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MSL3 encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. Zusätzlich bieten wir Ihnen MSL3 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal MSL3 Primary Antibody für IF, WB - ABIN524348
Kapoor-Vazirani, Vertino: A dual role for the histone methyltransferase PR-SET7/SETD8 and histone H4 lysine 20 monomethylation in the local regulation of RNA polymerase II pausing. in The Journal of biological chemistry 2014
MSL3 plays an important role in targeting the male specific lethal complex to chromatin in both humans and flies by binding to H4K20Me(1).
A multisubunit human histone acetylase complex that contains homologs of the Drosophila MSL proteins MOF (zeige KAT8 Antikörper), MSL1 (hampin (zeige MSL1 Antikörper) A), MSL2 (zeige MSL2 Antikörper), and MSL3 was described. This complex is responsible for histone H4 lysine-16 acetylation of all cellular chromosomes.
Data show that complete removal of paternally expressed gene 3 (PEG3 (zeige PEG3 Antikörper)) resulted in up-regulation of male-specific lethal 1 (Msl1 (zeige OPRK1 Antikörper)) and male-specific lethal 3 (Msl3).
Msl1 interacts with Msl3 as an extended chain forming an extensive hydrophobic interface, whereas the Msl1-MOF interface involves electrostatic interactions between the HAT domain and a long helix of Msl1.
Analysis of Mid1 (zeige MID1 Antikörper), Hccs (zeige HCCS Antikörper), Arhgap6 (zeige ARHGAP6 Antikörper), and Msl3l1 in X-linked polydactyly (Xpl) and Patchy-fur (Paf (zeige KIAA0101 Antikörper)) mutant mice
This gene encodes a nuclear protein that is similar to the product of the Drosophila male-specific lethal-3 gene. The Drosophila protein plays a critical role in a dosage-compensation pathway, which equalizes X-linked gene expression in males and females. Thus, the human protein is thought to play a similar function in chromatin remodeling and transcriptional regulation, and it has been found as part of a complex that is responsible for histone H4 lysine-16 acetylation. This gene can undergo X inactivation. Alternative splicing results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 2, 7 and 8.
male-specific lethal 3 homolog (Drosophila)
, male-specific lethal 3-like 1
, Male-specific lethal 3-like 1
, MSL3-like 1
, male-specific lethal 3 homolog
, male-specific lethal-3 protein-like 1
, male-specific lethal-3 homolog 1