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Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Zusätzlich bieten wir Ihnen KCNA3 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Mammalian Monoclonal KCNA3 Primary Antibody für ISt, IHC - ABIN1304749
Cidad, Novensà, Garabito, Batlle, Dantas, Heras, López-López, Pérez-García, Roqué: K+ channels expression in hypertension after arterial injury, and effect of selective Kv1.3 blockade with PAP-1 on intimal hyperplasia formation. in Cardiovascular drugs and therapy / sponsored by the International Society of Cardiovascular Pharmacotherapy 2014
Show all 21 Pubmed References
the tertiary structure of the C-terminal domain of Kv1.3 is necessary and sufficient for Kv1.3- KCNE4 (zeige KCNE4 Antikörper) interaction.
results identify a caveolin-binding domain in Kv1 (zeige KCNA5 Antikörper) channels and highlight the mechanisms that govern the regulation of channel surface localization during cellular processes
we report that Kv1.3-NPs (zeige NPS Antikörper) reduced NFAT (zeige NFATC1 Antikörper) activation and CD40L (zeige CD40LG Antikörper) expression exclusively in CD45RO(+) T cells. Furthermore, Kv1.3-NPs (zeige NPS Antikörper) suppressed cytokine release and induced a phenotype switch of T cells from predominantly memory to naive.
The implication of Kv1.3 in a wide repertoire of human pathologies indicates this channel is an important therapeutic target.
Results contribute to the characterization of leukemic B cells, as it shows that upregulation of Kv1.3 in pathologic B lymphocytes is linked to the oncogenic B-RAF (zeige SNRPE Antikörper) signaling.
Data suggest that C-terminus is necessary for Kv1.3-induced cell proliferation; the mechanism involves accessibility of key docking sites at the C terminus; phosphorylation of Tyr (zeige TYR Antikörper)-447 by MAP kinase (zeige MAPK1 Antikörper) signal cascade appears crucial.
concluded that Kv1.3 may stimulate macrophage migration through the activation of ERK (zeige EPHB2 Antikörper).
The inhibition of Kv1.3 channels might be involved in antiproliferative and proapoptotic effects of the compounds observed in cancer cell lines expressing these channels.
Kv1.3 channels modulate human vascular smooth muscle cells proliferation independently of mTOR (zeige FRAP1 Antikörper) signaling pathway.
actin dynamics regulates the membrane motility of Kv1.3 channels.
promotes B lymphocyte (zeige AKAP17A Antikörper) activation, proliferation and monocyte chemotaxis
Changes in Kv1.3 subcellular distribution upon EGFR (zeige EGFR Antikörper) activation were due to Kv1.3 clathrin-dependent endocytosis, which targets the Kv1.3 channels to the lysosomal degradative pathway.
Kv1.3 channel serves as a negative regulator of phagocytosis in macrophages and can be a potential target in the treatment of macrophage dysfunction
A compensatory upregulation of the potassium channels K2P3.1 (zeige KCNK3 Antikörper) and KV1.3 seems to counterbalance the deletion of K2P5.1 (zeige KCNK5 Antikörper).
JAK2 (zeige JAK2 Antikörper) participates in the signalling, regulating the voltage-gated K(+) channel (zeige KCND3 Antikörper) KCNA3.
Antigenic Stimulation of Kv1.3-Deficient Th Cells Gives Rise to a Population of Foxp3 (zeige FOXP3 Antikörper)-Independent T Cells with Suppressive Properties
A potent and selective peptide blocker of the Kv1.3 channel: prediction from free-energy simulations and experimental confirmation
Inhibition of NMDAR (zeige GRIN1 Antikörper) antagonists on the conductivity of Kv1.3 and KCa3.1 (zeige KCNN4 Antikörper) potassium channels was found.
Potassium channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. This member contains six membrane-spanning domains with a shaker-type repeat in the fourth segment. It belongs to the delayed rectifier class, members of which allow nerve cells to efficiently repolarize following an action potential. It plays an essential role in T-cell proliferation and activation. This gene appears to be intronless and it is clustered together with KCNA2 and KCNA10 genes on chromosome 1.
glibenclamide-sensitive voltage-gated potassium channel
, potassium voltage-gated channel subfamily A member 3
, potassium voltage-gated channel, shaker-related subfamily, member 3
, shaker-like potassium channel subunit Kv1.3B
, potassium channel 3
, type n potassium channel
, voltage-gated K(+) channel HuKIII
, voltage-gated potassium channel protein Kv1.3
, voltage-gated potassium channel subunit Kv1.3
, Voltage-gated potassium channel protein Kv1.3 (RGK5) (RCK3) (KV3)
, potassium voltage gated channel, shaker related subfamily, member 3
, voltage-gated potassium channel subunit Kv3
, Shaker-like voltage-gated potassium channel cKv1.1
, shaker subfamily potassium channel Kv1.3 alpha subunit
, voltage-gated Kv1.3 potassium channel