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Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Zusätzlich bieten wir Ihnen Organic Solute Transporter alpha Antikörper (23) und Organic Solute Transporter alpha Proteine (3) und viele weitere Produktgruppen zu diesem Protein an.
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SLC51A expression is significantly upregulated in human masticatory mucosa during wound healing
Hepatic OSTalpha-OSTbeta (zeige OSTBETA ELISA Kits) expression is induced by hypoxia.
Ostbeta (zeige OSTBETA ELISA Kits) is required for both proper trafficking of Ostalpha and formation of the functional transport unit, and identify specific residues of Ostbeta (zeige OSTBETA ELISA Kits) critical for these processes.
The present report summarizes the evidence for a pleiotropic role of Ostalpha-Ostbeta (zeige OSTBETA ELISA Kits) in different tissues.
OSTalpha has roles in biological transport and is widely expressed in human tissues
overexpression of hu (zeige OSTBETA ELISA Kits)man OSTalpha and OSTbeta facilitated the uptake of conjugated chenodeoxycholate (zeige NR1H4 ELISA Kits) and the activation of FXR target genes
OSTalpha/OSTbeta (zeige OSTBETA ELISA Kits) expression is induced by bile acids through ligand-dependent transactivation of both OST (zeige DDOST ELISA Kits) genes by the nuclear bile acid receptor (zeige NR1H4 ELISA Kits)/farnesoid X receptor (FXR (zeige NR1H4 ELISA Kits)).
the selective localization of OSTalpha and OSTbeta (zeige OSTBETA ELISA Kits) to the basolateral plasma membrane of epithelial cells responsible for bile acid and sterol reabsorption.
These results indicate that expression of Ostalpha and Ostbeta (zeige OSTBETA ELISA Kits) are highly regulated in response to cholestasis and that this response is dependent on the FXR bile acid receptor (zeige NR1H4 ELISA Kits).
Demonstrate association of OST-alpha and OST-beta (zeige OSTBETA ELISA Kits) to determine trafficking to plasma membrane and activity.
Data suggest that transport of bile acid taurocholate is retained when OstB (organic solute transporter beta subunit (zeige OSTBETA ELISA Kits)) is truncated to contain only the transmembrane domain with 15 additional residues on each side and co-expressed with intact OstA; shorter fragments of OstB (zeige OSTBETA ELISA Kits) are inactive.
These findings indicate that loss of OSTalpha protects against age-related weight gain and insulin (zeige INS ELISA Kits) resistance.
Ileal FGF15 expression was directly correlated with plasma cholesterol levels and aortic cholesterol content. In contrast, plasma and hepatic cholesterol levels and atherosclerosis development were not reduced in apoE (zeige APOE ELISA Kits)(-/-) mice deficient in Ostalpha.
Total ileal FGF15 expression was elevated almost 20-fold in Ostalpha(-/-) mice as a result of increased villus epithelial cell number and ileocyte FGF15 protein expression
Inactivation of FXR (zeige NR1H4 ELISA Kits) largely unmasked the bile acid malabsorption phenotype and corrected the bile acid homeostasis defect in Ostalpha null mice.
Ostalpha-deficient mice efficiently eliminate excess bile acids via the feces.
OSTalpha is localized to steroidogenic cells of the brain and adrenal gland, and it modulates DHEA/DHEAS (zeige SULT2A1 ELISA Kits) homeostasis
These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine.
Co-expression of mouse Ostalpha-Ostbeta (zeige OSTBETA ELISA Kits), but not the individual subunits, stimulated Na(+)-independent bile acid uptake and the apical-to-basolateral transport of taurocholate
OSTalpha and OSTbeta (zeige OSTBETA ELISA Kits) mRNA levels were induced in the adrenals and kidneys of wild-type, but not FXR (zeige NR1H4 ELISA Kits)-/-, mice
Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood. Efficiently transports the major species of bile acids (By similarity).
organic solute transporter alpha
, organic solute transporter subunit alpha
, organic solute transporter, alpha subunit
, solute carrier family 51 subunit alpha