anti-Multiple Coagulation Factor Deficiency 2 (MCFD2) Antikörper

MCFD2 encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. Zusätzlich bieten wir Ihnen Multiple Coagulation Factor Deficiency 2 Kits (11) und Multiple Coagulation Factor Deficiency 2 Proteine (11) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MCFD2 90411 Q8NI22
Anti-Maus MCFD2 MCFD2 193813 Q8K5B2
MCFD2 246117 Q8K5B3
Direkt bei antikoerper-online bestellen
  • +49 (0)241 95 163 153
  • +49 (0)241 95 163 155
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-Multiple Coagulation Factor Deficiency 2 Antikörper auf antikoerper-online.de

Showing 10 out of 41 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert WB MCFD2 Antibody  western blot analysis in U251 cell line lysates (35ug/lane).This demonstrates the MCFD2 antibody detected the MCFD2 protein (arrow). 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of MCFD2 expression in HEK293T (A), A549 (B), PC12 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 11 bis 13 Tage
464,29 €
Details
Human Maus Unkonjugiert IHC (p), ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
635,55 €
Details
Human Kaninchen APC IHC, ELISA   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.203,02 €
Details
Human Kaninchen FITC IHC, ELISA   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.203,02 €
Details
Human Kaninchen PE IHC, ELISA   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.203,02 €
Details
Human Kaninchen Biotin IHC, ELISA   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.203,02 €
Details
Human Kaninchen Alkaline Phosphatase (AP) IHC, ELISA   200 μL Anmelden zum Anzeigen 11 bis 14 Tage
1.203,02 €
Details
Human Maus Unkonjugiert IF, ELISA, WB Western Blot detection against Immunogen (41.8 KDa) . Immunofluorescence of monoclonal antibody to MCFD2 on HeLa cell. [antibody concentration 10 ug/ml] 100 μg Anmelden zum Anzeigen 7 bis 8 Tage
369,60 €
Details
Human Maus Unkonjugiert IHC (p), RNAi, ELISA, WB Immunoperoxidase of monoclonal antibody to MCFD2 on formalin-fixed paraffin-embedded human ovary, clear cell carcinoma. [antibody concentration 3 ug/ml] Western blot analysis of MCFD2 over-expressed 293 cell line, cotransfected with MCFD2 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with MCFD2 monoclonal antibody (M01), clone 3A5-G4. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg Anmelden zum Anzeigen 7 bis 8 Tage
369,60 €
Details

MCFD2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , , ,
, ,
,
, , , , ,
Rat (Rattus)


Weitere Antikörper gegen Multiple Coagulation Factor Deficiency 2 Interaktionspartner

Xenopus laevis Multiple Coagulation Factor Deficiency 2 (MCFD2) Interaktionspartner

  1. Results indicate the biological roles of MCFD2 in both vertebrates and invertebrates.

Human Multiple Coagulation Factor Deficiency 2 (MCFD2) Interaktionspartner

  1. A novel missense mutation, namely Asp81Ala in exon 3 of MCFD2 gene, is firstly reported and described as a cause of combined FV and FVIII (zeige F8 Antikörper) deficiency in a Chinese family.

  2. Studies indicate that the LMAN1 (zeige LMAN1 Antikörper)-CRD (zeige CRX Antikörper) contains distinct, separable binding sites for both its partner protein MCFD2 and the cargo proteins FV/FVIII (zeige F8 Antikörper).

  3. Results indicate the biological roles of MCFD2 in both vertebrates and invertebrates.

  4. Data indicate that together with its soluble coreceptor MCFD2, LMAN1 (zeige LMAN1 Antikörper) transports coagulation factors V (FV) and VIII (zeige COX8A Antikörper) (FVIII (zeige F8 Antikörper)).

