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Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. Zusätzlich bieten wir Ihnen LCP1 Kits (10) und LCP1 Proteine (6) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 91 products:
Cytomegalovirus (CMV) Polyclonal LCP1 Primary Antibody für BP, ELISA - ABIN1586192
Flinsenberg, Compeer, Koning, Klein, Amelung, van Baarle, Boelens, Boes: Fc? receptor antigen targeting potentiates cross-presentation by human blood and lymphoid tissue BDCA-3+ dendritic cells. in Blood 2012
Show all 2 Pubmed References
Human Polyclonal LCP1 Primary Antibody für ICC, IF - ABIN4346103
Bachmann, Burté, Pramana, Conte, Brown, Orimadegun, Ajetunmobi, Afolabi, Akinkunmi, Omokhodion, Akinbami, Shokunbi, Kampf, Pawitan, Uhlén, Sodeinde, Schwenk, Wahlgren, Fernandez-Reyes, Nilsson: Affinity proteomics reveals elevated muscle proteins in plasma of children with cerebral malaria. in PLoS pathogens 2014
the actin-bundling protein L-plastin (LPL) is required for the perinatal development of alveolar macrophages.
Results identify L-plastin as a key effector of Mst1 (zeige MST1 Antikörper) and establish a novel mechanism linking a signaling intermediate to an actin-binding protein (zeige PFN1 Antikörper) critical to T cell migration.
L-plastin modulates both T- and B-cell function during the germinal center reaction and the production of T-cell-dependent antibody responses.
L-plastin may participate in signaling that enables lymphocyte transmigration
LPL-dependent actin bundling facilitates the formation of lamellipodia and normal immunological synapses and thereby enables T cell activation.
Regulation of sealing ring formation by L-plastin and cortactin (zeige CTTN Antikörper) in osteoclasts.
We thus identify L-plastin as a molecule critical for CCR7 (zeige CCR7 Antikörper)-mediated t-cell motility but dispensable for early CCR7 (zeige CCR7 Antikörper) signaling.
AngII-dependent phosphorylation of LCP1 in cultured podocytes was mediated by the kinases ERK (zeige EPHB2 Antikörper), p90 (zeige CANX Antikörper) ribosomal S6 kinase (zeige RPS6KB1 Antikörper), PKA, or PKC (zeige PRRT2 Antikörper). LCP1 phosphorylation increased filopodia formation.
L-plastin regulates the stability of the immune synapse of naive and effector T-cells. (Review)
The findings support a mechanism in which miR (zeige MLXIP Antikörper)-375 suppresses RUNX1 (zeige RUNX1 Antikörper) levels, resulting in reduced vimentin (zeige VIM Antikörper) and L-plastin expression. Knockdown of RUNX1 (zeige RUNX1 Antikörper), L-plastin, and vimentin (zeige VIM Antikörper) resulted in significant reductions in cell invasion in vitro, indicating the functional significance of miR (zeige MLXIP Antikörper)-375 regulation of specific proteins involved in head and neck squamous cell carcinoma (HNSCC) invasion.
In this study, the authors found that the actin filament bundling abilities of PLS1 (zeige PLS1 Antikörper) and PLS2 were similarly sensitive to Ca(2 (zeige CA2 Antikörper)+) (pCa50 ~6.4), whereas PLS3 (zeige PLS3 Antikörper) was less sensitive (pCa50 ~5.9).
elevated L-plastin expression promotes elongation and reduces protrusion density in cells with relatively lower L-plastin than fascin (zeige FSCN1 Antikörper) levels.
Enhanced nitroxidative stress may results in LPL S-glutathionylation leading to impaired chemotaxis, polarization, and bactericidal activity of human neutrophils.
association of SNPs in LCP1 and CTIF (zeige KIAA0427 Antikörper) with hearing
An NKX3.1 (zeige NKX3-1 Antikörper) binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer
The proteins (HSP90b (zeige HSP90AB1 Antikörper), TSM1 and L-plastin) in the current study may hold potential in differentiating between melanoma and benign nevi in diagnostically challenging cases.
Data suggest that several single-nucleotide polymorphisms (SNPs) of the plastin genes PLS3 (zeige PLS3 Antikörper) and LCP1 could serve as gender- and/or stage-specific molecular predictors of tumor recurrence in stage II/III colorectal cancer as well as therapeutic targets.
Plastins are a family of actin-binding proteins that are conserved throughout eukaryote evolution and expressed in most tissues of higher eukaryotes. In humans, two ubiquitous plastin isoforms (L and T) have been identified. Plastin 1 (otherwise known as Fimbrin) is a third distinct plastin isoform which is specifically expressed at high levels in the small intestine. The L isoform is expressed only in hemopoietic cell lineages, while the T isoform has been found in all other normal cells of solid tissues that have replicative potential (fibroblasts, endothelial cells, epithelial cells, melanocytes, etc.). However, L-plastin has been found in many types of malignant human cells of non-hemopoietic origin suggesting that its expression is induced accompanying tumorigenesis in solid tissues.
, leucocyte-specific plastin 1
, 65 kDa macrophage protein
, L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (65 kDa macrophage protein) (PP65)
, plastin 2, L
, L-plastin (Lymphocyte cytosolic protein 1) (LCP-1) (LC64P)
, Lymphocyte cytosolic protein-1 (plasmin)
, bA139H14.1 (lymphocyte cytosolic protein 1 (L-plastin))
, plastin 2
, epidermal Langerhans cell protein LCP1