Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 Proteine (KCNJ1)

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. Zusätzlich bieten wir Ihnen Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 Antikörper (88) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
KCNJ1 3758 P48048
Ratte KCNJ1 KCNJ1 24521 P35560
KCNJ1 56379 O88335
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Showing 7 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,041.49
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,244.78
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Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Hefe Human His tag   50 μg Anmelden zum Anzeigen 8 bis 11 Tage
$341.00
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Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 11 Days
$341.00
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Wheat germ Human GST tag 2 μg Anmelden zum Anzeigen 11 bis 12 Tage
$333.33
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KCNJ1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine) ,
,

Weitere Proteine zu Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) Interaktionspartnern

Cow (Bovine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) Interaktionspartner

  1. The findings support ROMK as the pore-forming subunit of the cytoprotective mitoK(ATP) channel in heart mitochondria.

Human Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) Interaktionspartner

  1. Data suggest underlying pathology for some patients with type II Bartter syndrome is linked to stability of ROMK1 in ERAD pathway; using a yeast expression system, cells can be rescued by wild-type (rat) ROMK1 but not by ROMK1 containing any one of four mutations found in (human) type II Bartter syndrome; mutant ROMKs are significantly less stable than wild-type ROMK. (ERAD = endoplasmic reticulum-associated degradation)

  2. WNK4 (zeige WNK4 Proteine) is a substrate of SFKs and the association of c-Src (zeige SRC Proteine) and PTP-1D (zeige PTPN11 Proteine) with WNK4 (zeige WNK4 Proteine) at Tyr (zeige TYR Proteine)(1092) and Tyr (zeige TYR Proteine)(1143) plays an important role in modulating the inhibitory effect of WNK4 (zeige WNK4 Proteine) on ROMK

  3. knockdown of KCNJ1 in HK-2 (zeige HK2 Proteine) cells promoted cell proliferation. Collectively, these data highlight that KCNJ1, low-expressed in ccRCC and associated with poor prognosis, plays an important role in ccRCC cell growth and metastasis

  4. The association between polymorphisms in KCNJ1, SLC12A1 (zeige SLC12A1 Proteine), and 7 other genes and calcium intake and colorectal neoplasia risk was studied.

  5. A KCNJ1 SNP was associated with increased FG during HCTZ treatment.

  6. Molecular analysis revealed a compound heterozygous mutation in the KCNJ1 gene, consisting of a novel K76E and an already described V315G mutation, both affecting functional domains of the channel protein.

  7. Findings suggest that 11q24 is a susceptible locus for openness, with KCNJ1 as the possible candidate gene.

  8. no mutation in the KCNJ1 gene, among patients suffering from bartter and Gitelman syndromes

  9. PI3K (zeige PIK3CA Proteine)-activating hormones inhibit ROMK by enhancing its endocytosis via a mechanism that involves phosphorylation of WNK1 (zeige WNK1 Proteine) by Akt1 (zeige AKT1 Proteine) and SGK1 (zeige SGK1 Proteine).

  10. THGP (zeige UMOD Proteine) modulation of ROMK function confers a new role of THGP (zeige UMOD Proteine) on renal ion transport and may contribute to salt wasting observed in FJHN/MCKD-2 (zeige UMOD Proteine)/GCKD patients.

Mouse (Murine) Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) Interaktionspartner

  1. The results provide evidence that NHERF1 (zeige SLC9A3R2 Proteine) mediates K(+) current activity through acceleration of the surface expression of ROMK1 K(+) channels in M-1 cells.

  2. ENaC (zeige SCNN1A Proteine) and ROMK channel activity in kidney tubules are inhibited in TgWnk4(pseudoaldosteronism type II) mice. Wnk4 (zeige WNK4 Proteine)(PHAII)-induced inhibition of ENaC (zeige SCNN1A Proteine) and ROMK may contribute to the suppression of K(+) secretion in the tubules.

  3. The differential regulation of ROMK, large-conductance Ca(2 (zeige CA2 Proteine)+)-activated K(+) (BK) channel (zeige KCNMA1 Proteine), BK-alpha and NKCC2 (zeige SLC12A1 Proteine) between female and male mice, at least, were partly mediated via WNK1 (zeige WNK1 Proteine) pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.

