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Platelet Factor 4 Proteine (PF4)

PF4 encodes a member of the CXC chemokine family. Zusätzlich bieten wir Ihnen Platelet Factor 4 Antikörper (131) und Platelet Factor 4 Kits (93) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
PF4 5196 P02776
PF4 56744 Q9Z126
PF4 360918 P06765
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Showing 10 out of 74 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
605,65 €
Details
HOST_Escherichia coli (E. coli) Human Unkonjugiert 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
587,50 €
Details
HOST_Escherichia coli (E. coli) Human His tag 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
395,77 €
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 26 bis 31 Tage
4.115,41 €
Details
HOST_Escherichia coli (E. coli) Maus Unkonjugiert   10 μg Anmelden zum Anzeigen 6 bis 8 Tage
129,41 €
Details
HOST_Escherichia coli (E. coli) Ratte His tag,GST tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
533,33 €
Details
HOST_Escherichia coli (E. coli) Maus His tag 100 μg Anmelden zum Anzeigen 13 bis 17 Tage
685,71 €
Details
HOST_Escherichia coli (E. coli) Maus Unkonjugiert   50 μg Anmelden zum Anzeigen 6 bis 8 Tage
721,70 €
Details
HOST_Human Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
214,29 €
Details

PF4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Mouse (Murine)
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Rat (Rattus) ,
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Am meisten referenzierte Platelet Factor 4 Proteine

  1. Human PF4 Protein expressed in Escherichia coli (E. coli) - ABIN2666881 : Lasagni, Francalanci, Annunziato, Lazzeri, Giannini, Cosmi, Sagrinati, Mazzinghi, Orlando, Maggi, Marra, Romagnani, Serio, Romagnani: An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4. in The Journal of experimental medicine 2003 (PubMed)
    Zeige alle 10 Referenzen für ABIN2666881

  2. Mouse (Murine) PF4 Protein expressed in Escherichia coli (E. coli) - ABIN2666923 : Maione, Gray, Petro, Hunt, Donner, Bauer, Carson, Sharpe: Inhibition of angiogenesis by recombinant human platelet factor-4 and related peptides. in Science (New York, N.Y.) 1990 (PubMed)
    Zeige alle 10 Referenzen für ABIN2666923

  3. Human PF4 Protein expressed in Escherichia coli (E. coli) - ABIN2003519 : ODonovan, Galvin, Morgan: Physical mapping of the CXC chemokine locus on human chromosome 4. in Cytogenetics and cell genetics 1999 (PubMed)

Weitere Proteine zu Platelet Factor 4 (PF4) Interaktionspartnern

Human Platelet Factor 4 (PF4) Interaktionspartner

  1. CXCL4 plays an important role in pancreatic inflammation

  2. Data suggest that serum haptoglobin, fetuin-A, platelet factor-4, hs-CRP (high sensitive-C-reactive protein), SAP (serum amyloid P), AGP (alpha1-acid glycoprotein) levels of adolescents with metabolic syndrome are significantly higher than those of controls subjects.

  3. The hitherto unknown association of increased serum CXCL4 with features of microvascular impairment in primary Sjogren's syndrome, along with the negative association with features of lymphocytic response suggest clarifying the possible implication of this chemokine (zeige CCL1 Proteine) in primary Sjogren's syndrome pathogenesis in larger studies.

  4. serum concentration of CXCL4 was significantly increased in patients with Chronic Liver Allograft Dysfunction (CLAD); CXCL4 mRNA was significantly increased in subjects with CLAD versus individuals without CLAD

  5. Plasma levels of CXCL4 are associated with tumour vascularity.

  6. Data suggest that, in patients with hypothyroid autoimmune thyroiditis, PF4/CXCL4 serum levels are significantly lower in those with subclinical hypothyroidism than in euthyroid control subjects.

  7. Expression of CXCL4 and aquaporin 3 (zeige AQP3 Proteine) and 10 mRNAs in middle ear effusion is associated with the pathophysiology of otitis media with effusion.

  8. PF4 changed its structure upon binding to polyP in a similar way as seen in PF4/heparin complexes. PF4/polyP complexes exposed neoepitopes to which human anti-PF4/heparin antibodies bound.

  9. PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.

  10. A subset of heparin-treated patients produce subthreshold levels of platelet-activating anti-PF4/heparin antibodies that do not cause heparin-induced thrombocytopenia.

Mouse (Murine) Platelet Factor 4 (PF4) Interaktionspartner

  1. Platelet-derived CXCL7 (zeige PPBP Proteine) and CXCL4 contribute to the pathogenesis of acute lung injury.

  2. CXCL4 plays an important role in pancreatic inflammation

  3. Platelet secretion of CXCL4 is Rac1-dependent and regulates neutrophil infiltration and tissue damage in septic lung damage

  4. PF4 has a complex intramedullary life cycle with important implications in megakaryopoiesis and hematopoietic stem cell replication not seen with other tested alpha granule proteins.

  5. Heparin enhances antigen uptake and activation of the initial steps in the cellular immune response to PF4-containing complexes.

  6. Data indicate that platelet factor 4 (PF4) is involved directly in liver innate immune response against ischaemia-reperfusion injury (IRI) by regulating Th17 cell differentiation.

  7. CXCL4 regulates hematopoietic stem cell cell cycle activity.

  8. Platelet factor 4 has a role in regulating Th17 differentiation and cardiac allograft rejection

  9. Histones regulate activated protein C (zeige PROC Proteine) formation in a manner similar to PF4 and suggest heparinoids may be benificial in sepsis.

  10. PF4 drives a vascular smooth muscle inflammatory phenotype including a decline in differentiation markers, increased cytokine production, and cell proliferation.

Platelet Factor 4 (PF4) Protein Überblick

Protein Überblick

This gene encodes a member of the CXC chemokine family. This chemokine is released from the alpha granules of activated platelets in the form of a homotetramer which has high affinity for heparin and is involved in platelet aggregation. This protein is chemotactic for numerous other cell type and also functions as an inhibitor of hematopoiesis, angiogenesis and T-cell function.

Genbezeichner und Symbole assoziert mit Platelet Factor 4 Proteine (PF4)

  • platelet factor 4 (PF4)
  • platelet factor 4 (Pf4)
  • Cxcl4 Protein
  • PF-4 Protein
  • Pf4a Protein
  • RATPF4A Protein
  • Scyb4 Protein

Bezeichner auf Proteinebene für Platelet Factor 4 Proteine (PF4)

platelet factor 4 (chemokine (C-X-C motif) ligand 4) , C-X-C motif chemokine 4 , chemokine (C-X-C motif) ligand 4 , iroplact , oncostatin-A , PF-4

GENE ID SPEZIES
703451 Macaca mulatta
740477 Pan troglodytes
5196 Homo sapiens
56744 Mus musculus
360918 Rattus norvegicus
507790 Bos taurus
101104401 Ovis aries
Ausgewählte Anbieter für Platelet Factor 4 Proteine (PF4)
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