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Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis (By similarity).. Zusätzlich bieten wir Ihnen OIP5 Antikörper (18) und viele weitere Produktgruppen zu diesem Protein an.
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These findings suggest that OIP5 may be involved in hepatocellular carcinoma (HCC (zeige FAM126A Proteine)) growth and metastasis and that miR (zeige MLXIP Proteine)-15b-5p inhibits OIP5-mediated oncogenic signaling in HCC (zeige FAM126A Proteine).
the Mis18 complex contains dual CENP-C recognition motifs that are combinatorially required to generate robust centromeric localization that leads to CENP-A (zeige CENPA Proteine) deposition
OIP5 over-expression inhibited hsa (zeige CD24 Proteine)-miR (zeige MLXIP Proteine)-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1 (zeige NOTCH1 Proteine), which was a core oncogene (zeige RAB1A Proteine) in promoting breast cancer progression.
Stable binding of Mis18alpha (zeige MIS18A Proteine)-Mis18beta heterotetramer to centromeres in telophase licenses them for CENP-A (zeige CENPA Proteine) deposition.
Over-expression of OIP5 was observed in breast tumors.
Mis18beta binds with and specifies the centromere localization of HJURP (zeige HJURP Proteine).
this study showed betaTrCP (zeige BTRC Proteine)-mediated regulation of Mis18beta stability is a mechanism to restrict centromere function of Mis18 complex from late mitosis to early G1 phase.
expression of AURKC (zeige AURKC Proteine), OIP5, PIWIL2 and TAF7L (zeige TAF7L Proteine) differed between patients with Acute myeloid leukemia (zeige BCL11A Proteine), myelodysplastic syndrome and healthy controls in a gender-dependent manner
OIP5 expression was significantly associated with poor prognosis of lung and esophageal cancer patients
These results indicate that knockdown of OIP5 may induce apoptosis in cancer cells.
Increase of Oip5 may associate with development of obesity.
Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis (By similarity).
, Opa interacting protein 5
, LAP2alpha interactor-25
, MIS18 kinetochore protein homolog B
, cancer/testis antigen 86
, opa-interacting protein 5
, opa-interacting protein 5 homolog