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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Zusätzlich bieten wir Ihnen Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Antikörper (443) und Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase) Kits (162) und viele weitere Produktgruppen zu diesem Protein an.
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endogenously secreted chemerin (zeige RARRES2 Proteine) plays an autocrine/paracrine role in white adipose tissue, identifying chemerin (zeige RARRES2 Proteine) as a therapeutic target to modulate adipose remodelling.
Overexpression of Mmp3 in 3T3-L1 preadipocytes inhibited differentiation. High fat diet-induced obesity downregulates adipocyte MMP3 expression to trigger adipogenesis, and adipocyte TIMP4 (zeige TIMP4 Proteine) may modulate this process to regulate hyperplastic vs. hypertrophic adipose tissue expansion, fat distribution, and metabolic health in a sex- and depot-dependent manner.
Matrix metalloprotease (zeige ADAMTS7 Proteine) 3 (MMP3), an endogenous neuronal activator of microglia, increased cytokine release from YAC128 microglia compared to wildtype microglia. We found elevated MMP levels in Huntington's Disease (HD) CSF (zeige CSF2 Proteine), and MMP levels correlate with disease severity in HD. These data support a novel role for MMPs and microglial activation in HD pathogenesis.
These results indicate that periodic induction, via use of an eye drop, of AAV-mediated secretion of MMP-3 into aqueous humour could have therapeutic potential for those cases of glaucoma that are sub-optimally responsive to conventional pressure-reducing medications.
Data show that loss of loss of matrix metalloproteinase-3 (MMP-3) repressed the upregulation of the chemokines monocyte chemoattractant protein (MCP)-1 (zeige CPT1B Proteine) and (C-X-C motif) ligand 1 (CXCL1 (zeige CXCL1 Proteine)).
Mmp3-knockout mice maintained higher arterial oxygenation compared to wild-type mice in a model of acute lung injury.
NMP4 (zeige ZNF384 Proteine) deficiency suppressed the arthritis-induced increase in bone resorption, expression of RANKL (zeige TNFSF11 Proteine) and MMP-3 mRNA.
MMP-3 produced in blood vessel endothelial cells after spinal cord injury serves as an endogenous molecule for microglial activation followed by p38MAPK (zeige MAPK14 Proteine) activation and proNGF production
genetic inactivation of MMP-3 has profound effects on the structural integrity and plasticity response of the visual cortex of adult mice
study found significant increases of MMP-3 and MMP-12 (zeige MMP12 Proteine) mRNA levels and MMP12 (zeige MMP12 Proteine) zymographic activities in response to Cryptococcus neoformans infection but not C. gattii infection
results suggest that MMP1 (zeige MMP1 Proteine)-1607 1G/2G, MMP3-1171 5A/6A and MMP9 (zeige MMP9 Proteine)-1562 C/T gene polymorphisms have synergistic effect on breast cancer. The interactions of MMPs clinical risk factors such as lymph node involvement has shown a strong correlation and might influence the 5-years survival rate, suggesting their potential role in the breast carcinogenesis
mRNA levels of HSP family members (HSP70B', HSP72 (zeige HSPA1A Proteine), HSP40/DNAJ (zeige DNAJB1 Proteine), and HSP20 (zeige HSPB6 Proteine)/CRYAB (zeige CRYAB Proteine)) are upregulated by the intracellular MMP3 overload.
IL-21 (zeige IL17C Proteine) levels in rheumatoid arthritis synovial fluid were associated with matrix metalloproteinase (MMP)-1 (zeige MMP1 Proteine) and MMP-3.
The genetic polymorphism of MMP-1 and MMP-3 is associated with rotator cuff tear. Individuals with haplotype 2G/5A were more susceptible to rotator cuff tears in the population studied.
Taken together with our previous findings, we have replicated our results from the rodent system in a novel human system. We have revealed a unique sequential cascade involving Atg10 (zeige ATG10 Proteine), Wnt5a (zeige WNT5A Proteine), alpha1 integrin (zeige ITGA1 Proteine), and matrix metalloproteinase-3 in GS/BMP-4 (zeige BMP4 Proteine)-induced differentiation of hiPS cells into odontoblast-like cells at a relatively early stage.
These observations suggest a crucial role for cancer-associated fibroblasts and fibroblast growth factor-1 (zeige FGF1 Proteine)/fibroblast growth factor receptor 4 (zeige FGFR4 Proteine) signaling in the progression of ovarian cancer. the expression level of Snail1 (zeige SNAI1 Proteine) and MMP3 was reduced, while the expression level of E-cadherin (zeige CDH1 Proteine) increased
MMP3 overexpression is associated with Melanoma Tumor Growth and Metastasis.
Matrix metalloprotease (MMP) regulation was the top pathway involved in gingival aging. MMP3, MMP9 (zeige MMP9 Proteine), MMP12 (zeige MMP12 Proteine), and MMP13 (zeige MMP13 Proteine) were upregulated in old gingival tissues, concomitantly with interleukin-1 beta (IL1B (zeige IL1B Proteine)) expression.
Three previously investigated MMP3 variants (rs679620, rs591058 and rs650108) in addition to the functional promoter variant (rs3025058) were genotyped in 195 Australian control participants and 79 Australian individuals with chronic Achilles tendinopathy.
MMP-3 expression is deregulated in osteosarcomas and this potentially contributes to metastasis and might be a promising marker for the prognosis and therapy of metastatic osteosarcoma.
The present study was aimed to determine the association between metalloproteinase 3 (MMP3), transforming growth factor beta 1 (TGFbeta1 (zeige TGFB1 Proteine)) and collagen type X alpha I (COL10A1 (zeige COL10A1 Proteine)) gene polymorphisms with traits related to leg weakness in pigs.
the identification of MMP1 (zeige MMP1 Proteine) and MMP10 (zeige MMP10 Proteine) genes in swine is reported.
contribution of MMPs to the inflammatory breakdown of the blood-CSF (zeige CSF2 Proteine) barrier in vitro
Results indicate that leukemia inhibitory factor (LIF (zeige LIF Proteine)) and Oncostatin M (zeige OSM Proteine) increase the expression of MMP-1 (zeige MMP1 Proteine), MMP-3, and TIMP-1 (zeige TIMP1 Proteine) several fold, and that their expression is reduced to basal levels in the presence of the LIF (zeige LIF Proteine) antagonist MH35-BD.
Compromised autophagy may be related to the osteoarthritis progression; JNK (zeige MAPK8 Proteine) and p38 (zeige MAPK14 Proteine) MAPKs up-regulate MMP3 and down-regulate autophagy.
chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.
Ulinastatin (zeige AMBP Proteine) effectively inhibited the increased expression of MMP-2 (zeige MMP2 Proteine), MMP-3, and iNOS (zeige NOS2 Proteine) in degenerated NP cells induced by IL-1beta (zeige IL1B Proteine) in vitro.
Tongxinluo can inhibit the expression of MMP-3 and 9 and increase the expression of PPARgamma (zeige PPARG Proteine) in atherosclerotic rabbits.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
, matrix metalloproteinase 3
, matrix metalloproteinase-3
, stromelysin 1
, PTR1 protein
, matrix metalloproteinase 3 (stromelysin 1, progelatinase)
, metalloproteinase 3 receptor
, matrix metallopeptidase 3 (stromelysin 1, progelatinase)
, matrix metalloproteinase 10 (stromelysin 2)