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MAP6 encodes a microtubule-associated protein. Zusätzlich bieten wir Ihnen MAP6 Antikörper (12) und viele weitere Produktgruppen zu diesem Protein an.
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These data show that TMEM106B/MAP6 interaction is crucial for controlling dendritic trafficking of lysosomes, presumably by acting as a molecular brake for retrograde transport.
Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin.
MAP6 might serve as a temperature sensor adapting its conformation according to the temperature to maintain the cellular microtubule network in organisms exposed to temperature decrease.
MAP6 is present at the Golgi complex and in secretory vesicles in unpolarized cells and re-distributed to newly forming axons, where it binds and stabilizes axonal microtubules. A palmitoylation cycle controls MAP6 membrane-microtubule shuttling and is required for its polarized distribution in axons.
Mice deficient in stable tubule only polypeptide (STOP) show sleep/wake patterns that resemble those seen in patients with schizophrenia.
MAP6 deletion disrupts brain connectivity and is associated with a lack of post-commissural fornix fibres. MAP6 contributes to fornix development by regulating axonal elongation induced by Semaphorin 3E (zeige SEMA3E Proteine).
STOP/Map6 knockout mice are a valid model for cognitive deficits in schizophrenia.
STOP null mice displayed elevated levels of endogenous morphine, as well as an increase of morphine receptor affinity and density in brain. This was correlated with hypernociception and impaired pharmacological sensitivity to mu opioid receptor (zeige OPRM1 Proteine) ligands
interacts with neuronal tubulin (zeige TUBB Proteine) independently of polyglutamylation
there is a single neuronal specific promoter for transcription of E- and N-STOP mRNAs. F-STOP mRNA transcription is regulated by a distinct promoter that lies within coding sequences expressed in neuronal E- and N-STOP isoforms.
STOP phosphorylation by CaMKII may promote STOP translocation from microtubules to synaptic compartments where it may interact with actin, which could be important for STOP function in synaptic plasticity
These results demonstrate that both STOP and MBP (zeige MBP Proteine) function as microtubule-stabilizing proteins in differentiating oligodendrocytes and could be important for the morphogenetic function of MBP (zeige MBP Proteine).
This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene.
, stable tubule-only polypeptide
, 145-kDa STOP
, microtubule-associated protein 6 homolog
, MAP-6 homolog
, putative microtubule associated protein
, stable tubule-only polypeptide homolog