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PXK binds to the Na,K-ATPase beta-1 (ATP1B1\; MIM 182330) and beta-3 (ATP1B3\; MIM 601867) subunits and modulates both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005 [PubMed 16135750]).[supplied by OMIM, Mar 2008].. Zusätzlich bieten wir Ihnen PXK Proteine (7) und PXK Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
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Two of these kinases that were classified as resistors were PX domain-containing serine/threonine kinase (PXK) and AP2-associated kinase 1 (AAK1), which promote receptor endocytosis and may enable cells to resist TRAIL-induced apoptosis
genetic association study in Han population in China: Data suggest an SNP in PXK [rs2176082(C/T); but not rs6445975(G/T)] is associated with recurrent pregnancy loss; SNPs in KIAA0319L (zeige KIAA0319L Antikörper) [rs2275247(A/G)] or JAZF1 (zeige JAZF1 Antikörper) [rs1635852(C/T)] are not associated.
Results confirm the genetic association of the locus 3p14.3 with systemic lupus erythematosus in Europeans and point to the ABHD6 (zeige ABHD6 Antikörper) and not PXK, as the major susceptibility gene in the region.
study determined that the previously described systemic lupus erythematosus susceptibility loci PXK (P = 3.27 x 10(-11), OR = 1.20) and JAZF1 (zeige JAZF1 Antikörper) (P = 1.11 x 10(-8), OR = 1.13) are shared with systemic sclerosis
The rs6445975 polymorphism of PXK and the rs2304256 polymorphism of tyrosine kinase 2 (zeige TYK2 Antikörper) are associated with the development of systemic lupus erythematosus in Europeans
The association of PXK rs6445975 with systemic lupus erythematosus that was previously observed in Caucasians was not replicated in Koreans or in Hong Kong Chinese.
These results indicate that PXK plays a critical role in epidermal growth factor receptor (zeige EGFR Antikörper) trafficking through modulating ligand-induced ubiquitination of the receptor.
MONaKA modulates brain Na,K-ATPase (zeige ATP1A1 Antikörper) by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission [MONaKA]
study presents four new regions having genetic associations with systemic lupus erythematosus in women of European descent: ITGAM (zeige ITGAM Antikörper), KIAA1542, PXK and rs10798269
MONaKA modulates brain Na,K-ATPase (zeige ATP1A1 Antikörper) by binding tightly to its beta1 and beta3 subunits, and may thereby participate in the regulation of electrical excitability and synaptic transmission.
PXK binds to the Na,K-ATPase beta-1 (ATP1B1\; MIM 182330) and beta-3 (ATP1B3\; MIM 601867) subunits and modulates both Na,K-ATPase enzymatic and ion pump activities (Mao et al., 2005
PX domain-containing protein kinase-like protein
, PX ser/thr kinase v2
, PX serine/threonine kinase
, modulator of Na,K-ATPase long form
, modulator of Na,K-ATPase