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PIGR is a member of the immunoglobulin superfamily. Zusätzlich bieten wir Ihnen Polymeric Immunoglobulin Receptor Proteine (57) und Polymeric Immunoglobulin Receptor Kits (19) und viele weitere Produktgruppen zu diesem Protein an.
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Mouse (Murine) Polyclonal PIGR Primary Antibody für ELISA - ABIN2000383
Kaetzel: Polymeric Ig receptor: defender of the fort or Trojan horse? in Current biology : CB 2001
Zeige alle 2 Referenzen für ABIN2000383
Human Polyclonal PIGR Primary Antibody für WB,IHC (p) - ABIN652495
Orzech, Cohen, Weiss, Aroeti: Interactions between the exocytic and endocytic pathways in polarized Madin-Darby canine kidney cells. in The Journal of biological chemistry 2000
Reduced expression of the polymeric immunoglobulin receptor in pancreatic and periampullary adenocarcinoma signifies tumour progression and poor prognosis.
Crohn disease patients were characterized as having decreased median expression of PIGR, in non-inflamed colonic mucosa. By contrast, Ulcerative colitis patients exhibited decreased expression of PIGR in colon mucosa.
These results demonstrate that SLPI (zeige SLPI Antikörper) down-regulates pIgR expression through the NF-kappaB (zeige NFKB1 Antikörper) signaling pathway by inhibiting degradation of IkappaBbeta (zeige NFKBIB Antikörper) protein.
Report PIGR expression in human fallopian tubes, primary epithelial ovarian tumours and metastases.
the polymeric immunoglobulin receptor (pIgR) is highly expressed by renal cyst-lining cells. pIgR expression is, in part, driven by aberrant STAT6 (zeige STAT6 Antikörper) pathway activation.
Positive expression of pIgR was statistically significantly associated with poor prognosis of patients with colon carcinoma hepatic metastasis.
In conclusion these data suggest that Streptococcus pneumoniae PspC-promoted uptake via the polymeric immunoglobulin receptor of epithelial cells is mediated by both clathrin and caveolin dependent pathway.
Polymeric immunoglobulin receptor expression is correlated with poor prognosis in patients with osteosarcoma.
High PIGR expression independently predicts a decreased risk of recurrence and an improved survival in patients with adenocarcinoma of the upper gastrointestinal tract
pIgR down-regulation in chronic obstructive pulmonary disease correlates with severity. Bronchial epithelium in vitro retains aberrant imprinting for pIgR expression. pIgR down-regulation is linked to TGF-beta (zeige TGFB1 Antikörper)-driven reprogramming of bronchial epithelium.
This study evaluated the production of polymeric immunoglobulin receptor and immunoglobulin A in the salivary glands of cattle.
Increased autoimmune diabetes in Pigr-deficient NOD mice is due to a "Hitchhiking" interval that refines the genetic effect of Idd5.4.
In a mouse intestinal explant model, the heat-inactivated potential probiotic BB6378 increases intestinal pIgR expression in a site-specific manner on the epithelium via MyD88 (zeige MYD88 Antikörper).
pIgR on the blood-brain barrier endothelium may represent a novel pneumococcal adhesion receptor.
Results reveal a novel Yes-EGFR (zeige EGFR Antikörper)-ERK (zeige EPHB2 Antikörper)-FIP5 signalling network for regulation of pIgA (zeige PIGA Antikörper)-pIgR transcytosis.
Blockade of transepithelial transport of dimeric IgA in pIgR knockout mice reduces the degree of protection or cross-protection against viral infection, in parallel with a marked increase in serum IgA concentration and decrease in nasal IgA concentration.
Mice deficient in SIgA have been generated by knocking out the pIgR and assessing their ability to maintain normal mucosal homeostasis and to induce mucosal and systemic immune responses against pathogenic and nonpathogenic stimuli.
Mice that lack expression of the polymeric immunoglobulin receptor have approximately 5-fold more systemic IgA and 6-fold less nasal IgA antibodies than wild-type mice due to defective IgA transport into mucosal tissues.
Data suggest that the pIgR and/or the secretory component are important for the maintenance of epithelial integrity and mucosal homeostasis in the colonic epithelium.
pIgR is essential in intestinal defense against pathogenic microbes with high-level and persistent luminal presence.
This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells\; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.
polymeric immunoglobulin receptor
, polymeric immunoglobulin receptor-like
, poly-Ig receptor
, polymeric IgA receptor
, hepatocellular carcinoma associated protein TB6
, hepatocellular carcinoma-associated protein TB6
, phosphatidylinositol glycan, class R
, poly-IG receptor