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Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an.
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High TRPML-2 expression in glioma cells resulted in increased survival and proliferation signaling, suggesting a pro-tumorigenic role played by TRPML-2 in glioma progression.
MCOLN2 is transcriptionally activated by PAX5 (zeige PAX5 Antikörper) and has roles in B cell development and function
TRPML2 is activated by lowering the extracellular sodium concentration as well as by a subset of small chemical compounds that were previously identified as activators of TRPML3 (zeige Mcoln3 Antikörper).
TRPML 1 (zeige MCOLN1 Antikörper), 2 and 3 assemblies regulated cell viability and starvation-induced autophagy.
constitutively active h-TRPML2 leads to cell death by causing Ca(2 (zeige CA2 Antikörper)+) overload
there is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 (zeige MCOLN1 Antikörper) and TRPML2 dictate the localization of TRPML3 (zeige Mcoln3 Antikörper) and not vice versa
MCOLN2 traffics through the ADP-ribosylation factor 6 (Arf6 (zeige ARF6 Antikörper))-associated pathway, colocalizing with major histocompatibility protein class I and CD59 (zeige CD59 Antikörper) in long recycling endosomes.
TRPML1 (zeige MCOLN1 Antikörper) appears to play a novel role in the tissue-specific transcriptional regulation of TRPML2.
study reveals interesting differences in the regulation and distribution of the members of the TRPML family and identifies a novel role for TRPML2 in the innate immune response.
Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007
, mucolipin 2
, mucolipidin 2