Mitochondrially Encoded NADH Dehydrogenase 4 Proteine (MT-ND4)

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Zusätzlich bieten wir Ihnen Mitochondrially Encoded NADH Dehydrogenase 4 Antikörper (4) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
MT-ND4 4538 P03905
MT-ND4 17719 P03911
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Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 46 bis 51 Tage
4.032,65 €
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Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 46 bis 51 Tage
5.743,80 €
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HOST_Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 7 bis 8 Tage
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MT-ND4 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human ,
,
Mouse (Murine)

Weitere Proteine zu Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) Interaktionspartnern

Human Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) Interaktionspartner

  1. MT-ND4 and MT-TL1 (zeige TNFSF15 Proteine) genetic variation might be associated with male infertility in Chinese patients.

  2. this paper identified m.11240C4T in ND4 as a novel mitochondrial disease-related mtDNA mutation in Leigh syndrome.

  3. We identified a genetic association between the MT-ND4 11719 A/G polymorphism and Ulcerative Colitis in the subgroup of males. The male-specific association indicates differences between males and females concerning the impact of mitochondrial gene polymorphisms on the development of Ulcerative Colitis.

  4. The molecular study of a family with one member with Leber hereditary optic neuropathy found the mitochondrial mutation m.11778G>A in MT-ND4.

  5. the ND4 gene is the hot spot for mutations associated with Leber's hereditary optic neuropathy

  6. Three mutations were significantly related to the presence of epilepsy. These mutations were found at the 8502, 11994, and 13,231 bp of mtDNA, which resulted in amino acid changes at the MT-ATP-8 (zeige MT-ATP8 Proteine), MT-ND4 and MT-ND5 (zeige MT-ND5 Proteine) genes.

  7. Expression of WT human ND4 in cells with the G11778A mutation in ND4 led to restoration of defective ATP synthesis.

  8. altered activity of complex III modulates the phenotypic manifestation of Leber's hereditary optic neuropathy-associated ND4 G11778A mutation

  9. Patients with somatically acquired ND4 mutations had significantly longer relapse-free survival (P=0.017) and overall survival (OS) (P=0.021) than ND4(wildtype) patients

  10. Molecular analysis of mitochondrial genome identified the known ND4 G11778A mutation and 51 variants, belonging to Asian haplogroup C4a1.

Mouse (Murine) Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) Interaktionspartner

  1. Cybrid mice showed normal respiratory function whether or not their mtDNA possessed the A11181G mutation of the mt-Nd4 gene, suggesting that the this mutation is not responsible for respiration defects found in SAMP8 mice.

Arabidopsis thaliana Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) Interaktionspartner

  1. Data indicate that SLOW GROWTH 4 (SLO4) is a mitochondrial pentatricopeptide repeat (PPR) protein that is involved in editing NADH dehydrogenase subunit 4 (nad4), possibly required for the efficient splicing of NADH dehydrogenase subunit 2 (nad2) intron1.

  2. The data supports a model for MTSF1 functioning in which its association with the last nucleotides of the nad4 3' untranslated region stabilizes nad4 mRNA.

Mitochondrially Encoded NADH Dehydrogenase 4 (MT-ND4) Protein Überblick

Protein Überblick

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).

Genbezeichner und Symbole assoziert mit MT-ND4

  • mitochondrially encoded NADH dehydrogenase 4 (MT-ND4)
  • NADH dehydrogenase 4, mitochondrial (mt-Nd4)
  • NADH dehydrogenase subunit 4 (ND4)
  • NADH dehydrogenase subunit 4 (nad4)
  • NADH dehydrogenase subunit 4 (NAD4)
  • NADH dehydrogenase, subunit 4 (nad4)
  • MTND4 Protein
  • NADH4 Protein

Bezeichner auf Proteinebene für MT-ND4

NADH dehydrogenase subunit 4

GENE ID SPEZIES
4538 Homo sapiens
17719 Mus musculus
3283886 Bos taurus
804483 Canis lupus familiaris
807643 Gallus gallus
808510 Sus scrofa
808225 Oryctolagus cuniculus
2565705 Caenorhabditis elegans
814596 Arabidopsis thaliana
807666 Ascaris suum
807960 Locusta migratoria
802562 Candida albicans SC5314
808213 Branchiostoma lanceolatum
1734028 Acanthamoeba castellanii
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