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Metalloproteinase Inhibitor 1 Proteine (TIMP1)

TIMP1 belongs to the TIMP gene family. Zusätzlich bieten wir Ihnen TIMP1 Antikörper (258) und TIMP1 Kits (138) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
TIMP1 7076 P01033
TIMP1 116510 P30120
TIMP1 21857 P12032
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Top TIMP1 Proteine auf antikoerper-online.de

Showing 10 out of 60 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
HOST_Human Cells Human His tag 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
237,50 €
Details
HOST_HEK-293 Maus Unkonjugiert 10 μg Anmelden zum Anzeigen 6 bis 8 Tage
196,71 €
Details
HOST_Human Cells Maus Unkonjugiert 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
312,50 €
Details
HOST_Human Cells Ratte Unkonjugiert 10 μg Anmelden zum Anzeigen 18 bis 20 Tage
312,50 €
Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
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HOST_HEK-293 Cells Human His tag 10 μg Anmelden zum Anzeigen 6 bis 8 Tage
325,92 €
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 46 Days
5.173,33 €
Details
HOST_HEK-293 Human Unkonjugiert   10 μg Anmelden zum Anzeigen 6 bis 8 Tage
196,71 €
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HOST_Human Human Unkonjugiert 10 μg Anmelden zum Anzeigen 2 bis 3 Tage
381,33 €
Details
HOST_Escherichia coli (E. coli) Human MBP tag 10% SDS-PAGE stained with Coomassie Blue (CB) and peptide fingerprinting by MALDI-TOF mass spectrometry 50 μg Anmelden zum Anzeigen 2 bis 5 Tage
504,17 €
Details

TIMP1 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , , , , , , , , ,
, , ,
Rat (Rattus) ,

Mouse (Murine) , , , ,
,

Am meisten referenzierte TIMP1 Proteine

  1. Human TIMP1 Protein expressed in HEK-293 - ABIN2666716 : Kim, Kim, Kang, Ko: Expression level and glycan dynamics determine the net effects of TIMP-1 on cancer progression. in BMB reports 2012 (PubMed)
    Zeige alle 4 Referenzen für ABIN2666716

  2. Human TIMP1 Protein expressed in Human Cells - ABIN2003615 : Osthues, Knäuper, Oberhoff, Reinke, Tschesche: Isolation and characterization of tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid synovial fluid. in FEBS letters 1992 (PubMed)
    Zeige alle 4 Referenzen für ABIN2003615

  3. Rat (Rattus) TIMP1 Protein expressed in Human Cells - ABIN2009111 : Aljada, Ramnath, Donohue, Harvey, Brooks, Wiseman, Khoury, Loewen, Slocum, Anderson, Bepler, Tan: Upregulation of the tissue inhibitor of metalloproteinase-1 protein is associated with progression of human non-small-cell lung cancer. in Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2004 (PubMed)
    Zeige alle 4 Referenzen für ABIN2009111

  4. Mouse (Murine) TIMP1 Protein expressed in HEK-293 - ABIN2666718 : Brew, Nagase: The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. in Biochimica et biophysica acta 2010 (PubMed)
    Zeige alle 4 Referenzen für ABIN2666718

  5. Mouse (Murine) TIMP1 Protein expressed in Human Cells - ABIN2007691 : Hornebeck: Down-regulation of tissue inhibitor of matrix metalloprotease-1 (TIMP-1) in aged human skin contributes to matrix degradation and impaired cell growth and survival. in Pathologie-biologie 2003 (PubMed)
    Zeige alle 4 Referenzen für ABIN2007691

Weitere Proteine zu Metalloproteinase Inhibitor 1 (TIMP1) Interaktionspartnern

Cow (Bovine) Metalloproteinase Inhibitor 1 (TIMP1) Interaktionspartner

  1. Decreased MMP-9 (zeige MMP9 Proteine) and increased TIMP-1 expression were found in peripheral blood cells from Mycobacterium avium subsp. paratuberculosis (Map)-infected cattle after stimulation with Map lysate and Map purified protein derivative than in control cattle.

  2. We used a trophoblast cell line (F3) derived from bovine placentomes to examine the influence of EGF (zeige EGF Proteine) on MMP-9 (zeige MMP9 Proteine) and TIMP-1 expression by semiquantitative RT-PCR and MMP activity by zymography.

