anti-MDS1 and EVI1 Complex Locus (MECOM) Antikörper

The protein encoded by MECOM is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. Zusätzlich bieten wir Ihnen MDS1 and EVI1 Complex Locus Proteine (8) und MDS1 and EVI1 Complex Locus Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
MECOM 2122 Q03112 , Q13465
MECOM 14013 Q9Z1L8
MECOM 294924  
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Top anti-MDS1 and EVI1 Complex Locus Antikörper auf antikoerper-online.de

Showing 10 out of 118 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-EVI1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:62500<br><b>Positive Control: </b>Hela cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB Host: Rabbit Target Name: EVI1 Sample Tissue: Human 293T Antibody Dilution: 1.0ug/ml Host: Rabbit Target Name: MECOM Sample Tissue: Human 293T Whole Cell Antibody Dilution: 1ug/ml 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert WB WB Suggested Anti-EVI1 Antibody Titration: 0.2-1 ug/ml ELISA Titer: 1:1562500 Positive Control: Human brain 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
358,51 €
Details
Human Kaninchen Unkonjugiert WB <b>WB Suggested Anti-MDS1 Antibody Titration: </b>1.25ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>Raji cell lysate WB Suggested Anti-MDS1 <br /> Antibody Titration: 1.25 µg/mL ELISA Titer: 1:312500 <br /> Positive Control: Raji cell lysate 100 μL Anmelden zum Anzeigen 6 bis 8 Tage
288,68 €
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of EVI1 Antibody (N-term) in CEM cell line lysates (35ug/lane). This demonstrates the EVI1 antibody detected the EVI1 protein (arrow). 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert EIA, WB Western blot analysis of MDS1 Antibody (Center) in mouse NIH-3T3 cell line lysates (35ug/lane). This demonstrates the MDS1 antibody detected the MDS1 protein (arrow). 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Ziege Unkonjugiert ELISA, WB Western Blot: EVI1 Antibody [NBP1-68842] - Analysis of EVI1 in A549 lysate (35ug protein in RIPA buffer) using NBP1-68842 at 2ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 2 bis 4 Tage
311,00 €
Details
Human Maus Unkonjugiert EIA, WB 0.4 mL Anmelden zum Anzeigen 7 bis 9 Tage
407,00 €
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB 100 μL Anmelden zum Anzeigen 13 Days
154,33 €
Details
Human Maus Unkonjugiert WB Western analysis of extracts from 293 cells using PRDM3 antibody. 400 μL Anmelden zum Anzeigen 14 bis 16 Tage
335,24 €
Details

MECOM Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine)
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Rat (Rattus)


Am meisten referenzierte anti-MDS1 and EVI1 Complex Locus Antikörper

  1. Human Polyclonal MECOM Primary Antibody für ELISA, WB - ABIN4270672 : Konrad, Karger, Hackl, Schwarzinger, Herbacek, Wieser: Inducible expression of EVI1 in human myeloid cells causes phenotypes consistent with its role in myelodysplastic syndromes. in Journal of leukocyte biology 2009 (PubMed)

Weitere Antikörper gegen MDS1 and EVI1 Complex Locus Interaktionspartner

Zebrafish MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. nephrogenesis in zebrafish is regulated by interactions between retinoic acid, mecom, and Notch (zeige NOTCH1 Antikörper) signaling

  2. Prdm3 and prdm16 (zeige PRDM16 Antikörper) are strongly expressed in the pharyngeal arches during cranioskeletal development, and their knockdown leads to defects in both the viscerocranium and the neurocranium.

Human MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. discussion of the role of RUNX1 (zeige RUNX1 Antikörper) in diseases caused by their mutations or deletions (review)

  2. Placental hematopoietic stem and progenitor cells likely arise from hematopoietic niches comprised RUNX1 (zeige RUNX1 Antikörper)+ mesenchyme and vascular endothelium. Pregnancy complications that result in preterm birth differentially affect placental hematopoietic stem and progenitor cells localization and RUNX1 (zeige RUNX1 Antikörper) expression

  3. deficiency alters the expression of a crucial subset of TAL1 (zeige TAL1 Antikörper)- and NOTCH1 (zeige NOTCH1 Antikörper)-regulated genes, including the MYB (zeige MYB Antikörper) and MYC (zeige MYC Antikörper) oncogenes, respectively.

  4. Findings represent the first global genome-wide study of EVI1 DNA binding associated with whole transcriptome expression analysis. Results reveal several important genes with an ETS (zeige ETS1 Antikörper)-like binding motif, is involved in terminal myeloid differentiation, cell cycle regulation and apoptosis

  5. Our findings strengthen previous data concerning RUNX1 (zeige RUNX1 Antikörper) mutations in acute myeloid leukemia (zeige BCL11A Antikörper) and support the notion that RUNX1 (zeige RUNX1 Antikörper) mutational status should be integrated into a diagnostic workup of acute myeloid leukemia (zeige BCL11A Antikörper).

  6. Heterozygous germ line mutations in the RUNX1 (zeige RUNX1 Antikörper) gene are responsible genetic events for FPD/AML (zeige RUNX1 Antikörper).

