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The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Zusätzlich bieten wir Ihnen POU2F1 Antikörper (139) und POU2F1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.
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Children with certain OCT1 genotypes have higher risk for respiratory depression and nausea and vomiting, postoperatively, following morphine administration.
High POU2F1 expression is associated with liver cancer.
THE results of this investigation demonstrate that genetic polymorphisms in the hepatic uptake transporter OCT1 affect the pharmacokinetics and efficacy of tramadol.
Hepatic distribution of metformin was significantly reduced after oral administration in individuals with genetic polymorphisms in OCT1.
hOCT1 mRNA expression may serve as a clinical biomarker of response to imatinib and could be useful to predict Imatinib mesylate therapy outcome of chronic myeloid leukemia (zeige BCL11A ELISA Kits) patients
ABCB1 (zeige ABCB1 ELISA Kits) and OCT1 mRNA expressions may present biological relevance to identify responder and non-responder patients to imatinib treatment
Our study demonstrates that the existence of Oct-1 isoforms which vary in length and sequence at the N-terminus of the protein, also contributes in surprising diversity of Oct-1 functions in transcription regulation.
HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region
OCT1 transported sumatriptan with high capacity and sumatriptan uptake into human hepatocytes was strongly inhibited by the OCT1 inhibitor MPP(+)
Neither AUC0-150min, ktr, CL, nor VD were associated with genetic variants in OCT1, ABCB1 (zeige ABCB1 ELISA Kits), and UGT2B7 (zeige UGT2B7 ELISA Kits) (all P>0.05).
identified Oct-1 (POU2f1), a POU transcription factor (zeige POU2F3 ELISA Kits), as a downstream target of Notch (zeige NOTCH1 ELISA Kits) signaling by microarray based screen
At low oxLDL levels LOX-1 (zeige OLR1 ELISA Kits) activates the protective Oct-1/SIRT1 (zeige SIRT1 ELISA Kits) pathway, while at higher levels of the lipoprotein switches to the thrombogenic ERK1/2 (zeige MAPK1/3 ELISA Kits) pathway.
Study conclude that pentamidine interacts with multiple transporters, is taken into brain endothelial cells by OCT1 transporter and is extruded into the blood by ATP-dependent mechanisms. These interactions along with the predominant presence of OCT1 in the luminal membrane of the BBB (zeige ALMS1 ELISA Kits) contribute to the limited entry of pentamidine into the brain.
These results suggest that Oct-1 and GATA-3 (zeige GATA3 ELISA Kits)/Oct-2 direct Th2 cytokine gene expression in a cooperative manner.
Findings indicate octamer transcription factor-1 (zeige HNF1A ELISA Kits) (Oct1) and Oct binding factor 1 (zeige POU2AF1 ELISA Kits) protein (OCA-B (zeige POU2AF1 ELISA Kits)) as central mediators of CD4 (zeige CD4 ELISA Kits)(+) T cell memory.
levels of microRNA-451 (miR (zeige MLXIP ELISA Kits)-451) are negatively regulated through the phosphorylation and inactivation of its direct transcriptional activator OCT1 by 5' AMP-activated protein kinase (zeige PRKAA2 ELISA Kits)
Oct1 mRNA expression was decreased in mice with both ob/ob and methionine/choline deficiency models of nonalcoholic steatohepatitis.
OCT1 is a driver of synbindin (zeige TRAPPC4 ELISA Kits)-mediated ERK (zeige EPHB2 ELISA Kits) signalling and a promising marker for the prognosis and molecular subtyping of gastric cancer.
studies implicate OCT1 as well as metformin in thiamine disposition, suggesting an intriguing and parallel mechanism for metformin and its major hepatic transporter in metabolic function.
Th17 lineage differentiation is restrained by the Th2 locus via interchromosomal associations organized by Oct-1 and CTCF (zeige CTCF ELISA Kits).
inhibition of the DNA binding activity of transcriptional repressor OCT-1 is a mechanism by which ethanol up-regulates Slc711 expression.
The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993
POU class 2 homeobox 1
, POU domain, class 2, transcription factor 1
, Octamer-binding transcription factor-1
, octamer-binding protein 1
, octamer-binding transcription factor 1
, octamer-binding protein (Oct-1)
, octamer binding protein 1
, maternal transcription factor
, ubiquitous transcription factor