  5. Mutations in MCFD2 lead to F5F8D (zeige LMAN1 Antikörper) (combined deficiency of factor V And factor VIII) due to alterations in MCFD2-LMAN1 (zeige LMAN1 Antikörper) complex of coat protein (zeige GOLPH3 Antikörper) (COP (zeige CARD16 Antikörper))II complex trafficking machinery; 30% of F5F8D (zeige LMAN1 Antikörper) patients have mutations in MCFD2. [REVIEW]

  6. We present the identification of a novel MCFD2 gene missense mutation by direct sequencing.

  7. The study reports for the first time a case of Combined factor V and factor VIII deficiency disorder in a Tunisian family, resulting from two novel mutations in exon 3 of the MCFD2 gene.

  8. Data present the crystal structure of the LMAN1 (zeige LMAN1 Antikörper)/MCFD2 complex and relate it to patient mutations. Circular dichroism data show that the majority of the substitution mutations give rise to a disordered or severely destabilized MCFD2 protein.

  9. Data show that mutations in MCFD2 that disrupt the tertiary structure and abolish LMAN1 (zeige LMAN1 Antikörper) binding still retain the FV/FVIII (zeige F8 Antikörper) binding activities, suggesting that this interaction is independent of Ca(2 (zeige CA2 Antikörper)+)-induced folding of the protein.

  10. inactivating mutations in MCFD2 cause combined deficiency of factor V and factor VIII with a phenotype indistinguishable from that caused by mutations in LMAN1 (zeige LMAN1 Antikörper)

Mouse (Murine) Multiple Coagulation Factor Deficiency 2 (MCFD2) Interaktionspartner

Multiple Coagulation Factor Deficiency 2 (MCFD2) Antigen-Profil

Protein Überblick

This gene encodes a soluble luminal protein with two calmodulin-like EF-hand motifs at its C-terminus. This protein forms a complex with LAMN1 (lectin mannose binding protein 1\; also known as ERGIC-53) that facilitates the transport of coagulation factors V (FV) and VIII (FVIII) from the endoplasmic reticulum to the Golgi apparatus via an endoplasmic reticulum Golgi intermediate compartment (ERGIC). Mutations in this gene cause combined deficiency of FV and FVIII (F5F8D)\; a rare autosomal recessive bleeding disorder characterized by mild to moderate bleeding and coordinate reduction in plasma FV and FVIII levels. This protein has also been shown to maintain stem cell potential in adult central nervous system and is a marker for testicular germ cell tumors. The 3' UTR of this gene contains a transposon-like human repeat element named 'THE 1'. A processed RNA pseudogene of this gene is on chromosome 6p22.1. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Genbezeichner und Symbole assoziert mit MCFD2

  • multiple coagulation factor deficiency 2 (MCFD2) Antikörper
  • multiple coagulation factor deficiency 2 (mcfd2) Antikörper
  • multiple coagulation factor deficiency 2 (LOC100353154) Antikörper
  • multiple coagulation factor deficiency 2 (Mcfd2) Antikörper
  • 1810021C21Rik Antikörper
  • DKFZp469B098 Antikörper
  • F5f8d Antikörper
  • F5F8D2 Antikörper
  • hm:zeh1186 Antikörper
  • Lman1ip Antikörper
  • MCFD2 Antikörper
  • Sdnsf Antikörper
  • wu:fc23b10 Antikörper
  • wu:fd50d08 Antikörper
  • zgc:103713 Antikörper
  • zgc:109915 Antikörper

Bezeichner auf Proteinebene für MCFD2

multiple coagulation factor deficiency 2 , multiple coagulation factor deficiency protein 2 , Multiple coagulation factor deficiency protein 2 homolog , neural stem cell derived neuronal survival protein , neural stem cell-derived neuronal survival protein , multiple coagulation factor deficiency protein 2 homolog , stem cell derived neuronal survival protein

GENE ID SPEZIES
421413 Gallus gallus
449676 Danio rerio
459210 Pan troglodytes
474582 Canis lupus familiaris
496472 Xenopus (Silurana) tropicalis
616647 Bos taurus
100137636 Xenopus laevis
100174341 Pongo abelii
100353154 Oryctolagus cuniculus
90411 Homo sapiens
193813 Mus musculus
246117 Rattus norvegicus
Ausgewählte Anbieter für anti-Multiple Coagulation Factor Deficiency 2 (MCFD2) Antikörper
Haben Sie etwas anderes gesucht?