  7. Data suggest that RUNX1 (zeige RUNX1 Antikörper) pays dual roles in normal female sexual development/maturation and tumorigenesis in female-related cancers; "alterations" in RUNX1 (zeige RUNX1 Antikörper), either mutations in RUNX1 (zeige RUNX1 Antikörper) gene or variations in expression of RUNX1 (zeige RUNX1 Antikörper), appear to be associated with breast, ovarian, uterine, and cervical neoplasms. [REVIEW]

  8. The E3 ubiquitin ligase (zeige MUL1 Antikörper) STUB1 (zeige STUB1 Antikörper) is a negative regulator of both RUNX1 (zeige RUNX1 Antikörper) and RUNX1 (zeige RUNX1 Antikörper)-RUNX1T1 (zeige RUNX1T1 Antikörper). Activation of STUB1 (zeige STUB1 Antikörper) could be a promising therapeutic strategy for RUNX1 (zeige RUNX1 Antikörper)-RUNX1T1 (zeige RUNX1T1 Antikörper) leukemia.

  9. The clinical significance of ETV6 (zeige ETV6 Antikörper)-RUNX1 (zeige RUNX1 Antikörper).

  10. Deliver the necessary promotional drive for the progression of ETV6 (zeige ETV6 Antikörper)-RUNX1 (zeige RUNX1 Antikörper)+ pre-leukaemic cells.

Mouse (Murine) MDS1 and EVI1 Complex Locus (MECOM) Interaktionspartner

  1. Gata2 (zeige GATA2 Antikörper) heterozygous deletion confers selective advantage to EVI1-expressing leukemia cell expansion in recipient mice

  2. EVI1 acts as a regulator of its own expression, highlighting the complex regulation of EVI1, and open new directions to better understand the mechanisms of EVI1 overexpressing leukemias.

  3. the DNA sequences to which EVI1 binds at +35 and +37 kb and show that mutation of one of these releases Cebpa (zeige CEBPA Antikörper) from EVI1-induced suppression.

  4. Evi1(+)DA-3 cells modified to express an intracellular form of GM-CSF (zeige CSF2 Antikörper), acquired growth factor independence and transplantability and caused an overt leukemia in syngeneic hosts, without increasing serum GM-CSF (zeige CSF2 Antikörper) levels.

  5. Survivin (zeige BIRC5 Antikörper) partially regulates HSC (zeige FUT1 Antikörper) function by modulating the Evi-1 transcription factor and its downstream targets

  6. Thrombopoietin (zeige THPO Antikörper)/MPL (zeige MPL Antikörper) signaling confers growth and survival capacity to CD41-positive cells in a mouse model of Evi1 leukemia.

  7. Prdm16 (zeige PRDM16 Antikörper) and Prdm3 control postnatal BAT (zeige BAAT Antikörper) identity and function.

  8. Mice carrying a hypomorphic Evi1 allele are embryonic viable but exhibit severe congenital heart defects.

  9. PR-domain protein ME has an essential role in mixed-lineage leukemia (MLL (zeige MLL Antikörper)) fusion protein (MFP) leukemia

  10. Cotransduction of Evi1 and the shortest isoform of C/EBPbeta (zeige CEBPB Antikörper), liver inhibitory protein (LIP), induced acute myeloid leukemia (zeige BCL11A Antikörper) with short latencies in a mouse bone marow transplantation model.

MDS1 and EVI1 Complex Locus (MECOM) Antigen-Profil

Protein Überblick

Core binding factor (CBF) is a heterodimeric transcription factor that binds to the core element of many enhancers and promoters. The protein encoded by this gene represents the alpha subunit of CBF and is thought to be involved in the development of normal hematopoiesis. Chromosomal translocations involving this gene are well-documented and have been associated with several types of leukemia. Three transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit MECOM

  • MDS1 and EVI1 complex locus (mecom) Antikörper
  • MDS1 and EVI1 complex locus (MECOM) Antikörper
  • MDS1 and EVI1 complex locus (LOC100343228) Antikörper
  • MDS1 and EVI1 complex locus (Mecom) Antikörper
  • runt-related transcription factor 1 (RUNX1) Antikörper
  • AML1 Antikörper
  • AML1-EVI-1 Antikörper
  • AMLCR1 Antikörper
  • CBFA2 Antikörper
  • D630039M04Rik Antikörper
  • EVI-1 Antikörper
  • Evi1 Antikörper
  • im:7140716 Antikörper
  • Jbo Antikörper
  • Mds Antikörper
  • Mds1 Antikörper
  • Mds1-Evi1 Antikörper
  • PEBP2aB Antikörper
  • Prdm3 Antikörper
  • Znfpr1b1 Antikörper

Bezeichner auf Proteinebene für MECOM

ecotropic viral integration site 1 , PR domain containing 3 , MDS1 and EVI1 complex locus , MDS1 and EVI1 complex locus protein EVI1-like , AML1-EVI-1 fusion protein , MDS1 and EVI1 complex locus protein EVI1 , MDS1 and EVI1 complex locus protein MDS1 , ecotropic virus integration site 1 protein homolog , myelodysplasia syndrome-associated protein 1 , oncogene EVI1 , zinc finger protein Evi1 , ecotropic virus integration site 1 protein , myelodysplasia syndrome 1 homolog , myelodysplasia syndrome 1 protein homolog , CBF-alpha-2 , PEA2-alpha B , PEBP2-alpha B , SL3-3 enhancer factor 1 alpha B subunit , SL3/AKV core-binding factor alpha B subunit , acute myeloid leukemia 1 protein , core-binding factor, runt domain, alpha subunit 2 , oncogene AML-1 , polyomavirus enhancer-binding protein 2 alpha B subunit

GENE ID SPEZIES
497407 Danio rerio
460837 Pan troglodytes
698603 Macaca mulatta
100343228 Oryctolagus cuniculus
100403987 Callithrix jacchus
100591579 Nomascus leucogenys
2122 Homo sapiens
14013 Mus musculus
424997 Gallus gallus
488148 Canis lupus familiaris
532209 Bos taurus
294924 Rattus norvegicus
861 Homo sapiens
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