  4. Suggest that the hyperkalemia in knock-in mouse with the CUL3 (zeige CUL3 Proteine)(Delta403-459) mutation is not caused by reduced ROMK expression in the distal nephron.

  5. animal knockouts of ROMK1 do not produce Bartter phenotype. ROMK1 is critical in response to high K intake-stimulated K+ secretion in the collecting tubule.

  6. Lovastatin stimulates ROMK1 channels by inducing PI(4,5)P2 synthesis, suggesting that the drug could reduce cyclosporine-induced nephropathy.

  7. ROMK1 protein abundance and activity are down-regulated by SPAK (zeige STK39 Proteine) and OSR1 (zeige OSR1 Proteine)

  8. It was concluded that miR-194 regulates ROMK channel activity by modulating ITSN1 expression thereby enhancing ITSN1/WNK-dependent endocytosis.

  9. THGP (zeige UMOD Proteine) modulation of ROMK function confers a new role of THGP (zeige UMOD Proteine) on renal ion transport and may contribute to salt wasting observed in FJHN/MCKD-2 (zeige UMOD Proteine)/GCKD patients.

  10. hypertension resistance sequence variants inhibit ROMK channel function by different mechanisms

Zebrafish Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) Interaktionspartner

  1. Kcnj1 is expressed in cells associated with osmoregulation and acts as a K+ efflux pathway that is important in maintaining extracellular levels of potassium ion in the developing embryo.

Potassium Inwardly-Rectifying Channel, Subfamily J, Member 1 (KCNJ1) Protein Überblick

Protein Überblick

Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. It is activated by internal ATP and probably plays an important role in potassium homeostasis. The encoded protein has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Mutations in this gene have been associated with antenatal Bartter syndrome, which is characterized by salt wasting, hypokalemic alkalosis, hypercalciuria, and low blood pressure. Multiple transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit KCNJ1

  • potassium voltage-gated channel subfamily J member 1 (KCNJ1)
  • potassium voltage-gated channel subfamily J member 1 L homeolog (kcnj1.L)
  • potassium voltage-gated channel subfamily J member 1 (kcnj1)
  • potassium voltage-gated channel subfamily J member 1 (Kcnj1)
  • potassium inwardly-rectifying channel, subfamily J, member 1 (Kcnj1)
  • potassium channel, inwardly rectifying subfamily J, member 15 L homeolog (kcnj15.L)
  • potassium inwardly-rectifying channel, subfamily J, member 1a, tandem duplicate 1 (kcnj1a.1)
  • Kcnj Protein
  • kcnj1 Protein
  • Kir1.1 Protein
  • MGC68935 Protein
  • ROMK Protein
  • romk1 Protein
  • Romk2 Protein
  • wu:fl37c05 Protein
  • zgc:63534 Protein

Bezeichner auf Proteinebene für KCNJ1

ATP-regulated potassium channel ROM-K , ATP-sensitive inward rectifier potassium channel 1 , inward rectifier K(+) channel Kir1.1 , inwardly rectifying K+ channel , potassium channel, inwardly rectifying subfamily J member 1 , potassium inwardly-rectifying channel, subfamily J, member 1 , potassium inwardly-rectifying channel J1 , ATP-sensitive inward rectifier potassium channel 1-like , K+ channel protein , KAB-1 , Potassium inwardly-rectifying channel subfamily J , kir1.1 , inwardly rectifying potassium channel ROMK-2 , potassium inwardly-rectifying channel, subfamily J, member 15 , LOW QUALITY PROTEIN: ATP-sensitive inward rectifier potassium channel 1

GENE ID SPEZIES
3758 Homo sapiens
428236 Gallus gallus
447262 Xenopus laevis
466846 Pan troglodytes
489285 Canis lupus familiaris
539250 Bos taurus
714848 Macaca mulatta
100072580 Equus caballus
100173141 Pongo abelii
100470569 Ailuropoda melanoleuca
100487609 Xenopus (Silurana) tropicalis
100517668 Sus scrofa
100556003 Anolis carolinensis
100579741 Nomascus leucogenys
24521 Rattus norvegicus
56379 Mus musculus
379692 Xenopus laevis
386933 Danio rerio
100722828 Cavia porcellus
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