NIMA (Never in Mitosis Gene A)- Related Kinase 9 Proteine (NEK9)

Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Zusätzlich bieten wir Ihnen NIMA (Never in Mitosis Gene A)- Related Kinase 9 Antikörper (132) und NIMA (Never in Mitosis Gene A)- Related Kinase 9 Kits (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
NEK9 217718 Q8K1R7
NEK9 91754 Q8TD19
Ratte NEK9 NEK9 299204  
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Showing 7 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
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Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 66 Days
10.536,00 €
Details
HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen 6 bis 8 Tage
748,00 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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Insektenzellen Human GST tag   5 μg Anmelden zum Anzeigen 7 bis 8 Tage
640,00 €
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Insektenzellen Human GST tag   10 μg Anmelden zum Anzeigen 7 bis 9 Tage
304,76 €
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HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Anmelden zum Anzeigen 6 bis 8 Tage
306,74 €
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NEK9 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , , ,
, ,

Weitere Proteine zu NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) Interaktionspartnern

Zebrafish NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) Interaktionspartner

  1. requirement for Nek8 (zeige NEK8 Proteine) in left-right patterning is conserved

  2. Nek8 (zeige NEK8 Proteine) acts downstream of Inv (zeige INVS Proteine) function

  3. cross-species analysis between zebrafish and mouse demonstrates taht NEK8 (zeige NEK8 Proteine) has a role in development of pronephric cysts

Xenopus laevis NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) Interaktionspartner

  1. Nercc1 contributes to both the centrosomal and the chromatin/Ran pathways that collaborate in the organization of a bipolar spindle

Mouse (Murine) NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) Interaktionspartner

  1. NEK9 is a critical component of the replication stress response that promotes CHK1 (zeige CHEK1 Proteine) activity, maintaining genome integrity following challenges to DNA replication.

  2. Knockdown of Nek9 also impaired the spindle-pole localization of gamma-tubulin (zeige TUBG1 Proteine) and resulted in retention of the spindle assembly checkpoint protein Bub3 (zeige BUB3 Proteine) at the kinetochores.

Human NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) Interaktionspartner

  1. Recessive NEK9 mutation is associated with lethal skeletal dysplasia.

  2. Somatic Mutations in NEK9 Cause Nevus Comedonicus.

  3. Overall, these results highlight the complexity of virus-host interactions and identify a new role for the cellular protein Nek9 during human adenovirus infection, suggesting a role for Nek9 in regulating p53 (zeige TP53 Proteine) target gene expression.

  4. The C-terminal domain of Nek9 activates Nek7 (zeige NEK7 Proteine) through promoting back-to-back dimerization.

  5. The findings demonstrate that a novel NEK9 network regulates the growth of cancer cells lacking functional p53 (zeige TP53 Proteine).

  6. NEK9 inhibition represents a novel anti-cancer strategy by induction of mitotic catastrophe via impairment of spindle dynamics, cytokinesis and mitotic checkpoint (zeige BUB3 Proteine) control.

  7. Structural analysis of LC8 (zeige DYNLL1 Proteine) with both Nek9 peptides, together with different biophysical experiments, explains the observed diminished binding affinity of Nek9 to LC8 (zeige DYNLL1 Proteine) upon phosphorylation on Ser (zeige SIGLEC1 Proteine)(944) within the Nek9 sequence

  8. Nek9 phosphorylates NEDD1 (zeige NEDD1 Proteine) on Ser377 driving its recruitment and thereby that of gamma-tubulin (zeige TUBG1 Proteine) to the centrosome in mitotic cells.

  9. The interaction between the human NimA-like protein kinase (zeige CDK7 Proteine) Nek9 and the Helicobacter HcpC has been validated by ELISA and surface plasmon resonance.

  10. Nek9 is a Plk1-activated kinase that controls early centrosome separation through Nek6 (zeige NEK6 Proteine)/7 and Eg5 (zeige KIF11 Proteine).

NIMA (Never in Mitosis Gene A)- Related Kinase 9 (NEK9) Protein Überblick

Protein Überblick

Pleiotropic regulator of mitotic progression, participating in the control of spindle dynamics and chromosome separation. Phosphorylates different histones, myelin basic protein, beta-casein, and BICD2. Phosphorylates histone H3 on serine and threonine residues and beta-casein on serine residues Important for G1/S transition and S phase progression. Phosphorylates NEK6 and NEK7 and stimulates their activity by releasing the autoinhibitory functions of Tyr-108 and Tyr-97 respectively (By similarity).

Genbezeichner und Symbole assoziert mit NEK9

  • NIMA (never in mitosis gene a)- related kinase 9 (NEK9)
  • NIMA (never in mitosis gene a)-related kinase 8 (nek8)
  • NIMA (never in mitosis gene a)- related kinase 8 (nek8)
  • NIMA (never in mitosis gene a)- related kinase 8 (NEK8)
  • NIMA-related kinase 9 (nek9)
  • NIMA-related kinase 8 (LOC100345106)
  • NIMA (never in mitosis gene a)- related kinase 9 (nek9)
  • NIMA (never in mitosis gene a)-related expressed kinase 9 (Nek9)
  • NIMA-related kinase 9 (NEK9)
  • NIMA-related kinase 9 (Nek9)
  • C130021H08Rik Protein
  • jck Protein
  • MGC80499 Protein
  • MGC88903 Protein
  • Nek8 Protein
  • NEK9 Protein
  • nek12a Protein
  • NERCC Protein
  • NERCC1 Protein
  • nphp9 Protein

Bezeichner auf Proteinebene für NEK9

serine/threonine-protein kinase Nek9 , NIMA-related kinase 8 , never in mitosis A-related kinase 8 , nimA-related protein kinase 8 , serine/threonine-protein kinase Nek8 , NIMA (never in mitosis gene a)- related kinase 8 , NIMA (never in mitosis gene a)- related kinase 9 , NIMA (never in mitosis gene a)-related expressed kinase 8 , serine/threonine-protein kinase Nek9-like , nercc1 kinase , never in mitosis A-related kinase 9 , nimA-related protein kinase 9 , NIMA-related kinase Nek8 , nimA-related kinase 8 , NIMA-family kinase Nercc1 , XNek9

GENE ID SPEZIES
428891 Gallus gallus
534652 Bos taurus
100152772 Sus scrofa
171094 Danio rerio
448753 Xenopus (Silurana) tropicalis
455033 Pan troglodytes
701707 Macaca mulatta
779142 Xenopus laevis
100216232 Xenopus (Silurana) tropicalis
100345106 Oryctolagus cuniculus
100461917 Pongo abelii
100474361 Ailuropoda melanoleuca
100543466 Meleagris gallopavo
100556817 Anolis carolinensis
490790 Canis lupus familiaris
217718 Mus musculus
91754 Homo sapiens
299204 Rattus norvegicus
398600 Xenopus laevis
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