  3. Production of TIMP-1 was augmented by IL-1alpha, TNFalpha (zeige TNF Proteine), and hepatocyte growth factor (zeige HGF Proteine) at level of translation and was transcriptionally increased by 12-O-tetradecanoylphorbol 13-acetate. Level of TIMP-2 (zeige TIMP2 Proteine) mRNA was not affected by any treatments.

  4. the different temporal expression patterns of TIMP-1 and TIMP-2 (zeige TIMP2 Proteine) suggest that TIMP-1 may be important for luteal formation and development, while TIMP-2 (zeige TIMP2 Proteine) may play significant roles during luteal development and maintenance

  5. analysis of species specificity of human and bovine TIMP-1 binding to mouse TIMP-1 receptor

Human Metalloproteinase Inhibitor 1 (TIMP1) Interaktionspartner

  1. Results suggest a crucial role of MMP9 (zeige MMP9 Proteine) at the early stage of carcinogenesis in the large intestine. The increase in MMP9 (zeige MMP9 Proteine) and TIMP1 mRNA concentration and the decrease in MMP28 (zeige MMP28 Proteine) in the large intestinal tissue may be a confirmation of cancer.

  2. Expression of TIMP1 is i (zeige CD63 Proteine)ncreased in chronic pancreatitis, pancreatic intra-epithelial neoplasia, and pancreatic ductal adenocarcinoma tissues from patients. TIMP1 signaling via CD63 leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells.

  3. Our study provides information on the dynamic changes of MMP-9 (zeige MMP9 Proteine)-TIMP-1 system and S100B (zeige S100B Proteine) in the perioperative period. Preoperative reduction of TIMP-1 might be predictive for shunt requirement but future studies are required for verification.

  4. Serum TIMP1 did not differ significantly between normal weight, overweight, and obese participants.

  5. this study shows that increased TIMP-1 expression could promote the migration of hepatocellular carcinoma cells

  6. Tuberculosis patients have increased serum levels of TIMP-1 compared with healthy controls and pneumonia patients.

  7. The tumor/stroma TIMP-1 intensity ratio in tissue is useful to predict tumor recurrence in non-small cell lung cancer.

  8. Expression of TIMP-1 was significantly reduced in unstable carotid plaques compared with stable ones.

  9. TIMP-1 and-2 are primarily markers of an early function of the transplanted kidney.

  10. Increased expression ratio of MMP9 (zeige MMP9 Proteine)/TIMP-1 was observed in relapsing-remitting multiple sclerosis patients that responded to IFN-beta (zeige IFNB1 Proteine) therapy.

Pig (Porcine) Metalloproteinase Inhibitor 1 (TIMP1) Interaktionspartner

  1. we demonstrated the presence of high molecular weight (HMW) complexes (130, 170, and 220 kDa) containing MMP9 (zeige MMP9 Proteine), TIMP1, and NGAL (zeige LCN2 Proteine) (also MMP2 (zeige MMP2 Proteine) in 220 kDa complex) without proteolytic activity.

  2. Hemodialysis graft placement leads to early increases in wall shear stress, VEGF-A (zeige VEGFA Proteine), pro-MMP-9 (zeige MMP9 Proteine), MMP-2 (zeige MMP2 Proteine), VEGFR-1 (zeige FLT1 Proteine), VEGFR-2 (zeige KDR Proteine), and TIMP-1, which may contribute to the development of venous stenosis.

  3. Results indicate that leukemia inhibitory factor (LIF (zeige LIF Proteine)) and Oncostatin M (zeige OSM Proteine) increase the expression of MMP-1 (zeige MMP1 Proteine), MMP-3 (zeige MMP3 Proteine), and TIMP-1 several fold, and that their expression is reduced to basal levels in the presence of the LIF (zeige LIF Proteine) antagonist MH35-BD.

Mouse (Murine) Metalloproteinase Inhibitor 1 (TIMP1) Interaktionspartner

  1. TIMP1 signaling via CD63 (zeige CD63 Proteine) leads to activation of hepatic stellate cells, which create an environment in the liver that increases its susceptibility to pancreatic tumor cells.

  2. This study highlights a previously undescribed integral role for TIMP1 in both vascular network maturation and adaptations to ischemia or alterations in flow.

  3. TIMP-1 was identified as a selectively upregulated component secreted from immature astrocytes from human pluripotent stem cells.

