N-Myc Downstream Regulated 1 Proteine (NDRG1)

NDRG1 is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. Zusätzlich bieten wir Ihnen N-Myc Downstream Regulated 1 Antikörper (174) und N-Myc Downstream Regulated 1 Kits (9) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NDRG1 10397 Q92597
NDRG1 17988 Q62433
Ratte NDRG1 NDRG1 299923 Q6JE36
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Showing 10 out of 18 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 18 bis 20 Tage
312,50 €
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Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 6 bis 8 Tage
366,67 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 11 bis 15 Tage
230,48 €
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Hefe Arabidopsis thaliana His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
2.240,16 €
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HOST_Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 8 bis 9 Tage
523,81 €
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Escherichia coli (E. coli) Human His tag   10 μg Anmelden zum Anzeigen 13 bis 15 Tage
285,71 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
Details

NDRG1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Weitere Proteine zu N-Myc Downstream Regulated 1 (NDRG1) Interaktionspartnern

Human N-Myc Downstream Regulated 1 (NDRG1) Interaktionspartner

  1. we demonstrated that the novel molecule of cell migration and invasion, caveolin-1, has direct interaction with NDRG1 in human colorectal cancer cells

  2. strong NDRG1 expression in ciliated epithelial cells in nasal tissues sampled from patients with chronic rhinosinusitis. NDRG1 gene knockdown decreased the transepithelial electrical resistance and increased the dextran permeability. NDRG1 knockdown disrupted tight junctions of airway epithelial cells. NDRG1 knockdown significantly decreased only claudin-9 (zeige CLDN9 Proteine) expression, but did not decrease other claudin family molecules.

  3. Study elucidates a mechanism of NDRG1-regulated Wnt (zeige WNT2 Proteine) pathway activation and EMT (zeige ITK Proteine) via affecting TLE2 (zeige TLE2 Proteine) and beta-catenin (zeige CTNNB1 Proteine) expression in esophageal cancer cells.

  4. NDRG1 prevented the degradation of c-Myc (zeige MYC Proteine) through Skp2-mediated ubiquitination in tumor cells. NDRG1 directly interacted with Skp2, and decreased phosphorylation of Skp2 through inactivation of CDK2 (zeige CDK2 Proteine).

  5. Data suggest that NDRG1 attenuates oncogenic signaling by inhibiting formation of EGFR (zeige EGFR Proteine)/HER2 (zeige ERBB2 Proteine) and HER2 (zeige ERBB2 Proteine)/HER3 (zeige ERBB3 Proteine) heterodimers and by down-regulating EGFR (zeige EGFR Proteine) via a mechanism involving its degradation. (NDRG1 = N-myc downstream regulated gene 1 protein; EGFR (zeige EGFR Proteine) = epidermal growth factor receptor (zeige EGFR Proteine); HER = human epidermal growth factor receptor (zeige EGFR Proteine)) [REVIEW]

  6. NDR1 interacts with TRAF3 and interferes with the association of TRAF3 and IL-17R, resulting in increased formation of the activation complex IL-17R-Act1, which is required for the downstream signaling and production of pro-inflammatory factors

  7. NDRG1 overexpression leads to reduced tumor growth and angiogenesis in experimental glioma via upregulation of TNFSF15. In NDRG1 overexpressing glioma antiangiogenic treatment does not yield a therapeutic response.

  8. The current study is the first to elucidate a unique facet of the potent tumor/metastasis suppressor NDRG1 in the regulation of pancreatic ductal adenocarcinoma (PDAC)glycolysis, leading to important insights into the mechanism by which NDRG1 exert inhibitory function in PDAC.

  9. The mean nerve NDRG1 expression score was 5.4.

  10. Hereditary motor and sensory neuropathy-type Lom in 12 Czech patients, carrying NDRG1 mutation and one unusual case due to uniparental isodisomy of chromosome 8 has been reported.

Mouse (Murine) N-Myc Downstream Regulated 1 (NDRG1) Interaktionspartner

  1. NDR1 interacts with TRAF3 and interferes with the association of TRAF3 and IL-17R, resulting in increased formation of the activation complex IL-17R-Act1, which is required for the downstream signaling and production of pro-inflammatory factors

  2. NDR1 (zeige STK38 Proteine) kinase, activated by the Rap1 (zeige TERF2IP Proteine) signaling cascade through RAPL (zeige RASSF5 Proteine) and Mst1 (zeige MST1 Proteine)/Mst2 (zeige STK3 Proteine), associated with and recruited kindlin-3 (zeige FERMT3 Proteine) to the immunological synapses, which was required for high-affinity LFA-1 (zeige ITGAL Proteine)/ICAM-1 (zeige ICAM1 Proteine) binding.

  3. Snell, GHKRO, and PAPPA (zeige PAPPA Proteine)-KO mice express high levels of two proteins involved in DNA repair, O-6-methylguanine-DNA methyltransferase (MGMT (zeige MGMT Proteine)) and N-myc downstream-regulated gene 1 (NDRG1).

