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NRN1 is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. Zusätzlich bieten wir Ihnen Neuritin 1 Kits (21) und Neuritin 1 Proteine (18) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal NRN1 Primary Antibody für IHC, ELISA - ABIN1002892
Li, Sheng: Some assembly required: the development of neuronal synapses. in Nature reviews. Molecular cell biology 2003
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Human Polyclonal NRN1 Primary Antibody für CyTOF, FACS - ABIN4900058
Choi, Lee, Ryu, Kim, Jeong, Woo, Lee, Hyun, Hahn, Kim, Kim: Neuritin attenuates cognitive function impairments in tg2576 mouse model of Alzheimer's disease. in PLoS ONE 2014
Show all 3 Pubmed References
Human Polyclonal NRN1 Primary Antibody für IF (p), IHC (p) - ABIN740655
Li, Wei, Bai, Li, Huang, Lin, Hou, Deng, Zhou, Zhang, Chen: MicroRNA-574 is involved in cognitive impairment in 5-month-old APP/PS1 mice through regulation of neuritin. in Brain research 2015
results suggest that DTNBP1 (zeige DTNBP1 Antikörper) and NRN1 genes show a joint effect on the risk for schizophrenia spectrum disorders. Although the precise mechanism underlying this effect is unclear, the fact that these genes have been involved in synaptic maturation, connectivity and glutamate (zeige GRIN1 Antikörper) signalling suggests that our findings could be of value as a link to the schizophrenia aetiology.
NRN1 is associated with depressive symptoms and executive function in a non-clinical sample. Our results also suggest that the role of NRN1 seems to be modulated by BDNF (zeige BDNF Antikörper).
On analysis of the expression of NRN1 in SMA (zeige SMN1 Antikörper) patients for the first time, NRN1 could be a potential modifier gene
Ca(2 (zeige CA2 Antikörper)+)/calcineurin (CaN)/nuclear factor of activated T-cells (NFAT (zeige NFATC1 Antikörper)) c4 axis is required for neuritin-induced Kv4.2 (zeige KCND2 Antikörper) transcriptional expression and potentiation of IA densities in cerebellum granule neurons.
(i) NRN1 variability is a shared risk factor for both schizophrenia-spectrum disorders (SSD) and bipolar disorders (BPD (zeige MOD(MDG4) Antikörper)), (ii) NRN1 may have a selective impact on age at onset and intelligence in SSD.
Data indicate that neuritin not only plays an important role in the nervous system but also has an effect on the migration, senescence, proliferation, and viability of stem cells
Neuritin is reduced in the brains of Alzheimer's disease (AD) patients.
MiR (zeige MLXIP Antikörper)-204 promotes apoptosis in oxidative stress-induced (zeige SQSTM1 Antikörper) rat Schwann cells by suppressing neuritin expression
we found neuritin is overexpressed in astrocytoma, which may be an important factor in tumorigenesis and progression of astrocytoma
Data show that SMN (zeige STMN1 Antikörper) and HuD (zeige ELAVL4 Antikörper) form a complex in spinal motor axons, and that both interact with cpg15 mRNA in neurons.
Following cerebral ischemia there is an increase in cpg15 expression in hippocampal astrocytes.
Neuritin prevents extremely low-frequency electromagnetic fields-exposure-induced memory deficit by increasing the hippocampal spine density.
Neuritin can normalize neural deficits of Alzheimer's disease.
Neuritin restors the reduction in dendritic spine density and the maturity of individual spines in primary hippocampal neuron cultures from a Alzheimer disease mouse model.
Activity-dependent development of the visual system requires synapse stabilization and maturation via CPG15.
CPG15 acts to stabilize active synapses on dendritic spines, resulting in selective spine and arbor stabilization and synaptic maturation, and that synapse stabilization mediated by CPG15 is critical for efficient learning
Cpg15 is an immediate-early (zeige JUN Antikörper) gene induced by Ca(2 (zeige CA2 Antikörper)+) influx through NMDA receptors and L-type voltage-sensitive calcium channels. It requires convergent activation of the CaM kinase (zeige CAMK2 Antikörper) and MAP kinase (zeige MAPK1 Antikörper) pathways.
Regulation of cpg15 expression during single whisker experience in the barrel cortex of adult mice.
This gene is expressed in postmitotic-differentiating neurons of the developmental nervous system and neuronal structures associated with plasticity in the adult. The expression of this gene can be induced by neural activity and neurotrophins. The encoded protein contains a consensus cleavage signal found in glycosylphoshatidylinositol (GPI)-anchored proteins. In vitro assays demonstrated that this protein promotes neurite outgrowth and arborization, suggesting its role in promoting neuritogenesis.
, neuritin 1
, candidate plasticity gene 15 protein
, candidate plasticity-related gene 15