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The protein encoded by NEK6 is a kinase required for progression through the metaphase portion of mitosis. Zusätzlich bieten wir Ihnen NEK6 Proteine (16) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal NEK6 Primary Antibody für WB - ABIN1882104
Belham, Roig, Caldwell, Aoyama, Kemp, Comb, Avruch: A mitotic cascade of NIMA family kinases. Nercc1/Nek9 activates the Nek6 and Nek7 kinases. in The Journal of biological chemistry 2003
Show all 4 Pubmed References
NEK6 is overexpressed in various human cancer tissues, and ectopic expression of NEK6 increases tumor promoter-induced transformation of JB6 Cl41 mouse epidermal cells.
During early embryogenesis nek6 is highly expressed in primary giant trophoblast cells. Later in embryogenesis, nek6 is found in ventricular and sub-ventricular regions.
NEK6 (zeige NEK5 Antikörper) forms heterodimers with NEK4 and NEK5 to regulate cortical microtubule organization possibly through the phosphorylation of beta-tubulins.
cis (zeige CISH Antikörper)-regulatory circuits that lead to overexpression of NEK6, a mitosis-associated kinase, in human B cell lymphoma, were analyzed.
High NEK6 expression is associated with Cluster Amplified Centrosomes in cancer.
Signaling cascade of the NIMA-related kinases (Neks) Nek6, Nek7 (zeige NEK7 Antikörper), and Nek9 (zeige NEK9 Antikörper) is required for the localization and function of two kinesins essential for cytokinesis, Mklp2 (zeige KIF20A Antikörper) and Kif14 (zeige KIF14 Antikörper) to properly coordinate cytokinesis.
our studies establish NEK6 signaling as a central mechanism mediating castration-resistant prostate cancer
overexpression of PAK1 (zeige PAK1 Antikörper), NEK6, AURKA (zeige AURKA Antikörper), and AURKB (zeige AURKB Antikörper) genes in patients with Colorectal adenomatous polyp and colorectal cancer in the Turkish population.
We found that NEK6-mediated phosphorylation of TPP1 (zeige TPP1 Antikörper) Ser255 in G2/M phase regulates the association between telomerase activity and TPP1 (zeige TPP1 Antikörper). Furthermore, we found evidence that POT1 (zeige POT1 Antikörper) negatively regulates TPP1 (zeige TPP1 Antikörper) phosphorylation because the level of Ser255 phosphorylation was elevated when telomeres were elongated by a POT1 (zeige POT1 Antikörper) mutant lacking its OB-fold domains
Overexpression of AURKA (zeige AURKA Antikörper) and NEK6 genes was significantly more pronounced in Ulcerative colitis patients with more extensive colon involvement
NEK6 suppresses the cell growth arrest induced by TGFbeta (zeige TGFB1 Antikörper). Mechanically, NEK6 blocks nuclear translocation of Smad4 (zeige SMAD4 Antikörper), which is essential for TGFbeta (zeige TGFB1 Antikörper) function.
Nek6 is also a critical signaling molecule that helps prevent cardiac hypertrophy and inhibits the Akt (zeige AKT1 Antikörper) signaling pathway.
Nek6 facilitates association of Hsp72 (zeige HSPA1A Antikörper) with the mitotic spindle, where it promotes stable K-fiber assembly through recruitment of the ch-TOG (zeige CKAP5 Antikörper)-TACC3 (zeige TACC3 Antikörper) complex.
The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene.
NIMA-related expressed kinase 6
, never in mitosis A-related kinase 6
, nimA-related protein kinase 6
, serine/threonine-protein kinase Nek6
, putative serine-threonine protein kinase
, NIMA (never in mitosis gene a)-related kinase 6
, protein kinase SID6-1512
, NIMA (never in mitosis gene a)-related expressed kinase 6