  4. NDRG1 deficiency attenuates the differentiation of macrophage lineage cells, suppressing bone remodeling and inflammatory angiogenesis. This study strongly suggests the crucial role of NDRG1 in differentiation process for macrophages.

  5. Using double knockout of NDR1 (zeige STK38 Proteine) and 2 shows that NDRs acted downstream of MST1 (zeige MST1 Proteine) to mediate the egress of mature thymocytes from the thymus, as well as the interstitial migration of naive T cells within popliteal lymph nodes.

  6. Ndrg1 is phosphorylated and degraded by CD28 (zeige CD28 Proteine) signalling in a proteasome-dependent manner.

  7. Ndr1 (zeige STK38 Proteine)/2-double null embryos show defects in somitogenesis and cardiac looping, which reveals their essential functions and shows that the NDR (zeige STK38 Proteine) kinases are critically required during the early phase of organogenesis

  8. Rassf5 (zeige RASSF5 Proteine) and Ndr1 (zeige STK38 Proteine) or Ndr2 (zeige STK38L Proteine) kinases regulate neuronal polarity through Par3 (zeige F2RL2 Proteine) phosphorylation.

  9. NDRG1 promotes fetal growth and regulates the metabolic response to intrauterine hypoxic injury in a sexually dichotomous manner

  10. early growth response 1 (zeige EGR1 Proteine), a transcription factor that binds to the NDRG1 promoter, was mediated in the NDRG1 expression regulation by PKD2 (zeige PKD2 Proteine).

Arabidopsis thaliana N-Myc Downstream Regulated 1 (NDRG1) Interaktionspartner

  1. NDR1 plays a broad role both in mediating primary cellular functions in Arabidopsis through maintaining the integrity of the cell wall-plasma membrane connection and as a key signaling component of these responses during pathogen infection.

  2. SR1 plays an important role in plant immunity and ethylene signaling by directly regulating NDR1 and EIN3.

  3. The induction of defence responses and disease resistance to X. campestris pv. campestris strain 8004 requires NDR1 , RAR1 and SGT1b, suggesting that effector-triggered immunity plays a large role in resistance to this strain.

  4. Sequence analysis and mass spectrometry suggest that NDR1 (zeige STK38 Proteine) is localized to the PM via a C-terminal glycosylphosphatidyl-inositol (GPI (zeige GPI Proteine)) anchor.

  5. demonstrate that the RIN4-NDR1 interaction occurs on the cytoplasmically localized N-terminal portion of NDR1 and that this interaction is required for the activation of resistance signaling following infection by P. syringae

  6. Mutations in NDR1 (zeige STK38 Proteine) abolished the enhanced resistance of dnd (zeige DND1 Proteine) mutants against Pseudomonas syringae pv. tomato and Hyaloperonospora parasitica but not Botrytis cinerea.

N-Myc Downstream Regulated 1 (NDRG1) Protein Überblick

Protein Überblick

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Genbezeichner und Symbole assoziert mit NDRG1

  • N-myc downstream regulated 1 (NDRG1)
  • N-myc downstream regulated gene 1 (Ndrg1)
  • N-myc downstream regulated 1 (Ndrg1)
  • N-myc downstream regulated 1 (ndrg1-b)
  • N-myc downstream regulated 1 (ndrg1)
  • N-myc downstream regulated gene 1a (ndrg1a)
  • N-myc downstream regulated gene 1 (LOC100230327)
  • protein NDR1 (NDR1)
  • cap43 Protein
  • cb775 Protein
  • cmt4d Protein
  • DRG-1 Protein
  • drg1 Protein
  • gc4 Protein
  • hmsnl Protein
  • ndr1 Protein
  • NDRG1 Protein
  • ndrg4 Protein
  • Ndrl Protein
  • nmsl Protein
  • NON-RACE SPECIFIC DISEASE RESISTANCE PROTEIN Protein
  • non race-specific disease resistance 1 Protein
  • proxy1 Protein
  • rit42 Protein
  • rtp Protein
  • targ1 Protein
  • tdd5 Protein
  • wu:fb60h02 Protein
  • xndrg1 Protein
  • zgc:63944 Protein

Bezeichner auf Proteinebene für NDRG1

N-myc downstream-regulated gene 1 protein , differentiation-related gene 1 protein , nickel-specific induction protein Cap43 , protein NDRG1 , protein regulated by oxygen-1 , reducing agents and tunicamycin-responsive protein , N-myc downstream regulated 1 , protein Ndr1 , N-myc downstream regulated gene 1 , protein NDRG1-B , xNDRG1-B , protein NDRG1-like

GENE ID SPEZIES
10397 Homo sapiens
17988 Mus musculus
299923 Rattus norvegicus
380319 Xenopus laevis
420321 Gallus gallus
464411 Pan troglodytes
482049 Canis lupus familiaris
493508 Xenopus (Silurana) tropicalis
504499 Bos taurus
792085 Danio rerio
100068997 Equus caballus
100230327 Taeniopygia guttata
100401077 Callithrix jacchus
100466806 Ailuropoda melanoleuca
100596235 Nomascus leucogenys
697752 Macaca mulatta
821607 Arabidopsis thaliana
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