Nicotinamide Nucleotide Adenylyltransferase 1 Proteine (NMNAT1)

NMNAT1 encodes an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. Zusätzlich bieten wir Ihnen NMNAT1 Antikörper (81) und NMNAT1 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NMNAT1 64802 Q9HAN9
NMNAT1 66454 Q9EPA7
Ratte NMNAT1 NMNAT1 298653  
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Showing 10 out of 16 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,331.68
Details
Baculovirus infected Insect Cells Human His tag 10 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$319.00
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Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$795.00
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Insektenzellen Human His tag   20 μg Anmelden zum Anzeigen 2 bis 3 Tage
$227.63
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Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$405.71
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 20 Days
$785.40
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,737.17
Details
Hefe Yeast His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,111.17
Details

NMNAT1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , ,
, ,
Mouse (Murine)

Weitere Proteine zu Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1) Interaktionspartnern

Human Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1) Interaktionspartner

  1. Hidden Genetic Variation in LCA9-Associated Congenital Blindness Explained by 5'UTR Mutations and Copy-Number Variations of NMNAT1.

  2. We confirmed a diagnosis of NMNAT1-associated Leber congenital amaurosis in two siblings through identification of the mutation (c.25G>A [p. Val9Met]) in a homozygous state.

  3. NMNAT1, which encodes the nicotinamide mononucleotide adenylyltransferase 1, has been recently identified to be one of the LCA (zeige CLTA Proteine)-causing genes. Our results expanded the spectrum of mutations in NMNAT1

  4. To study how mutations affect NMNAT1 function and ultimately lead to a retinal degeneration phenotype, we performed detailed analysis of Leber congenital amaurosis 9-associated NMNAT1 mutants.

  5. theNMNAT1 p.Glu257Lys variant is a hypomorphic variant that almost without exception causes leber congenital amaurosis (LCA (zeige CLTA Proteine)) in combination with more severe NMNAT1 variants.

  6. The aim of this study was to determine the occurrence and frequency of NMNAT1 mutations and associated phenotypes in different types of inherited retinal dystrophies.

  7. Data found pathogenic DNA variants in the genes RP1 (zeige STK19 Proteine), USH2A, CNGB3 (zeige CNGB3 Proteine), NMNAT1, CHM (zeige CHM Proteine), and ABCA4 (zeige ABCA4 Proteine), responsible for retinitis pigmentosa, Usher syndrome, achromatopsia, Leber congenital amaurosis, choroideremia (zeige CHM Proteine), or recessive Stargardt/cone-rod dystrophy cases.

  8. NMNAT1 deletion in tumors may contribute to transformation by increasing ribosomal RNA synthesis.

  9. mutations in nicotinamide nucleotide adenylyltransferase 1(NMNAT1) cause Leber congenital amaurosis

  10. Mutations in NMNAT1 cause Leber congenital amaurosis with early-onset severe macular and optic atrophy.

Mouse (Murine) Nicotinamide Nucleotide Adenylyltransferase 1 (NMNAT1) Interaktionspartner

  1. NMNAT1 overexpression enhanced AMPK (zeige PRKAA1 Proteine) activity in oxygen-glucose deprivation treated cortical neurons

  2. An increased level of Nmnat protein in hiw mutants is both required and sufficient to inhibit axonal degeneration.

  3. Overexpression of Nmnat1 in the cytoplasm and axons of RGCs robustly protected against both ischemic and glaucomatous loss of RGC axonal integrity, as well as loss of RGC soma.

  4. Findings reveal a novel role for NMNAT1 in the morphogenesis of developing cortical neurons, which indicate that the loss of function of NMNAT1 may contribute to different neurodegenerative disorders in central nervous system.

  5. Nicotinamide mononucleotide adenylyl transferase 1 protects against acute neurodegeneration in developing CNS by inhibiting excitotoxic-necrotic cell death.

  6. NMNAT1 is indispensable for the normal development of the embryo. Decreased NMNAT1 activity in heterozygous null mice does not affect the rate of Wallerian degeneration, suggesting that endogenous NMNAT1 does not have a primary role in axon maintenance.

  7. nicotinamide mononucleotide adenylyltransferase (Nmnat) protein transduction into transected axons blocks axonal degeneration

  8. Through NAMPT (zeige NAMPT Proteine) activity, visfatin (zeige NAMPT Proteine) contributes to vascular inflammation, causing atherothrombotic diseases linked to metabolic disorders.

  9. demonstrated that increased Nmnat activity is responsible for the axon-sparing activity of the Wlds protein; also demonstrated that SIRT1 (zeige SIRT1 Proteine) is the downstream effector of increased Nmnat activity that leads to

  10. Nmnat1 is significantly weaker than Wld(S) at protecting axons against traumatic or toxic injury in vitro, and has no detectable effect in vivo

NMNAT1 Protein Überblick

Protein Überblick

This gene encodes an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. The encoded protein is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown the encoded protein can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecule. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14 and 15.

Genbezeichner und Symbole assoziert mit NMNAT1

  • nicotinamide mononucleotide adenylyltransferase 1 (CpipJ_CPIJ015320)
  • nicotinamide mononucleotide adenylyltransferase 1 (PTRG_06486)
  • nicotinamide nucleotide adenylyltransferase 1 (nmnat1)
  • nicotinamide nucleotide adenylyltransferase 1 (NMNAT1)
  • nicotinamide nucleotide adenylyltransferase 1 (Nmnat1)
  • 2610529L11Rik Protein
  • 5730441G13Rik Protein
  • D4Cole1e Protein
  • id:ibd5068 Protein
  • im:7144541 Protein
  • LCA9 Protein
  • nmnat Protein
  • PNAT1 Protein
  • zgc:110243 Protein

Bezeichner auf Proteinebene für NMNAT1

nicotinamide mononucleotide adenylyltransferase 1 , Nicotinamide mononucleotide adenylyltransferase 1 , NMN adenylyltransferase 1 , NaMN adenylyltransferase 1 , nicotinate-nucleotide adenylyltransferase 1 , pyridine nucleotide adenylyltransferase 1 , naMN adenylyltransferase 1 , NAD(+) diphosphorylase , NAD(+) pyrophosphorylase , deamido-NAD(+) diphosphorylase , deamido-NAD(+) pyrophosphorylase , nicotinamide mononucleotide adenylyl transferase , nicotinamide/nicotinate mononucleotide adenylyltransferase 1 , nicotinamide mononucleotide adenylyl transferase 1

GENE ID SPEZIES
6048336 Culex quinquefasciatus
6344745 Pyrenophora tritici-repentis Pt-1C-BFP
100194756 Salmo salar
550322 Danio rerio
419446 Gallus gallus
64802 Homo sapiens
479601 Canis lupus familiaris
522863 Bos taurus
66454 Mus musculus
298653 Rattus norvegicus
Ausgewählte Anbieter für NMNAT1 Proteine (NMNAT1)
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