Myosin Regulatory Light Chain Interacting Protein Proteine (MYLIP)

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Zusätzlich bieten wir Ihnen MYLIP Antikörper (58) und MYLIP Kits (1) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MYLIP 29116 Q8WY64
MYLIP 218203 Q8BM54
MYLIP 306825 D3ZDI6
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Showing 6 out of 12 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 56 Days
7.380,00 €
Details
HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
345,60 €
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HOST_Escherichia coli (E. coli) Human GST tag   50 μg Anmelden zum Anzeigen 15 bis 16 Tage
324,76 €
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Hefe Human His tag   50 μg Anmelden zum Anzeigen 12 bis 16 Tage
324,76 €
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Hefe Ratte His tag   1 mg Anmelden zum Anzeigen 58 bis 70 Tage
3.092,22 €
Details

MYLIP Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
,
Mouse (Murine)

Rat (Rattus)

Weitere Proteine zu Myosin Regulatory Light Chain Interacting Protein (MYLIP) Interaktionspartnern

Zebrafish Myosin Regulatory Light Chain Interacting Protein (MYLIP) Interaktionspartner

Human Myosin Regulatory Light Chain Interacting Protein (MYLIP) Interaktionspartner

  1. the effects caused by human inducible degrader of the low-density lipoprotein expression are LDLR (zeige LDLR Proteine)- dependent given the unchanged plasma lipids in LAhB mice lacking low-density lipoprotein receptor (zeige LDLR Proteine)

  2. The long noncoding RNA RP1-13D10.2 may contribute to LDL cholesterol levels in response to statins.

  3. Specifically, loss of IDOL increases LDLR (zeige LDLR Proteine) distribution in the hepatic cell, and subsequently reduces serum LDL-C levels in dyslipidemic patients

  4. Data suggest inducible expression of IDOL is subject to robust, rapid regulation by process that is sensitive to deubiquitinase inhibition in human/mouse cell lines and primary human cells; transcriptional induction of IDOL leads to degradation of LDLR (zeige LDLR Proteine).

  5. Identify USP2 (zeige USP2 Proteine) as a novel regulator of lipoprotein clearance owing to its ability to control ubiquitylation-dependent degradation of the LDLR (zeige LDLR Proteine) by IDOL.

  6. The study identified MARCH6 (zeige MARCH6 Proteine) as a negative regulator of SREBP2 (zeige SREBF2 Proteine)-mediated transcription and described an unexpected E3 circuit functionally linking MARCH6 (zeige MARCH6 Proteine) and IDOL to limit uptake of low-density lipoprotein via the LDLR (zeige LDLR Proteine) pathway.

  7. IDOL N342S Variant, Atherosclerosis Progression and Cardiovascular Disorders in the Italian General Population.

  8. study indicates that MYLIP p.N342S might be a pharmacogenetic marker for lipid-lowering therapy in patients with FH.

  9. Liver-specific expression of dominant-active IDOL is associated with hypercholesterolemia and a marked elevation in atherosclerotic lesions in transgenic mice.

  10. evidence for the existence of an LXR (zeige NR1H3 Proteine)-IDOL-mediated internalization pathway for the LDLR (zeige LDLR Proteine) that is distinct from that used for lipoprotein uptake

Mouse (Murine) Myosin Regulatory Light Chain Interacting Protein (MYLIP) Interaktionspartner

  1. the effects caused by human inducible degrader of the low-density lipoprotein expression are LDLR (zeige LDLR Proteine)- dependent given the unchanged plasma lipids in LAhB mice lacking low-density lipoprotein receptor (zeige LDLR Proteine)

  2. Suggest Idol as a gatekeeper of LDLR (zeige LDLR Proteine)-dependent ApoE (zeige APOE Proteine) and Abeta (zeige APP Proteine) clearance in the brain and a potential enzyme target for therapeutic intervention in Alzheimer disease.

  3. Estradiol-treatment led to impaired contractile function in male cardiomyocytes only, which was characterized by increased Mylip mRNA and protein levels, and decreased myosin regulatory light chain protein.

  4. These data identify the IDOL-LDLR (zeige LDLR Proteine) interaction as an evolutionarily conserved mechanism for the regulation of lipid uptake and suggest that this interaction could potentially be exploited for the pharmacologic modulation of lipid metabolism.

  5. Data show that NPC1 (zeige NPC1 Proteine) deficiency has a major impact on VLDL metabolism in Apoe (zeige APOE Proteine)(-/-) mice through modulation of hepatic LDL-R protein levels, and a modest one on Pcsk9 (zeige PCSK9 Proteine) and Idol induction.

  6. Data show that the identification of VLDLR (zeige VLDLR Proteine) and ApoER2 (zeige LRP8 Proteine) as Idol(Mylip) targets suggests potential roles for this LXR (zeige NR1H3 Proteine)-inducible E3 ligase in the central nervous system in addition to lipid metabolism.

  7. study shows the LXR (zeige NR1H3 Proteine)-Idol(Mylip)-LDLR (zeige LDLR Proteine) axis defines a complementary pathway to sterol response element-binding proteins for sterol regulation of cholesterol uptake

MYLIP Protein Überblick

Protein Überblick

The ERM protein family members ezrin, radixin, and moesin are cytoskeletal effector proteins linking actin to membrane-bound proteins at the cell surface. Myosin regulatory light chain interacting protein (MYLIP) is a novel ERM-like protein that interacts with myosin regulatory light chain and inhibits neurite outgrowth.

Genbezeichner und Symbole assoziert mit MYLIP

  • myosin regulatory light chain interacting protein a (mylipa)
  • myosin regulatory light chain interacting protein (MYLIP)
  • myosin regulatory light chain interacting protein (mylip)
  • myosin regulatory light chain interacting protein (Mylip)
  • 9430057C20Rik Protein
  • IDOL Protein
  • MIR Protein
  • MYLIP Protein
  • wu:fj36b03 Protein
  • zgc:55987 Protein

Bezeichner auf Proteinebene für MYLIP

E3 ubiquitin-protein ligase MYLIP-A , MIR-A , myosin regulatory light chain-interacting protein A , myosin regulatory light chain interacting protein , e3 ubiquitin-protein ligase MYLIP-like , E3 ubiquitin ligase-inducible degrader of the low density lipoprotein receptor , E3 ubiquitin-protein ligase MYLIP , band 4.1 superfamily member BZF1 , cellular modulator of immune recognition (c-MIR) , inducible degrader of the LDL-receptor , myosin regulatory light chain-interacting protein , idol

GENE ID SPEZIES
335888 Danio rerio
462452 Pan troglodytes
549813 Xenopus (Silurana) tropicalis
702625 Macaca mulatta
100018640 Monodelphis domestica
100065647 Equus caballus
100155795 Sus scrofa
100436766 Pongo abelii
100563531 Anolis carolinensis
100586926 Nomascus leucogenys
29116 Homo sapiens
218203 Mus musculus
306825 Rattus norvegicus
494986 Xenopus laevis
420841 Gallus gallus
488230 Canis lupus familiaris
541070 Bos taurus
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