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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as art. Zusätzlich bieten wir Ihnen Matrix Metallopeptidase 13 (Collagenase 3) Kits (123) und Matrix Metallopeptidase 13 (Collagenase 3) Proteine (49) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 287 products:
Human Polyclonal MMP13 Primary Antibody für EIA, IHC (p) - ABIN358686
Roy-Beaudry, Martel-Pelletier, Pelletier, MBarek, Christgau, Shipkolye, Moldovan: Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction. in Arthritis and rheumatism 2003
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Human Polyclonal MMP13 Primary Antibody für IF (p), IHC (p) - ABIN670341
Luo, Zhang, Wang, Hu, Song, Su, Zhang: Alendronate retards the progression of lumbar intervertebral disc degeneration in ovariectomized rats. in Bone 2013
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Cow (Bovine) Polyclonal MMP13 Primary Antibody für IP, IHC - ABIN223238
Spinale, Escobar, Mukherjee, Zavadzkas, Saunders, Jeffords, Leone, Beck, Bouges, Stroud: Cardiac-restricted overexpression of membrane type-1 matrix metalloproteinase in mice: effects on myocardial remodeling with aging. in Circulation. Heart failure 2009
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Human Monoclonal MMP13 Primary Antibody für IHC (p), IP - ABIN180404
Pei, Yi: A high-level mammalian expression system based on the Madin-Darby canine kidney cell line. in Protein expression and purification 1998
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Cow (Bovine) Polyclonal MMP13 Primary Antibody für WB - ABIN2786656
Borghese, Chiche, Vernerey, Chenot, Mir, Bijaoui, Bonaiti-Pellié, Chapron: Genetic polymorphisms of matrix metalloproteinase 12 and 13 genes are implicated in endometriosis progression. in Human reproduction (Oxford, England) 2008
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Human Monoclonal MMP13 Primary Antibody für IF, IHC - ABIN4334944
Huang, Ao, Li, Wu, Xu, Deng, Chen, Yin, Cheng: Autophagy Protects Advanced Glycation End Product-Induced Apoptosis and Expression of MMP-3 and MMP-13 in Rat Chondrocytes. in BioMed research international 2017
Cow (Bovine) Polyclonal MMP13 Primary Antibody für ICC, IF - ABIN4334942
Ma, Liu, Wang, Chen, Liu, Li, Xiang, Wei, Duan, Han: Tamoxifen induces the development of hernia in mice by activating MMP-2 and MMP-13 expression. in Biochimica et biophysica acta 2015
Human Polyclonal MMP13 Primary Antibody für IHC (p), WB - ABIN390137
Im, Pacione, Chubinskaya, Van Wijnen, Sun, Loeser: Inhibitory effects of insulin-like growth factor-1 and osteogenic protein-1 on fibronectin fragment- and interleukin-1beta-stimulated matrix metalloproteinase-13 expression in human chondrocytes. in The Journal of biological chemistry 2003
MeHg impairs tail development at least partially by activation of the tissue remodeling proteases Mmp9 (zeige MMP9 Antikörper) and Mmp13.
Zebra fish embryogenesis requires MMP-13 and dexamethasone and hydrocortisone modulate the expression of this gene, leading to increased activity and potentially contributing to subsequent dysmorphogenesis.
JNK (zeige MAPK8 Antikörper)-Mmp13 signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
XCL3 and XCL4 can be differentially induced by prolactin (zeige PRL Antikörper) and thyroid hormone (zeige PTH Antikörper)(3)
The progressive process of articular cartilage degeneration was significantly delayed in the knee joints of Ddr2 (zeige DDR2 Antikörper)-deficient mice in comparison to their control littermates. Articular cartilage damage in the knee joints of the mice was associated with increased expression profiles of both Ddr2 (zeige DDR2 Antikörper) and matrix metalloproteinase 13.
Postnatal chondrocyte-specific deletion of Hdac3 (zeige HDAC3 Antikörper) with an inducible Col2a1 (zeige COL2A1 Antikörper)-Cre caused premature production of pErk1/2 and Mmp13 in the growth plate.
Mmp13 is selectively regulated of by 1,25-Dihydroxyvitamin D3, PTH (zeige PTH Antikörper), and Osterix (zeige SP7 Antikörper) through distal enhancers.
Our study contributes to the understanding of the role of HIF1alpha (zeige HIF1A Antikörper) in OA and highlights the HIF1alpha (zeige HIF1A Antikörper)-beta-catenin (zeige CTNNB1 Antikörper) interaction, thus providing new insights into the impact of hypoxia in articular cartilage.
Matrix metalloproteinases (MMP) are effectors of hippocampal neuroplasticity in the adult central nervous system and that the MMP-1 (zeige MMP1 Antikörper)/protease-activated receptor-1 (zeige F2R Antikörper) axis may play a role in neurogenesis following physiological and/or pathological stimuli.
IL-1Ra (zeige IL1RN Antikörper) is associated with MMP-13 expression and has a novel function in such regulation without interference of the IL-1 (zeige IL1A Antikörper) signaling cascade.
We reveal a novel role of AP-2epsilon in the regulation of gene expression in articular chondrocytes, as well as in osteoarthritis development, through modulation of Mmp13 expression and activity.
