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The protein encoded by MGP is secreted and likely acts as an inhibitor of bone formation. Zusätzlich bieten wir Ihnen Matrix Gla Protein Antikörper (63) und Matrix Gla Protein Proteine (28) und viele weitere Produktgruppen zu diesem Protein an.
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Human MGP ELISA Kit für Sandwich ELISA - ABIN367214
Najafi, Roustazadeh, Amirfarhangi, Kazemi: Matrix Gla protein (MGP) promoter polymorphic variants and its serum level in stenosis of coronary artery. in Molecular biology reports 2014
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Mouse (Murine) MGP ELISA Kit für Sandwich ELISA - ABIN857742
Wang, Chen, Zhang, Yu, Zhang, Gong, Shao, Lu, Gao, Chen, Chen, Hui: Common genetic variants of MGP are associated with calcification on the arterial wall but not with calcification present in the atherosclerotic plaques. in Circulation. Cardiovascular genetics 2013
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Usefulnees of nonmammalian model systems to elucidate the complex regulation of MGP gene transcription.
These data also indicate that MGP is under dual regulation by runx2 (zeige RUNX2 ELISA Kits) through the use of various isoforms and context-dependent formation of transcriptional complexes.
MGP is a multi-functional inhibitor of normal and abnormal angiogenesis that may function by coordinating with both Notch and BMP signaling pathways
In contrast with results obtained for previously studied marine fishes, in zebrafish and Senegal sole Mgp accumulates in both calcified tissues and non-mieralized vessel walls of the vascular system.
MGP is significantly repressed by miR (zeige MLXIP ELISA Kits)-155 in breast cancer MCF-7 cells, and concomitantly there is a stimulation of cell proliferation and cell invasiveness.
ectopic expression of Mgp in murine and human osteosarcoma cells led to a marked increase in lung metastasis. Abrogation of Mgp prevented lung metastatic activity, an effect that was rescued by forced expression. Mgp levels dramatically altered endothelial adhesion, trans-endothelial migration in vitro and tumour cell extravasation ability in vivo
MGP rs4236 [A/G] gene polymorphism was not to be associated with subgingival dental calculus. Also, that GCF (zeige GUCY2F ELISA Kits) MGP levels were detected higher in patients with subgingival dental calculus than those without subgingival dental calculus independently of polymorphism, may be the effect of adaptive mechanism to inhibit calculus formation.
The substitution of threonine by alanine due to MGP exon 4 Thr83Ala polymorphism is related to a decrease in the likelihood of arterial calcification in female persons in the Ukrainian population
Correlations of plasma desphosphorylated uncarboxylated matrix Gla protein (dp-ucMGP) with vascular calcification and vascular stiffness in chronic kidney disease. Plasma dp-ucMGP was positively associated with vascular calcification and might be utilized as an early marker for vascular calcification in CKD patients.
It is assumed that Lp-PLA2 (zeige Lp-PLA2 ELISA Kits) is involved in vascular calcification and that dp-ucMGP is a more appropriate biomarker of residual risk than Lp-PLA2 (zeige Lp-PLA2 ELISA Kits) itself.
Data shoed increased GAS6 (zeige GAS6 ELISA Kits) and decreased MGP levels in hemodialysis patients, as mediators of induction or prevention of vascular calcification.
Altering NOTCH1 (zeige NOTCH1 ELISA Kits) levels affected MGP mRNA and protein.
Uncarboxylated MGP in synovial fluid might serve as a novel biomarker for assessing knee osteoarthritis progression.
MGP expression is significantly lower in diseased relative to normal aortic valve interstitial cells. Lack of this important "anti-calcification" protein may contribute to calcification of the aortic valve.
loss of MGP causes dysregulation of early endothelial differentiation.
Matrix Gla protein limits pulmonary arteriovenous malformations in ALK1 (zeige ACVRL1 ELISA Kits) deficiency.
expression of MGP and OCN increased gradually in the murine developing tibial epiphysis, and the two mineral-associated proteins may occur at the same location during a particular period, but at different levels.
Elastin (zeige ELN ELISA Kits) haploinsufficiency impedes the progression of arterial calcification in MGP-deficient mice.
The arterial calcification, not MGP deficiency itself, causes the low bone mass phenotype in Mgp-/- mice.
Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 (zeige TGM2 ELISA Kits) and elastin (zeige ELN ELISA Kits) fragmentation associated with induction of adipsin (zeige CFD ELISA Kits).
Mgp gene deletion may have a role in arteriovenous malformations
MGP is a known inhibitor of mineralization, and mice deficient in Mgp show severe vascular calcification and premature bone mineralization.
Inorganic phosphate(Pi) regulates MGP expression in growth plate chondrocytes, thereby suggesting a key role for Pi and ERK1/2 (zeige MAPK1/3 ELISA Kits) in the regulation of bone formation.
High DNA methylation (zeige HELLS ELISA Kits) resulting in the down regulation of matrix Gla protein is associated with osteochondrosis.
Selective CaSR (zeige CASR ELISA Kits) activation, either by extracellular calcium or AMG (zeige AMELX ELISA Kits) 641, increased MGP expression in vivo in the arterial wall and in vitro in bovine vascular smooth muscle cells.
the effect of MGP on calcification and osteogenic differentiation is determined by availability of BMP-2 (zeige BMP2 ELISA Kits)
MGP plays a role in endothelial cell function, by increasing transforming growth factor-beta1 activity and stimulating VEGF expression
MGP has a novel binding activity for vitronectin (zeige VTN ELISA Kits)
Heat shock protein 70 (zeige HSP70 ELISA Kits) enhances vascular bone morphogenetic protein-4 (zeige BMP4 ELISA Kits) signaling by binding matrix Gla protein.
The protein encoded by this gene is secreted and likely acts as an inhibitor of bone formation. The encoded protein is found in the organic matrix of bone and cartilage. Defects in this gene are a cause of Keutel syndrome (KS). Two transcript variants encoding different isoforms have been found for this gene.
matrix Gla protein
, Matrix Gla protein
, cell growth-inhibiting gene 36 protein
, matrix gamma-carboxyglutamate (gla) protein