  4. demonstrate that TIMP-2 (zeige TIMP2 Proteine) plays a greater protective role than TIMP-1 during the pathogenesis of atherosclerosis

  5. Our findings reveal that elevated levels of TIMP-1 impact on neutrophil homeostasis via signaling through CD63 (zeige CD63 Proteine).

  6. TIMP-1 is a ligand of LRP-1 (zeige LRP1 Proteine) and we highlight a new example of its MMP-independent, cytokine-like functions.

  7. RAB37 (zeige RAB37 Proteine) regulates the exocytosis of TIMP1 in a nucleotide-dependent manner to inactivate MMP9 (zeige MMP9 Proteine) migration axis in vitro and in vivo and to suppress tumor metastasis.

  8. PDGF-D (zeige PDGFD Proteine) intensifies fibrogenesis by interfering with the fibrolytic activity of the TIMP-1/MMP-2 (zeige MMP2 Proteine)/MMP (zeige MMP2 Proteine)-9 (zeige MMP9 Proteine) system, and PDGF-D (zeige PDGFD Proteine) signaling is mediated through both PDGF (zeige PDGFA Proteine)-alpha and -beta receptors.

  9. Reduced beta(2)GP I plays a role in diabetic mice related to vascular protection, inhibiting vascular lipid deposition, and plaque formation by reducing MMPs/TIMPs expression through down-regulation of the p38MAPK (zeige MAPK14 Proteine) signaling pathway.

  10. Expansion of stem cells counteracts age-related mammary regression in compound Timp1/Timp3 (zeige TIMP3 Proteine)-deficient mice.

Rabbit Metalloproteinase Inhibitor 1 (TIMP1) Interaktionspartner

  1. Hemoperfusion could obviously reduce oxidative stress and the expression levels of MMP-2 (zeige MMP2 Proteine), MMP-9 (zeige MMP9 Proteine) and TIMP-1 in rabbits with acute paraquat poisoning.

TIMP1 Protein Überblick

Protein Überblick

This gene belongs to the TIMP gene family. The proteins encoded by this gene family are natural inhibitors of the matrix metalloproteinases (MMPs), a group of peptidases involved in degradation of the extracellular matrix. In addition to its inhibitory role against most of the known MMPs, the encoded protein is able to promote cell proliferation in a wide range of cell types, and may also have an anti-apoptotic function. Transcription of this gene is highly inducible in response to many cytokines and hormones. In addition, the expression from some but not all inactive X chromosomes suggests that this gene inactivation is polymorphic in human females. This gene is located within intron 6 of the synapsin I gene and is transcribed in the opposite direction.

Genbezeichner und Symbole assoziert mit TIMP1

  • TIMP metallopeptidase inhibitor 1 (TIMP1)
  • TIMP metallopeptidase inhibitor 1 (Timp1)
  • tissue inhibitor of metalloproteinase 1 (Timp1)
  • tissue inhibitor of metalloproteinase 1 (LOC100009047)
  • Clgi Protein
  • EPA Protein
  • EPO Protein
  • HCI Protein
  • Timp Protein
  • TIMP-1 Protein
  • TIMP1 Protein

Bezeichner auf Proteinebene für TIMP1

EG-1 , TIMP-1 , embryogenin-1 , metalloproteinase inhibitor 1 , tissue inhibitor of metalloproteinase 1 (erythroid potentiating activity, collagenase inhibitor) , tissue inhibitor of metalloproteinases 1 , tissue inhibitor of matrix metalloproteinase-1 , tissue inhibitor of metalloproteinase 1 , collagenase inhibitor , erythroid potentiating activity , erythroid-potentiating activity , fibroblast collagenase inhibitor , metalloproteinase tissue inhibitor 1 , tissue inhibitor of metallopeptidase 1 , metalloproteinase tissue inhibitor , EPA , TPA-S1 , TPA-induced protein , collagenase inhibitor 16C8 fibroblast , tissue inhibitor of metalloproteinase-1

GENE ID SPEZIES
282092 Bos taurus
403816 Canis lupus familiaris
7076 Homo sapiens
396862 Sus scrofa
116510 Rattus norvegicus
443331 Ovis aries
21857 Mus musculus
100009047 Oryctolagus cuniculus
100034220 Equus caballus
574348 Macaca mulatta
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