B-16 melanoma cells with up-regulated MMP-13 expression promoted invasion of tumor cells through Matrigel compared with control cells transfected with empty vector. Knocked-down MMP-13 expression also decreased invading cell numbers.
MMP-12 (zeige MMP12 Antikörper) and MMP-13 alter strain K infection in mice and play a role in inflammatory regulation by modulating cytokine levels.
Data indicate that tamoxifen decreased collage type II COL2A1 (zeige COL2A1 Antikörper) by activating matrix metallopeptidases MMP-2 (zeige MMP2 Antikörper)/13 expression.
High MMP13 expression is associated with intervertebral disc degeneration.
data demonstrate that MMP-13 is critical for the development of osteolytic lesions in Multiple myeloma and that targeting the MMP-13 protein - rather than its catalytic activity - constitutes a potential approach to mitigating bone disease in affected patients.
Endoplasmic reticulum stress participates in the progress of senescence and apoptosis of osteoarthritic chondrocytes, which manifested in increased expression of ADAMTS5 (zeige ADAMTS5 Antikörper), MMP13, and decreased COL2A1 (zeige COL2A1 Antikörper) expression.
Matrix metalloprotease (zeige ADAM8 Antikörper) (MMP) regulation was the top pathway involved in gingival aging. MMP3 (zeige MMP3 Antikörper), MMP9 (zeige MMP9 Antikörper), MMP12 (zeige MMP12 Antikörper), and MMP13 were upregulated in old gingival tissues, concomitantly with interleukin-1 beta (IL1B (zeige IL1B Antikörper)) expression.
these findings support roles for both cFOS (indirect) and ATF3 (zeige ATF3 Antikörper) (direct) in effecting MMP13 transcription in human chondrocytes.
Oxytocin prevents cartilage matrix destruction via regulating MMP1 (zeige MMP1 Antikörper) and MMP13.
These studies have uncovered a new, ATP6V1H (zeige ATP6V1H Antikörper)-mediated pathway that regulates bone formation, and defines a new mechanism of disease that leads to bone loss. We propose that MMP9 (zeige MMP9 Antikörper)/MMP13 could be therapeutic targets for patients with this rare genetic disease.
To conclude, Pseudomonas aeruginosa infection induced the expression of matrix metalloproteinases, and Pseudomonas aeruginosa type III secretion system appeared to be a key player in MMP-12 (zeige MMP12 Antikörper) and MMP-13 expression, which is further controlled by NF-kappaB (zeige NFKB1 Antikörper) signaling.
In osteoarthritis (OA) chondrocytes, hydrostatic pressure (HP) restores the expression levels of some miRNAs, downregulates MMP-13, ADAMTS-5 (zeige ADAMTS5 Antikörper), and HDAC-4 (zeige HDAC4 Antikörper), and modulates the Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) pathway activation.
These results suggested that HIF-2alpha (zeige EPAS1 Antikörper) may cause meniscal matrix degradation by transactivation of MMP-13
The DNA microarray analysis for matrix metalloproteinase (zeige MMP20 PLURAL_@17598@) (MMP)-related mRNA expression in equine superficial digital flexor tendinitis indicated that mRNA level of MMP-13 was apparently up-regulated in the tendinitis as compared to normal tendon.
p38 (zeige MAPK14 Antikörper) phosphorylation and MMP13 expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
These data identify atypical PKC isozymes as STAT and ERK activators that mediate c-fos and collagenase expression.
MMP-13 treatment of fresh articular cartilage results in cleaved fibromodulin (zeige FMOD Antikörper) fragments
increased in bovine preovulatory follicles following the gonadotropin surge but no up-regulation of MMP-1 (zeige MMP1 Antikörper) and MMP-13 (follicular apex (zeige APEX1 Antikörper) vs. base) for the preovulatory collagenolysis required for follicle rupture
involvement of p38 MAP kinase (zeige MAPK14 Antikörper) in the hyaluronan oligosaccharide induction of MMP-13
MMP-13 and collagenase have roles in chondrocyte hypertrophy induced by type II collagen (zeige COL2A1 Antikörper)
At high but naturally occurring concentrations the collagen peptide CB12 (zeige PABPC4 Antikörper)-II induced an increase in the expressions of MMP-13 and cleavage of type II collagen (zeige COL2A1 Antikörper) by collagenase in the mid zone and also in the superficial zone.
These results suggest that PEP-1-SIRT2 (zeige SIRT2 Antikörper) promotes matrix metalloproteinases-induced dedifferentiation via ERK (zeige MAPK1 Antikörper) signaling in articular chondrocytes.
chitosan-pDNA nanoparticles encoding shRNA targeting MMP-3 (zeige MMP3 Antikörper) and -13 had great potential in silencing the dedifferentiation-related genes for regenerating prolonged and endurable cartilage.
Leptin (zeige LEP Antikörper) can induce MMP-13 and have a synergistic induction effect on NO with TNF-alpha (zeige TNF Antikörper) in rabbit articular chondrocytes in vitro.
TNF-alpha (zeige TNF Antikörper) induced MMP-13 expression by condylar cells might be involved in the degradation of the juvenile condyle.
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
matrix metalloproteinase 13
, matrix metallopeptidase 13 (collagenase 3)
, collagenase 3
, gene A
, gene 11
, collagenase 3-like
, interstitial collagenase
, matrix metalloproteinase-13
, matrix metalloproteinase 13 (collagenase 3)