member 6a (kcnh6a)
  • potassium voltage-gated channel subfamily H member 2 (Kcnh2)
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (Kcnh2)
  • potassium voltage-gated channel subfamily H member 6 (KCNH6)
  • potassium voltage-gated channel, subfamily H (eag-related), member 2 (KCNH2)
  • AI326795 Protein
  • cerg Protein
  • derg Protein
  • ERG Protein
  • erg1 Protein
  • gp-erg Protein
  • HERG Protein
  • HERG1 Protein
  • KCNH2 Protein
  • Kv11.1 Protein
  • LQT Protein
  • Lqt2 Protein
  • M-erg Protein
  • Merg1 Protein
  • merg1a Protein
  • merg1b Protein
  • SQT1 Protein

Bezeichner auf Proteinebene für KCNH2

ERG-1 , H-ERG , eag homolog , eag-related protein 1 , ether-a-go-go-related gene potassium channel 1 , ether-a-go-go-related potassium channel protein , ether-a-go-go-related protein 1 , hERG-1 , potassium voltage-gated channel subfamily H member 2 , voltage-gated potassium channel subunit Kv11.1 , bre , breakdance , erg K+ channel , reg , reggae , silent ventricle , unm s213 , zerg , potassium voltage-gated channel, subfamily H (eag-related), member 2 , potassium channel protein ERG , potassium voltage-gated channel subfamily H member 2-like , c-ERG , eag related protein 1 , ether-a-go-go related gene potassium channel 1 , MERG , ether a go-go related , RERG , r-ERG , ERG1 , ra-erg , ventricular ERG K+ channel subunit , voltage-gated potassium channel 11.1 , voltage-gated potassium channel, subfamily H, member 2 , HERG protein

GENE ID SPEZIES
3757 Homo sapiens
405763 Danio rerio
463894 Pan troglodytes
100064000 Equus caballus
100135563 Cavia porcellus
100413935 Callithrix jacchus
100447585 Pongo abelii
403761 Canis lupus familiaris
16511 Mus musculus
117018 Rattus norvegicus
100009242 Oryctolagus cuniculus
414871 Gallus gallus
100858122 Gallus gallus
100523293 Sus scrofa
539971 Bos taurus
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