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NLRX1 encodes a member of the NLR family. Zusätzlich bieten wir Ihnen und NLRX1 Kits (1) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 58 products:
Human Polyclonal NLRX1 Primary Antibody für ELISA, WB - ABIN4340142
Tattoli, Carneiro, Jéhanno, Magalhaes, Shu, Philpott, Arnoult, Girardin: NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production. in EMBO reports 2008
NLRX1 exerted opposing regulatory effects on viral activation of the transcription factors IRF1 (zeige IRF1 Antikörper) and IRF3 (zeige IRF3 Antikörper). NLRX1 suppressed MAVS (zeige MAVS Antikörper)-mediated activation of IRF3 (zeige IRF3 Antikörper), it conversely facilitated virus-induced increases in IRF1 (zeige IRF1 Antikörper) expression and thereby enhanced control of viral infection.
downregulated in brain injury following aneurysm
The data suggests that NLRX1 plays a positive role in Kaposi's sarcoma-associated herpesvirus (KSHV) lytic replication by suppressing the IFNbeta response during the process of KSHV reactivation, which might serve as a potential target for restricting KSHV replication and transmission.
we identify a novel signaling hub centering on the NLRX1 TUFM (zeige Tufm Antikörper) protein complex, promoting autophagic flux. Defects in the expression of either NLRX1 or TUFM (zeige Tufm Antikörper) result in compromised autophagy when treated with EGFR (zeige EGFR Antikörper) inhibitors.These findings expand our understanding of the components involved in head and neck squamous cell carcinoma autophagy machinery that responds to EGFR (zeige EGFR Antikörper) inhibitors.
findings suggest that NLRX1 may function as a cardiac-protective molecule in myocardial ischemic injury by repressing inflammation and apoptosis
NLRX1, NLRP12 (zeige NLRP12 Antikörper) and NLRC3 (zeige NLRC3 Antikörper) negatively modulate the host immune response following virus exposure. (Review)
NLRX1 acts as a potential tumor suppressor by regulating the TNF-alpha (zeige TNF Antikörper) induced cell death and metabolism.
These data support a model in which CS-dependent NLRX1 inhibition facilitates MAVS (zeige MAVS Antikörper)/RHL (zeige DDX46 Antikörper) activation and subsequent inflammation, remodeling, protease, cell death, and inflammasome responses.
Together, these results suggest a novel mechanism for rhinovirus-induced epithelial barrier disruption involving NLRX-1 and mitochondrial reactive oxygen species generation.
NLRX1 and TUFM (zeige Tufm Antikörper) work in concert to reduce cytokine response and augment autophagy.
Nlrx1-/- mice exhibited significantly larger brain lesions and increased motor deficits following controlled cortical impact injury
this in vitro studies show that NLRX1-deficient T cells have a greater ability to differentiate into an inflammatory phenotype and possess greater proliferation rates
NLRX1 sequesters the DNA-sensing adaptor STING from interaction with TBK1 (zeige TBK1 Antikörper), which is a requisite for IFN-1 induction in response to viral DNA.
NLRX1 diminishes Tumor Necrosis Factor-alpha (zeige TNF Antikörper)-induced activation of both Akt (zeige AKT1 Antikörper)- and NF-kappaB (zeige NFKB1 Antikörper)-dependent pathways. Since Akt (zeige AKT1 Antikörper) was shown to be essential for Tumor Necrosis Factor-alpha (zeige TNF Antikörper)-mediated activation of NF-kappaB (zeige NFKB1 Antikörper) it is likely that the primary effect of NLRX1 is at the level of C-Akt (zeige AKT1 Antikörper) proein signaling.
NLRX1 attenuated Apc (zeige APC Antikörper)(min/+) colon tumorigenesis, cellular proliferation, NF-KappaB (zeige NFKB1 Antikörper), mitogen-activated protein kinase (zeige MAPK1 Antikörper), signal transducer and activator of transcription 3 (zeige STAT3 Antikörper) activation, and interleukin 6 (zeige IL6 Antikörper) levels.
NLRX1 may relate to hair cell maturity, hearing formation and maintenance, and promote hair cell apoptosis through JNK (zeige MAPK8 Antikörper) pathway
The regulatory role of NLRX1 in mechanisms of host tolerance employed by macrophages to respond to Helicobacter pylori infection.NLRX1 modulates innate immune responses to Helicobacter pylori infection.
Nlrx1 may play an important role in neurodegenerative diseases, where necrosis is a prominent factor.
The unique capacity of NLRX1 to regulate the cellular sensitivity toward intrinsic versus extrinsic apoptotic signals suggests a critical role for this protein in numerous physiological processes and pathological conditions.
This gene encodes a member of the NLR family. Alternative splicing has been observed at this gene locus and two transcript variants, encoding distinct isoforms, have been identified.
NLR family member X1
, NLR family, X1
, NOD-like receptor X1
, caterpiller protein 11.3
, nucleotide-binding oligomerization domain protein 26
, nucleotide-binding oligomerization domain protein 5
, nucleotide-binding oligomerization domain protein 9
, nucleotide-binding oligomerization domain, leucine rich repeat containing X1
, nucleotide-binding domain and leucine-rich repeat containing